In-vitro evaluation of the P-glycoprotein interactions of a series of potentially CNS-active Amaryllidaceae alkaloids

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Drug compounds interacting with the blood-brain barrier efflux transporter P-glycoprotein (P-gp) might have limited access to brain tissue. The aim of the present study was to evaluate whether nine potentially CNS-active Amaryllidaceae alkaloids of the crinine, lycorine and galanthamine types interact with P-gp.
Original languageEnglish
JournalJournal of Pharmacy and Pharmacology
Issue number11
Pages (from-to)1667-1677
Number of pages11
Publication statusPublished - 2012

ID: 44290044