Birger Brodin Larsen
Professor
CNS Drug Delivery and Barrier Modelling
Universitetsparken 2
2100 København Ø
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The Pyrazolo[3,4-d]pyrimidine Derivative, SCO-201, Reverses Multidrug Resistance Mediated by ABCG2/BCRP
Ambjørner, S. E. B., Wiese, M., Köhler, S. C., Svindt, J., Lund, X. L., Gajhede, Michael, Saaby, Lasse, Larsen, Birger Brodin, Rump, S., Weigt, H., Brünner, N. & Stenvang, Jan, 4 Mar 2020, In: Cells. 9, 3, 22 p., 613.Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic variants of the human dipeptide transporter PEPT1
Anderle, P., Nielsen, C. U., Pinsonneault, J., Krog, P. L., Larsen, Birger Brodin & Sadée, W., 1 Feb 2006, In: Journal of Pharmacology and Experimental Therapeutics. 316, 2, p. 636-646 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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In vitro evaluation of N-methyl amide tripeptidomimetics as substrates for the human intestinal di-/tri-peptide transporter hPEPT1
Andersen, R., Nielsen, C. U., Begtrup, M., Jørgensen, Flemming Steen, Larsen, Birger Brodin, Frøkjær, Sven & Steffansen, B., 2006, In: European Journal of Pharmaceutical Sciences. 28, 4, p. 325-35 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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In Vitro Membrane Permeation Studies and in Vivo Antinociception of Glycosylated Dmt(1)-DALDA Analogues
Ballet, S., Betti, C., Novoa, A., Tömböly, C., Nielsen, C. U., Helms, H. C., Lesniak, A., Kleczkowska, P., Chung, N. N., Lipkowski, A. W., Larsen, Birger Brodin, Tourwé, D. & Schiller, P. W., 10 Apr 2014, In: ACS Medicinal Chemistry Letters. 5, 4, p. 352-357 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Basolateral glycylsarcosine (Gly-Sar) transport in Caco-2 cell monolayers is pH dependent
Berthelsen, R., Nielsen, C. U. & Larsen, Birger Brodin, Jul 2013, In: Journal of Pharmacy and Pharmacology. 65, 7, p. 970-9 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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IN VITRO MEMBRANE PERMEATION STUDIES AND IN VIVO ANTINOCICEPTION OF GLYCOSYLATED Dmt1-DALDA ANALOGUES
Betti, C., Novoa, A., Tömböly, C., Nielsen, C. U., Helms, H. C. C., Lesniak, A., Klecskowska, P., Chung, N. N., Chung, N. N., Lipkowski, A. W., Larsen, Birger Brodin, Tourwé, D., Schiller, P. W. & Ballet, S., 31 Aug 2014. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Characterization of rPEPT2-mediated Gly-Sar transport parameters in the rat kidney proximal tubule cell line SKPT-0193 cl.2 cultured in basic growth media
Bravo, S. A., Nielsen, C. U., Frøkjær, Sven & Larsen, Birger Brodin, 2005, In: Molecular Pharmaceutics. 2, 2, p. 98-108 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Epidermal growth factor decreases PEPT2 transport capacity and expression in the rat kidney proximal tubule cell line SKPT0193 cl.2
Bravo, S. A., Nielsen, C. U., Amstrup, J., Frøkjær, Sven & Larsen, Birger Brodin, 2004, In: American Journal of Physiology - Renal Physiology. 286, 2, p. 385-393Research output: Contribution to journal › Journal article › Research › peer-review
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In-depth evaluation of Gly-Sar transport parameters as a function of culture time in the Caco-2 cell model
Bravo, S. A., Nielsen, C. U., Amstrup, J., Frøkjær, Sven & Larsen, Birger Brodin, 1 Jan 2004, In: European Journal of Pharmaceutical Sciences. 21, 1, p. 77-86 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Function and expression of the proton-coupled amino acid transporter Slc36a1 along the rat gastrointestinal tract: Implications for intestinal absorption of gaboxadol
