Factors of importance for a successful delivery system for proteins
Research output: Contribution to journal › Review › Research › peer-review
Protein pharmaceuticals have matured into an important class of drugs, now comprising one in three novel drugs introduced on the market. However, significant gains are still to be made in reducing the costs of production, ensuring proper pharmacokinetics and efficacy, increasing patient compliance and convenience, and reducing side effects such as immunogenicity. This review summarises these issues and provides recent examples of methods to reduce costs, alter pharmacokinetics and increase patient compliance. It also discusses the increasing interest in understanding immunogenicity in order to prevent failure of the protein drug or serious life-threatening side effects due to autoimmunogenicity.
|Journal||Expert Opinion on Drug Delivery|
|Number of pages||9|
|Publication status||Published - Nov 2005|
- Animals, Antibody Formation, Chemistry, Pharmaceutical, Drug Administration Routes, Drug Delivery Systems, Drug Stability, Erythropoietin, Humans, Patient Compliance, Proteins, Recombinant Proteins, Red-Cell Aplasia, Pure