Sven Frøkjær

Sven Frøkjær

Professor, emeritus

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    ORCID: 0000-0002-6621-3784

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    1. Published

      A calorimetric study of phosphocholine membranes mixed with desmopressin and its diacylated prodrug derivative (DPP)

      Pedersen, T. B., Frøkjær, Sven, Mouritsen, Ole G. & Jørgensen, K., 21 Feb 2002, In: International Journal of Pharmaceutics. 233, 1-2, p. 199-206 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      A helical structural nucleus is the primary elongating unit of insulin amyloid fibrils

      Vestergaard, Bente, Jensen, M. G., Roessle, M., Kastrup, Jette Sandholm Jensen, van de Weert, Marco, Flink, J. M., Frøkjær, Sven, Gajhede, Michael & Svergun, D. I., 2007, In: PLoS - Biology. 5, 5, p. 1089-1097

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Assessment of side-chain modified dipeptides that interact with the oligopeptide transporter

      Frøkjær, Sven, Steffansen, B. & Taub, M. E., 1998, Peptide and Protein Drug Delivery: Alfred Benzon Symposium 43. Munkgaard, p. 287-297 10 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    4. Published

      Association of acylated cationic decapeptides with dipalmitoylphosphatidylserine-dipalmitoylphosphatidylcholine lipid membranes

      Pedersen, T. B., Sabra, M. C., Frøkjær, Sven, Mouritsen, Ole G. & Jørgensen, K., 7 Nov 2001, In: Chemistry and Physics of Lipids. 113, 1-2, p. 83-95 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Association of an acylated model peptide with DPPC-DPPS lipid membranes

      Pedersen, T. B., Sabra, M. C., Frøkjær, Sven, Mouritsen, Ole G. & Jørgensen, K., 19 Feb 2001, In: International Journal of Pharmaceutics. 214, 1-2, p. 77-81 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Beta-carboxylic acid esterfied D-Asp-Ala retains a high affinity for the oligopeptide transporter in Caco-2 cell monolayers

      Taub, M. E., Larsen, B. D., Steffansen, B. & Frøkjær, Sven, 1997, In: International Journal of Pharmaceutics. 146, p. 205-212 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Binding mode of Thioflavin T in insulin amyloid fibrils

      Jensen, M. G., Norrman, M., Flink, J. M., van de Weert, Marco, Bukrinsky, J. T., Schluckebier, G. & Frøkjær, Sven, 2007, In: Journal of Structural Biology. 159, 3, p. 483-497

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Biologiske lægemidler - fra molekyle til medicin

      Nielsen, Hanne Mørck, Foged, Camilla, Jørgensen, Lene & Frøkjær, Sven, 2013, In: Lægemiddelforskning. p. 12-14

      Research output: Contribution to journal › Journal article › Research

    9. Published

      Biotechnology-based pharmaceuticals

      Jørgensen, Lene, Nielsen, Hanne Mørck & Frøkjær, Sven, 2009, Modern pharmaceutics: applications and advances. Florence, A. T. & Siepmann, J. (eds.). 5 ed. New York: Informa Healthcare, Vol. 2. p. 259-293 (Drugs and the Pharmaceutical Sciences, Vol. 188).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    10. Published

      Calcipotriol delivery into the skin with PEGylated liposomes

      Knudsen, N. Ø., Rønholt, Stine, Salte, R. D., Jørgensen, Lene, Thormann, T., Basse, L. H., Hansen, J., Frøkjær, Sven & Foged, Camilla, 2012, In: European Journal of Pharmaceutics and Biopharmaceutics. 81, 3, p. 532-9 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Cellular uptake and membrane-destabilising properties of a-peptide/ß-peptoid chimeras: lessons for the design of new cell-penetrating peptides

      Foged, Camilla, Franzyk, Henrik, Bahrami, S., Frøkjær, Sven, Jaroszewski, J. W., Nielsen, Hanne Mørck & Olsen, Christian Adam, 2008, In: BBA General Subjects. 1778, 11, p. 2487-2495

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Characterisation and physical stability of PEGylated glucagon

      Stigsnæs, P., Frøkjær, Sven, Bjerregaard, S., van de Weert, Marco, Kingshott, P. & Møller, E. H., 2007, In: Internation Journal of Pharmaceutics. 330, 1-2, p. 89-98