Broberg, M. L., Holm, R. K., Tønsberg, H., Frølund, S. B., Ewon, K. B., Nielsen, A. L., Larsen, Birger Brodin, Jensen, A., Kall, M. A., Nielsen, C. U. & Christensen, K. V., 2012, In: British Journal of Pharmacology. 167, 3, p. 654-665Research output: Contribution to journal › Journal article › Research › peer-review
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mRNA expression and transport function of the proton-coupled amino acid transporter, PAT1, along the rat intestine
Broberg, M. L., Larsen, K. B., Holm, R., Larsen, Birger Brodin & Nielsen, C. U., 2010.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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The human proton-coupled amino acid transporter (hPAT1) is a transport system for GABA-like drugs
Broberg, M. L., Frølund, Bente, Larsen, Birger Brodin & Nielsen, C. U., 2007. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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5-Hydroxy-L-tryptohan alters gaboxadol pharmacokinetics in rats: involvement of PAT1 and rOat1 in gaboxadol absorption and elimination
Broberg, M. L., Holm, R., Jensen, K. G., Sveigaard, C., Larsen, Birger Brodin & Nielsen, C. U., 2010, In: European Journal of Pharmaceutical Sciences. 39, 1-3, p. 68-75Research output: Contribution to journal › Journal article › Research › peer-review
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mRNA expression and transport function of the proton-coupled amino acid transporter , PAT1, along the rat intestine
Broberg, M. L., Brandt Larsen, K., Holm, R., Larsen, Birger Brodin & Nielsen, C. U., Mar 2010. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Proton dependent transport of amino acids in Caco-2 cells
Broberg, M. L., Larsen, Birger Brodin & Nielsen, C. U., 2006. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Transport of Gaboxadol via hPAT1 and rOAT1 in the absence and presence of 5-HTP
Broberg, M. L., Holm, R., Larsen, Birger Brodin, Jensen, K. G. & Nielsen, C. U., 29 Jul 2009. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Intracellular calcium modulates basolateral K(+)-permeability in frog skin epithelium
Larsen, Birger Brodin, Rytved, K. A. & Nielsen, Rasmus, 1994, In: Pflügers Archiv - European Journal of Physiology. 426, 1-2, p. 171-3 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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In-vitro models of the blood brain barrier
Larsen, Birger Brodin, Helms, H. C. C., Groth, S., Waagepetersen, Helle S. & Nielsen, C. U., 2012. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Evidence for P2Y-type ATP receptors on the serosal membrane of frog skin eipthelium
Larsen, Birger Brodin & Nielsen, R., 2000, In: Pflügers Arch. (Eur. J. Physiol.). 439, p. 234-239Research output: Contribution to journal › Journal article › Research › peer-review
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Electrophysiological evidence for an ATP-gated ion channel in the principal cells of the frog skin epithelium
Larsen, Birger Brodin & Nielsen, R., 2000, In: Pflügers Archiv: European Journal of Physiology. 439, p. 227-233Research output: Contribution to journal › Journal article › Research › peer-review
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Transport of peptidomimetic drugs by the intestinal Di/tri-peptide transporter, PepT1
Larsen, Birger Brodin, Nielsen, C. U., Steffansen, B. & Frøkjær, Sven, 2002, In: Basic & Clinical Pharmacology & Toxicology. 90, 6, p. 285-96 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Small transepithelial osmotic gradients affect apical sodium permeability in frog skin.
