Factors of importance for a successful delivery system for proteins

Research output: Contribution to journalReviewResearchpeer-review

Protein pharmaceuticals have matured into an important class of drugs, now comprising one in three novel drugs introduced on the market. However, significant gains are still to be made in reducing the costs of production, ensuring proper pharmacokinetics and efficacy, increasing patient compliance and convenience, and reducing side effects such as immunogenicity. This review summarises these issues and provides recent examples of methods to reduce costs, alter pharmacokinetics and increase patient compliance. It also discusses the increasing interest in understanding immunogenicity in order to prevent failure of the protein drug or serious life-threatening side effects due to autoimmunogenicity.
Original languageEnglish
JournalExpert Opinion on Drug Delivery
Issue number6
Pages (from-to)1029-37
Number of pages9
Publication statusPublished - Nov 2005

    Research areas

  • Animals, Antibody Formation, Chemistry, Pharmaceutical, Drug Administration Routes, Drug Delivery Systems, Drug Stability, Erythropoietin, Humans, Patient Compliance, Proteins, Recombinant Proteins, Red-Cell Aplasia, Pure

ID: 44640488