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Characterisation of salmon calcitonin in spray-dried powder for inhalation. Effect of chitosan

      Yang, Mingshi, Velaga, S., Yamamoto, H., Takeuchi, H., Kawashima, Y., Hovgaard, L., van de Weert, Marco & Frøkjær, Sven, 2007, In: Internation Journal of Pharmaceutics. 331, 2, p. 176-181

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Characterization of rPEPT2-mediated Gly-Sar transport parameters in the rat kidney proximal tubule cell line SKPT-0193 cl.2 cultured in basic growth media

      Bravo, S. A., Nielsen, C. U., Frøkjær, Sven & Larsen, Birger Brodin, 2005, In: Molecular Pharmaceutics. 2, 2, p. 98-108 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Chemical and thermal stability of insulin: effects of zinc and ligand binding to the insulin zinc-hexamer

      Huus, K., Havelund, S., Olsen, H. B., van de Weert, Marco & Frøkjær, Sven, Nov 2006, In: Pharmaceutical Research. 23, 11, p. 2611-20 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Cloning of the pig PEPT2 (pPEPT2) and characterization of the effects of epidermal growth factor (EGF) on pPEPT2-mediated peptide uptake in the renal porcine cell line LLC-PK1

      Søndergaard, H. B., Bravo, S. A., Nielsen, C. U., Frøkjær, Sven & Larsen, Birger Brodin, 2008, In: European Journal of Pharmaceutical Sciences. 33, 4-5, p. 332-342

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Complex coacervation of lysozyme and heparin: complex characterization and protein stability

      van de Weert, Marco, Andersen, M. B. & Frøkjær, Sven, Dec 2004, In: Pharmaceutical Research. 21, 12, p. 2354-9 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Complex coacervation with heparin results in decreased lysozyme stability

      van de Weert, Marco, Bendix Andersen, M. & Frøkjær, Sven, 3 Jan 2005, In: Journal of controlled release : official journal of the Controlled Release Society. 101, 1-3, p. 361-2 2 p.

      Research output: Contribution to journal › Conference abstract in journal › Research

    19. Published

      Computational prediction of solubilizers' effect on partitioning

      Høst, J., Christensen, I. T., Jørgensen, Flemming Steen, Frøkjær, Sven & Hovgaard, L., 2007, In: Internation Journal of Pharmaceutics. 329, 1-2, p. 46-52

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Danish Physicians’ Views on the Appropriateness of the Involvement of Patients with Type 2 Diabetes in Regulatory Decision Making: A Qualitative Study

      Sachs, M. L., Colding-Jørgensen, M., Helboe, P., Kälvemark Sporrong, Sofia, Frøkjær, Sven, Jelic, K. & Kaae, Susanne, 2019, In: Pharmaceutical Medicine. 33, 2, p. 99-107

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Data-enriched edible pharmaceuticals (DEEP) of medical cannabis by inkjet printing

      Öblom, H., Cornett, Claus, Bøtker, Johan Peter, Frøkjær, Sven, Hansen, Harald S., Rades, Thomas, Rantanen, Jukka & Genina, Natalja, 2020, In: International Journal of Pharmaceutics. 589, p. 1-11 119866.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Delivery aspects of small peptides and substrates for peptide transporters

      Steffansen, B., Nielsen, C. U. & Frøkjær, Sven, 2005, In: European Journal of Pharmaceutics and Biopharmaceutics. 60, 4, p. 241-245 4 p.

      Research output: Contribution to journal › Review › Research › peer-review

    23. Published

      Den danske kodeks for integritet i forskning

      Pedersen, H. M., Frøkjær, Sven, Bach, L. W., Vestergaard, E., Pedersen, C. V., Dirckinck-Holmfeld, L., Wegener, H. C., Jensen, L., Staunstrup, J. & Hansen, J. M., 2015

      Research output: Book/Report › Report › Communication

    24. Published

      Design of cyclic RKKH peptide-conjugated PEG liposomes targeting the integrin a2ß1 receptor

      Knudsen, N. Ø., Schiffelers, R. M., Jørgensen, Lene, Hansen, J., Frøkjær, Sven & Foged, Camilla, 2012, In: International Journal of Pharmaceutics. 428, 1-2, p. 171-177

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Dipeptide model prodrugs for the intestinal oligopeptide transporter. Affinity for and transport via hPepT1 in the human intestinal Caco-2 cell line