Larsen, Birger Brodin & Nielsen, R., 1993, In: Pflugers Arch - European Journal of Physiology. 423, p. 411-417Research output: Contribution to journal › Journal article › Research › peer-review
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Peptide Transporters in Drug Delivery
Larsen, Birger Brodin, Steffansen, B. & Nielsen, C. U., 2007. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
Cypris ultrastructure, metamorphosis and sex in seven families of parasitic barnacles (Crustacea: Cirripedia: Rhizocephala)
Larsen, Birger Brodin, 1989, In: Acta Zoologica (Stockholm). 70, p. 229-242 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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An increase in [Ca2+]i activates basolateral chloride channels and inhibits apical sodium channels in frog skin epithelium
Larsen, Birger Brodin, Rytved, K. A. & Nielsen, Rasmus, 1996, In: Pflügers Archiv - European Journal of Physiology. 433, 1-2, p. 16-25 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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iP-gp , a novel cell line with tight barrier function and expression of human P-glycoprotein (ABCB1) for drug screening
Larsen, Birger Brodin, Ozgür, Burak & Saaby, Lasse, 23 May 2017.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Passive diffusion of drug substances: the concepts of flux and permeability
Larsen, Birger Brodin, Steffansen, B. & Nielsen, C. U., 2010, Molecular biopharmaceutics: Aspects of drug characterisation, drug delivery and dosage form evaluation. Steffansen, B., Brodin, B. & Nielsen, C. U. (eds.). PharmaPress Ltd., p. 135-151 16 p. (ULLA Pharmacy Series).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Phorbol Ester-Induced Metamorphosis in the Parasitic Barnacle, Loxothylacus Panopaei
Larsen, Birger Brodin, 1997, In: Journal of the Marine Biological Association of the United Kingdom. p. 261-264Research output: Contribution to journal › Journal article › Research › peer-review
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Proton-coupled basolateral dipeptide transport in a human intestinal cell line, Caco-2
Larsen, Birger Brodin, Nielsen, M. J. & Nielsen, C. U., 2007. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Evidence for P2Y-type ATP receptors on the serosal membrane of frog skin epithelium
Larsen, Birger Brodin & Nielsen, R., 1 Jan 2000, In: Pflugers Archiv European Journal of Physiology. 439, 3, p. 234-239 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Epidermal growth factor and insulin short-term increase hPEPT1-mediated glycylsarcosine uptake in Caco-2 cells
Larsen, Birger Brodin, Amstrup, J., Nielsen, C. U., Steffansen, B. & Frøkjær, S., 2003, In: Acta Physiol. Scandinavia. 178, p. 139-148Research output: Contribution to journal › Journal article › Research › peer-review
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Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D
Bräuner, Hans, Jensen, Anders A., Sheppard, P. O., Larsen, Birger Brodin, Krogsgaard-Larsen, Povl & O'Hara, P., 2001, In: BBA General Subjects. 1518, 3, p. 237-48 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Stimulation-induced increases in cerebral blood flow and local capillary vasoconstriction depend on conducted vascular responses
Cai, Changsi, Fordsmann, J. C., Jensen, S. H., Gesslein, B., wbh615, wbh615, Hald, B. O., Zambach, S. A., Larsen, Birger Brodin & Lauritzen, Martin, 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 25, p. E5796-E5804 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glutamate Efflux at the Blood-Brain Barrier: Cellular Mechanisms and Potential Clinical Relevance
Cederberg-Helms, H. C., Uhd-Nielsen, C. & Larsen, Birger Brodin, 15 Nov 2014, In: Archives of Medical Research. 45, 8, p. 639-645 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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In vitro blood-brain barrier permeability predictions for GABAA receptor modulating piperine analogs
Eigenmann, D. E., Dürig, C., Jähne, E. A., Smieško, M., Culot, M., Gosselet, F., Cecchelli, R., Helms, H. C. C., Larsen, Birger Brodin, Wimmer, L., Mihovilovic, M. D., Hamburger, M. & Oufir, M., Jun 2016, In: European Journal of Pharmaceutics and Biopharmaceutics. 103, p. 118-26 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Oral Gly-Sar absorption is inhibited bu a high-affinity PEPT1 inhibitor Lys-Z-NO2-Pro
Eriksson, A. H., Rist, G. M., Larsen, Birger Brodin & Steffansen, B., 2006. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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hPEPT1 Affinity and Translocation of Selected Gln-Sar and Glu-Sar Dipeptide Derivatives
Eriksson, A. H., Elm, P. L., Begtrup, M., Nielsen, R., Steffansen, B. & Larsen, Birger Brodin, 2005, In: Molecular Pharmaceutics. 2, 3, p. 242-249Research output: Contribution to journal › Journal article › Research › peer-review
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Pyrimidine and nucleoside gamma-esters of L-Glu-Sar: synthesis, stability and interaction with hPEPT1
Eriksson, A. H., Elm, P. L., Begtrup, M., Larsen, Birger Brodin, Nielsen, R. & Steffansen, B., 2005, In: European Journal of Pharmaceutical Sciences. 25, 1, p. 145-154 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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In-vitro evaluation of the P-glycoprotein interactions of a series of potentially CNS-active Amaryllidaceae alkaloids
Eriksson, A. H., Rønsted, Nina, Jäger, A. K., Sendra, J. R. & Larsen, Birger Brodin, 2012, In: Journal of Pharmacy and Pharmacology. 64, 11, p. 1667-1677 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The interaction of CNS-active Amaryllidae alkaloids with the BBB efflux pump MDR1
Eriksson, A. H., Birrer, A., Sendra, J. R., Güler, S., Rønsted, Nina, Jäger, A. K. & Larsen, Birger Brodin, 29 Jun 2010. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Particle size and surface charge affect particle uptake by human dendritic cells in an in vitro model
Foged, Camilla, Larsen, Birger Brodin, Frøkjær, Sven & Sundblad, A., 2005, In: Internation Journal of Pharmaceutics. 298, 2, p. 315-22 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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d-Aminolevulinic acid is a substrate for the amino acid transporter SLC36A1 (hPAT1)
Frølund, S., Marquez, O. C., Larsen, M., Larsen, Birger Brodin & Nielsen, C. U., 2010, In: British Journal of Pharmacology. 159, 6, p. 1339-1353Research output: Contribution to journal › Journal article › Research › peer-review
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The proton-coupled amino acid transporter, SLC36A1 (hPAT1), transports Gly-Gly, Gly-Sar and other Gly-Gly mimetics
Frølund, S., Holm, R., Larsen, Birger Brodin & Nielsen, C. U., 2010, In: British Journal of Pharmacology. 161, 3, p. 589-600Research output: Contribution to journal › Journal article › Research › peer-review
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Gly-sar is a substrate for the human proton coupled amino acid trasporter 1, hPAT1 (SLC36A1)
Frølund, S. B., Holm, R., Larsen, Birger Brodin & Nielsen, C. U., 2010.Research output: Contribution to conference › Poster › Research
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Gly-Sar is a substrate for the human proton-coupled amino acid transporter, hPAT1 (SLC36A1)
Frølund, S. B., Holm, R., Larsen, Birger Brodin & Nielsen, C. U., Mar 2010.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Potential involvement of the proton-coupled amino acid transporter PAT1 (SLC36A1) in the delivery of pharmaceutical agents
Frølund, S. B., Nøhr, M. K., Holm, R., Larsen, Birger Brodin & Nielsen, C. U., 2013, In: Journal of Drug Delivery Science and Technology. 23, 4, p. 293-306Research output: Contribution to journal › Journal article › Research › peer-review
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Highly cationic cell-penetrating peptides affect the barrier integrity and facilitates mannitol permeation in a human stem cell-based blood-brain barrier model
Frøslev, Patrick, Franzyk, Henrik, Ozgür, Burak, Larsen, Birger Brodin & Kristensen, Mie, 2022, In: European Journal of Pharmaceutical Sciences. 168, 10 p., 106054.Research output: Contribution to journal › Journal article › Research › peer-review
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Human induced pluripotent stem cells (BIONi010-C) generate tight cell monolayers with blood-brain barrier traits and functional expression of large neutral amino acid transporter 1 (SLC7A5)
Goldeman, C., Andersen, M., Al-Robai, A., Buchholtz, T., Svane, Nana Isabella, Ozgür, Burak, Holst, B., Shusta, E., Hall, Vanessa Jane, Saaby, Lasse, Hyttel, P. & Larsen, Birger Brodin, 2021, In: European Journal of Pharmaceutical Sciences. 156, 14 p., 105577.Research output: Contribution to journal › Journal article › Research › peer-review