      Nielsen, C. U., Andersen, R., Larsen, Birger Brodin, Frøkjær, Sven, Taub, M. E. & Steffansen, B., 2001, In: Journal of Controlled Release. 76, 1-2, p. 129-38 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Drug delivery by phospholipase A2 degradable liposomes

      Davidsen, J., Vermehren, Charlotte, Frøkjær, Sven, Mouritsen, Ole G. & Jørgensen, K., 19 Feb 2001, In: International Journal of Pharmaceutics. 214, 1-2, p. 67-69 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Drug delivery studies in Caco-2 monolayers V. Ethyl glucoside esters as a novel type of absorption enhancers

      Nielsen, Hanne Mørck, Brøndsted, H., Frøkjær, Sven & Hovgaard, L., 1 Mar 1996, In: S.T.P. Pharma Sciences. 6, 2, p. 157-161 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Drug delivery studies in Caco-2 monolayers. IV. Ethyl glycoside esters as a novel type of absorption enhancers.

      Nielsen, Hanne Mørck, Brøndsted, H., Frøkjær, Sven & Hovgaard, L., 1996, In: STP pharma sciences. p. 157-161

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Effects of sucrose on rFVIIa aggregation and methionine oxidation

      Soenderkaer, S., Carpenter, J. F., van de Weert, Marco, Hansen, L. L., Flink, J. & Frøkjær, Sven, Apr 2004, In: European Journal of Pharmaceutical Sciences. 21, 5, p. 597-606 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Enzymatic degradation of polymer covered SOPC-liposomes in relation to drug delivery

      Davidsen, Johan, Vermehren, Charlotte, Frøkjær, Sven, Mouritsen, Ole G. & Jørgensen, K., 29 Jan 2001, In: Advances in Colloid and Interface Science. 89-90, p. 303-311 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Epidermal growth factor decreases PEPT2 transport capacity and expression in the rat kidney proximal tubule cell line SKPT0193 cl.2

      Bravo, S. A., Nielsen, C. U., Amstrup, J., Frøkjær, Sven & Larsen, Birger Brodin, 2004, In: American Journal of Physiology - Renal Physiology. 286, 2, p. 385-393

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Epidermal growth factor inhibits glycylsarcosine transport and hPepT1 expression in a human intestinal cell line

      Nielsen, C. U., Amstrup, J., Steffansen, B., Frøkjær, Sven & Larsen, Birger Brodin, 2001, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 281, 1, p. G191-9

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Erratum: Prodrugs of purine and pyrimidine analogues for the intestinal di/tri-peptide transporter PepT1: Affinity for hPepT1 in Caco-2 cells, drug release in aqueous media and in vitro metabolism (Journal of Controlled Release (2003) 86 (279-292) PII: S0168365902004133)

      Thomsen, A. E., Friedrichsen, G. M., Sørensen, A. H., Andersen, R., Nielsen, C. U., Larsen, Birger Brodin, Begtrup, M., Frøkjær, Sven & Steffansen, B., 7 Mar 2003, In: Journal of Controlled Release. 88, 2

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Evaluation of statistical design/modeling for prediction of the effect of amino acids on agitation-induced aggregation of human growth hormone and human insulin

      Soenderkaer, S., van de Weert, Marco, Lindgaard Hansen, L., Flink, J. & Frøkjær, Sven, 2005, In: Journal of Drug Delivery Science and Technology. 15, 6, p. 427-434 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Factors of importance for a successful delivery system for proteins

      van de Weert, Marco, Jørgensen, Lene, Horn Moeller, E. & Frøkjær, Sven, Nov 2005, In: Expert Opinion on Drug Delivery. 2, 6, p. 1029-37 9 p.