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Initial Attempts of Development and Characterization of an In Vitro Blood Brain Barrier Model Derived from Human Pluripotent Stem Cells
Goldeman, C., Saaby, L., Hall, Vanessa Jane, Hyttel, P. & Larsen, Birger Brodin, 8 Dec 2016. 1 p.Research output: Contribution to conference › Poster › Research › peer-review
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Culture-induced changes in mRNA expression levels of efflux and SLC-transporters in brain endothelial cells
Goldeman, C., Ozgür, Burak & Larsen, Birger Brodin, 22 Apr 2020, In: Fluids and Barriers of the CNS. 17, 32, 12 p., 32.Research output: Contribution to journal › Journal article › Research › peer-review
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Development and Characterization of a Brain Endothelial Cell Phenotype using Human Induced Pluripotent Stem Cells
Goldeman, C., Saaby, L., Holst, B., Hall, Vanessa Jane, Hyttel, P. & Larsen, Birger Brodin, 2 Nov 2017.Research output: Contribution to conference › Poster › Research › peer-review
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Down-regulation of selected Blood-brain Barrier Specific Genes from Capillaries to Bovine In Vitro Models
Goldeman, C., Saaby, L. & Larsen, Birger Brodin, 14 Sep 2016. 1 p.Research output: Contribution to conference › Poster › Research › peer-review
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Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017
Greenwood, J., Hammarlund-Udenaes, M., Jones, H. C., Stitt, A. W., Vandenbrouke, R. E., Romero, I. A., Campbell, M., Fricker, G., Larsen, Birger Brodin, Manninga, H., Gaillard, P. J., Schwaninger, M., Webster, C., Wicher, K. B. & Khrestchatisky, M., 7 Nov 2017, In: Fluids and Barriers of the CNS. 14, 11 p., 31.Research output: Contribution to journal › Review › Research › peer-review
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Generation of a rat in-vitro blood-brain barrier model and initial insights on excitatory amino acid transporter expression
Groth, S., Moos, T., Helms, H. C. C. & Larsen, Birger Brodin, 2012. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories
Hayeshi, R., Hilgendorf, C., Arthursson, P., Augustijns, P., Larsen, Birger Brodin, Dehertogh, P., Fisher, K., Fossati, L., Hovenkamp, E., Korjamo, T., Masungi, C., Maubon, N., Mols, R., Mullertz, Anette , Mönkkönen, J., O´Driscoll, C., Oppers-Tiemissen, H. M., Ragnarsson, E. G. E., Rooseboom, M. & Ungell, A., 2008, In: European Journal of Pharmaceutical Sciences. 35, 5, p. 383-396Research output: Contribution to journal › Journal article › Research › peer-review
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Generation of primary cultures of bovine brain endothelial cells and setup of cocultures with rat astrocytes
Helms, H. C. & Larsen, Birger Brodin, 2014, In: Methods in molecular biology (Clifton, N.J.). 1135, p. 365-82 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of the L-glutamate clearance pathways across the blood-brain barrier and the effect of astrocytes in an in vitro blood-brain barrier model
Helms, H. C., Aldana, Blanca, Groth, S., Jensen, M. M., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 2017, In: Journal of Cerebral Blood Flow and Metabolism. 37, 12, p. 3744–3758Research output: Contribution to journal › Journal article › Research › peer-review
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In vitro evidence for the brain glutamate efflux hypothesis: brain endothelial cells cocultured with astrocytes display a polarized brain-to-blood transport of glutamate
Helms, H. C., Madelung, R., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 2012, In: Glia. 60, 6, p. 882-893Research output: Contribution to journal › Journal article › Research › peer-review
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An Electrically Tight In Vitro Blood-Brain Barrier Model Displays Net Brain-to-Blood Efflux of Substrates for the ABC Transporters, P-gp, Bcrp and Mrp-1
Helms, H. C., Hersom, M., Kuhlmann, L. B., Badolo, L., Nielsen, C. U. & Larsen, Birger Brodin, 17 Jun 2014, In: A A P S Journal. 16, 5, p. 1046-1055 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Paracellular tightness and claudin-5 expression is increased in the BCEC/Astrocyte blood-brain barrier model by increasing media buffer capacity during growth
Helms, H. C., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, Dec 2010, In: The AAPS Journal. 12, 4, p. 759-770Research output: Contribution to journal › Journal article › Research › peer-review
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Characterisation of in-vitro blood-brain barrier models
Helms, H. C., Eriksson, A. H., Waagepetersen, Helle S. & Larsen, Birger Brodin, 2009.Research output: Contribution to conference › Poster › Research
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In vitro models of the blood-brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use
Helms, H. C. C., Abbott, N. J., Burek, M., Cecchelli, R., Couraud, P., Deli, M. A., Förster, C., Galla, H. J., Romero, I. A., Shusta, E. V., Stebbins, M. J., Vandenhaute, E., Weksler, B. & Larsen, Birger Brodin, May 2016, In: Journal of Cerebral Blood Flow and Metabolism. 36, 5, p. 862-90 29 p.Research output: Contribution to journal › Review › Research › peer-review
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In vitro blood-brain barrier models
Helms, H. C. C., Eriksson, A. H., Nielsen, C. U., Waagepetersen, Helle S. & Larsen, Birger Brodin, 18 Jul 2009.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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In vitro evidence for the brain glutamate efflux hypothesis: brain endothelial cells co-cultured with astrocytes display a polarized brain-to-blood transport of glutamate
Helms, H. C. C., Madelung, R., Groth, S., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 13 Sep 2012. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Glutamate Transporters in the Blood-Brain Barrier
Helms, H. C. C., Nielsen, C. U., Waagepetersen, Helle S. & Larsen, Birger Brodin, 2017, Glial Amino Acid Transporters. Vol. 16. p. 297-314 18 p. (Advances in Neurobiology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Bovine endothelial/rat astrocyte co-cultures cultured in highly buffered media functionally express MDR1 and BCRP
Helms, H. C. C., Badolo, L., Kuhlmann, L. B. & Larsen, Birger Brodin, 21 Jun 2011.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Endothelial cell phenotype differs strongly between in viro BCEC monocultures and BCEC/rat astrocyte co-cultures, a phenomenon which may contribute to the differences in barrier tightness
Helms, H. C. C. & Larsen, Birger Brodin, 2013. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Transport pathways mediating blood-to-brain L-glutamate efflux
Helms, H. C. C., Nielsen, C. U., Waagepetersen, Helle S. & Larsen, Birger Brodin, 10 Dec 2014. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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The expression of Claudin-5 correlates with transendothelial electrical resistance (TEER) in BCEC/rat astrocyte blood-brain barrier models
Helms, H. C. C., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 2010.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Claudin-5 mRNA expression and transendothelial electrical resistance (TEER) correlate in the BCEC/astrocyte blood-brain barrier model
Helms, H. C. C., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 2010. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Characterization of in vitro blood-brain barrier models
Helms, H. C. C., Eriksson, A. H., Nielsen, C. U., Waagepetersen, Helle S., Walls, Anne Byriel & Larsen, Birger Brodin, 9 Aug 2009. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Excitatory amino acid transporter-1 (EAAT1) is the main transporter responsible for abluminal uptake of L-glutamate in bovine brain endothelial cells
Helms, H. C. C., Groth, S., Mikél, M., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 27 May 2013.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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A Tight Blood-Brain Barrier Model Displays Brain-to-Blood Efflux of Substrates for the ABC-Transporters, P-gp, BCRP and MRP-1
Helms, H. C. C., Hersom, M. N. S., Kuhlmann, L. B., Badolo, L., Nielsen, C. U. & Larsen, Birger Brodin, 11 Sep 2014. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Glutamate efflux from brain to blood - Studies in an in vitro blood-brain barrier model
Helms, H. C. C., Madelung, R., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 2012.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Efflux transporter expression in a tight in vitro model of the blood brain barrier
Helms, H. C. C., Hersom, M. N. S., Kuhlmann, L. B., Badolo, L., Nielsen, C. U. & Larsen, Birger Brodin, 10 Dec 2014. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Characterization of in-vitro blood-brain barrier models