      Research output: Contribution to journal › Review › Research › peer-review

    36. Published

      Formation mechanism of insulin fibrils and structural aspects of the insulin fibrillation process

      Jensen, M. G., Frøkjær, Sven & Vestergaard, Bente, 2009, In: Current Protein and Peptide Science. 10, 5, p. 509-528

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Formulation, stability and characterization of protein and peptide drugs

      Frøkjær, Sven, Hovgaard, L. & van de Weert, Marco, 2004, Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids. Mahato, R. I. (ed.). Boca Raton: CRC Press, p. 378-401

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication

    38. Published

      Gennembrud i forståelsen af insulinfibrillering

      Jensen, M. G., Vestergaard, Bente, Frøkjær, Sven, Gajhede, Michael, Flink, J. M., van de Weert, Marco, Kastrup, Jette Sandholm Jensen & Svergun, D. I., 2007, In: Lægemiddelforskning. p. 10-11

      Research output: Contribution to journal › Journal article › Communication

    39. Published

      Guidance for pediatric use in prescription information for novel medicinal products in the EU and the US

      Christiansen, H., De Bruin, M. L., Frøkjær, Sven & Hallgreen, Christine Erikstrup, 2022, In: PLoS ONE. 17, 4, 19 p., e0266353.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Human peptide transporters: Therapeutic applications

      Nielsen, C. U., Larsen, Birger Brodin, Jørgensen, Flemming Steen, Frøkjær, Sven & Steffansen, B., 1 Sep 2002, In: Expert Opinion on Therapeutic Patents. 12, 9, p. 1329-1350 22 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      I-125 used for labelling of proteins in an absorption model changes the absorption rate of insulin aspart

      Søhoel, A., Plum, A., Frøkjær, Sven & Thygesen, P., 2007, In: Internation Journal of Pharmaceutics. 330, 1-2, p. 114-120

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      In vitro and in vivo aspects of N-acyl-phosphatidylethanolamine-containing liposomes

      Vermehren, Charlotte, Clausen-Beck, B., Frøkjær, Sven & Hansen, Harald S., 18 Mar 2003, In: International Journal of Pharmaceutics. 254, 1, p. 49-53 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      In vitro evaluation of N-methyl amide tripeptidomimetics as substrates for the human intestinal di-/tri-peptide transporter hPEPT1

      Andersen, R., Nielsen, C. U., Begtrup, M., Jørgensen, Flemming Steen, Larsen, Birger Brodin, Frøkjær, Sven & Steffansen, B., 2006, In: European Journal of Pharmaceutical Sciences. 28, 4, p. 325-35 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      In vitro release of insulin aspart incorporated into water-in-oil emulsions

      Jørgensen, Lene, Vermehren, Charlotte, Bjerregaard, S. & Frøkjær, Sven, 2004, In: Journal of Drug Delivery Science and Technology. 14, 6, p. 455-459

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      In-depth evaluation of Gly-Sar transport parameters as a function of culture time in the Caco-2 cell model

      Bravo, S. A., Nielsen, C. U., Amstrup, J., Frøkjær, Sven & Larsen, Birger Brodin, 1 Jan 2004, In: European Journal of Pharmaceutical Sciences. 21, 1, p. 77-86 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Influence of PEGylation with linear and branched PEG chains on the adsorption of glucagon to hydrophobic surfaces

      Pinholt, C., Bukrinsky, J. T., Hostrup, S., Frøkjær, Sven, Norde, W. & Jørgensen, Lene, 2011, In: European Journal of Pharmaceutics and Biopharmaceutics. 77, 1, p. 139-147

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Influence of acylation on the adsorption of GLP-2 to hydrophobic surfaces

      Pinholt, C., Kapp, S. J., Bukrinsky, J. T., Hostrup, S., Frøkjær, Sven, Norde, W. & Jørgensen, Lene, 2013, In: International Journal of Pharmaceutics. 440, 1, p. 63-71 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Influence of acylation on the adsorption of insulin to hydrophobic surfaces

      Pinholt, C., Hostrup, S., Bukrinsky, J. T., Frøkjær, Sven & Jørgensen, Lene, 2011, In: Pharmaceutical Research. 28, p. 1031-1040

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Influence of glycosylation on the adsorption of Thermomyces lannuginosus lipase to hydrophobic and hydrophilic surfaces

      Pinholt, C., Fanø, M., Wiberg, C., Hostrup, S., Bukrinsky, J. T., Frøkjær, Sven, Norde, W. & Jørgensen, Lene, 2010, In: European Journal of Pharmaceutical Sciences. 40, 4, p. 273-281

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Influence of oligopeptide transporter binding affinity upon uptake and transport of D-Asp(Obzl)-Ala and Asp(OBzl)-Sar in filter-grown Caco-2 monolayers

      Taub, M. E., Moss, B. A., Steffansen, B. & Frøkjær, Sven, 1997, In: International Journal of Pharmaceutics. 156, p. 219-228 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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