Helms, H. C. C., Eriksson, A. H., Nielsen, C. U., Waagepetersen, Helle S. & Larsen, Birger Brodin, Aug 2009.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Transferrin receptor expression and role in transendothelial transport of transferrin in cultured brain endothelial monolayers
Hersom, M., Helms, H. C., Pretzer, N., Andersen, C. G., Jensen, A. I., Severin, G., Nielsen, M. S., Holm, R. & Larsen, Birger Brodin, 24 Aug 2016, In: Molecular and Cellular Neuroscience. 76, p. 59-67 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Validation of reference genes for normalization of real-time quantitative PCR studies of gene expression in brain capillary endothelial cells cultured in vitro
Hersom, M., Goldeman, C., Pretzer, N. & Larsen, Birger Brodin, Dec 2018, In: Molecular and Cellular Neuroscience. 93, p. 27-35 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The insulin receptor is expressed and functional in cultured blood-brain barrier endothelial cells, but does not mediate insulin entry from blood-to-brain
Hersom, M., Helms, H. C., Schmalz, C., Pedersen, T. Å., Buckley, S. T. & Larsen, Birger Brodin, 2018, In: American Journal of Physiology: Endocrinology and Metabolism. 315, 4, p. E531-E542Research output: Contribution to journal › Journal article › Research › peer-review
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The insulin receptor is expressed and functional in blood-brain barrier endothelial cells, but does not mediate insulin entry from blood-to-brain
Hersom, M. N. S., Helms, H. C. C., Pedersen, T., Buckley, S. & Larsen, Birger Brodin, 14 Sep 2016.Research output: Contribution to conference › Conference abstract for conference › Research
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Functional Insulin Receptor expression does not facilitate transendothelial passage of insulin in a bovine in vitro blood-brain barrier model
Hersom, M. N. S., Helms, H. C. C., Pedersen, T., Buckley, S. & Larsen, Birger Brodin, 3 Mar 2016.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Expression profiles of selected receptor systems in a bovine in vitro blood-brain barrier model
Hersom, M. N. S., Helms, H. C. C., Nielsen, M. S., Holm, R. & Larsen, Birger Brodin, 10 Dec 2014. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Expression and functional activity of the efflux transporters BCRP and P-gp in bovine endothelial cells, co-cultured with rat astrocytes
Hersom, M. N. S., Helms, H. C. C., Kuhlmann, L. B., Badolo, L. & Larsen, Birger Brodin, 2013. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Brain endothelial cells metabolize glutamate via glutamate dehydrogenase to replenish TCA-intermediates and produce ATP under hypoglycemic conditions
Hinca, S. B., Salcedo, C., Wagner, A., Goldeman, C., Sadat, E., Aibar, M. M. D., Maechler, P., Larsen, Birger Brodin, Aldana, Blanca & Helms, H. C. C., 2021, In: Journal of Neurochemistry. 157, 6, p. 1861-1875Research output: Contribution to journal › Journal article › Research › peer-review
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Subcellular trafficking and transcytosis efficacy of different receptor types for therapeutic antibody delivery at the blood‒brain barrier
Holst, M. R., de Wit, N. M., Ozgür, Burak, Brachner, A., Hyldig, K., Appelt-Menzel, A., Sleven, H., Cader, Z., de Vries, H. E., Neuhaus, W., Jensen, A., Larsen, Birger Brodin & Nielsen, M. S., 2023, In: Fluids and Barriers of the CNS. 20, 1, 17 p., 82.Research output: Contribution to journal › Journal article › Research › peer-review
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ATP induces contraction of cultured brain capillary pericytes, via activation of P2Y type purinergic receptors
Hørlyck, S., Cai, Changsi, Helms, H. C., Lauritzen, Martin & Larsen, Birger Brodin, 2021, In: American Journal of Physiology: Heart and Circulatory Physiology. 320, p. H699–H712 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Culture of brain capillary pericytes for cytosolic calcium measurements and calcium imaging studies
Hørlyck, S., Helms, H. C. C. & Larsen, Birger Brodin, May 2020, In: Journal of Visualized Experiments. 159, p. 1-9 9 p., e61253.Research output: Contribution to journal › Journal article › Research › peer-review
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Tanycytes Control the Hypothalamic Uptake and Metabolic Actions of Liraglutide
Imbernon, M., Saponaro, C., Helms, H. C. C., Zubiaga, L., Bitsi, S., Duquenne, M., Tomas, A., Chen, S., Salem, V., Deligia, E., Gmyr, V., Denis, R., Kerr-Conte, J., Chao, D. H. M., Beiroa, D., Steals, B., Pattou, F., Pfrieger, F., Brodin, B., Jones, B. & 3 others, , Jul 2021, In: Glia. 69, S1, p. E237-E237Research output: Contribution to journal › Conference abstract in journal › Research
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Tanycytes control hypothalamic liraglutide uptake and its anti-obesity actions
Imbernon, M., Saponaro, C., Helms, H. C. C., Duquenne, M., Fernandois, D., Deligia, E., Denis, R. G. P., Chao, D. H. M., Rasika, S., Staels, B., Pattou, F., Pfrieger, F. W., Larsen, Birger Brodin, Luquet, S., Bonner, C. & Prevot, V., 2022, In: Cell Metabolism. 34, 7, p. 1054-1063.e7Research output: Contribution to journal › Journal article › Research › peer-review
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PAT1 (SLC36A1) shows nuclear localization and affect growth of smooth muscle cells from rats
Jensen, A., Figueiredo-Larsen, E. M., Holm, R., Broberg, M. L., Larsen, Birger Brodin & Nielsen, C. U., Jan 2014, In: A J P: Endocrinology and Metabolism (Online). 306, p. E65-E74Research output: Contribution to journal › Journal article › Research › peer-review
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In vitro models for investigating the function of proton-coupled amino acid transporter 1 (PAT1, SLC36A19)
Jensen, A., Larsen, Birger Brodin & Nielsen, C. U., 2010. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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ATP induce intracellular calcium rises in cultures of primary brain pericytes
Jensen, S. H., Helms, H. C. C., Jessen, S. B., Lauritzen, Martin, Waagepetersen, Helle S. & Larsen, Birger Brodin, Jun 2016.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Rises in intracellular calcium in primary brain pericytes are caused by ATP
Jensen, S. H., Helms, H. C. C., Cai, Changsi, Lauritzen, Martin, Waagepetersen, Helle S. & Larsen, Birger Brodin, 2016. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Purinergic Signaling in Pericytes of the Blood-Brain Barrier
Jensen, S. H., Helms, H. C. C., Jessen, S. B., Lauritzen, Martin, Waagepetersen, Helle S. & Larsen, Birger Brodin, Jul 2015.Research output: Contribution to conference › Poster › Research › peer-review
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ATP induce an increase in intracellular Ca2+ in pericytes of the blood-brain barrier
Jensen, S. H., Helms, H. C. C., Jessen, S. B., Lauritzen, Martin, Waagepetersen, Helle S. & Larsen, Birger Brodin, 2 Nov 2015.Research output: Contribution to conference › Poster › Research › peer-review
- Published
Basolateral peptide transport in intestinal cells is pH dependent
Juul Nielsen, M., Nielsen, C. U. & Larsen, Birger Brodin, 2007. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Routes for drug translocation across the blood-brain barrier: Exploiting peptides as delivery vectors
Kristensen, Mie & Larsen, Birger Brodin, Sep 2017, In: Journal of Pharmaceutical Sciences. 106, 9, p. 2326-2334Research output: Contribution to journal › Review › Research › peer-review
- Published
Conjugation of Therapeutic PSD-95 Inhibitors to the Cell-Penetrating Peptide Tat Affects Blood-Brain Barrier Adherence, Uptake, and Permeation
Kristensen, Mie, Kucharz, Krzysztof, Alves Fernandes, Eduardo Felipe, Strømgaard, Kristian, Schallburg Nielsen, M., Cederberg Helms, H. C., Bach, Anders, Ulrikkaholm Tofte-Hansen, M., Aldana, Blanca, Lauritzen, Martin & Larsen, Birger Brodin, 2020, In: Pharmaceutics. 12, 7, 24 p., 661.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sorption and mobility of ivermectin in different soils
Krogh, K. A., Søborg, T., Larsen, Birger Brodin & Halling-Sørensen, B., 2008, In: Journal of Environmental Quality. 37, 6, p. 2202-2211Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Two-photon fluorescence imaging: a platform to investigate cell-penetrating peptides and liposome-based nanocarriers for drug delivery across the heterogeneous BBB in vivo
Kucharz, K., Kristensen, K., Kristensen, Mie, Lund, M., Andresen, T., Larsen, Birger Brodin & Lauritzen, M., 2019, In: Journal of Cerebral Blood Flow and Metabolism. 39, p. 60 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
ID: 1299175
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Design of prodrugs targeting the intestinal di/tri‐peptide transporter hPEPT1 (SLC15A1
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A bovine in vitro blood-brain barrier model under oxygenglucose deprivation (OGD) condition
Research output: Contribution to conference › Poster › Research
Published