Factors of importance for a successful delivery system for proteins
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Factors of importance for a successful delivery system for proteins. / van de Weert, Marco; Jorgensen, Lene; Horn Moeller, Eva; Frokjaer, Sven.
In: Expert Opinion on Drug Delivery, Vol. 2, No. 6, 11.2005, p. 1029-37.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Factors of importance for a successful delivery system for proteins
AU - van de Weert, Marco
AU - Jorgensen, Lene
AU - Horn Moeller, Eva
AU - Frokjaer, Sven
PY - 2005/11
Y1 - 2005/11
N2 - Protein pharmaceuticals have matured into an important class of drugs, now comprising one in three novel drugs introduced on the market. However, significant gains are still to be made in reducing the costs of production, ensuring proper pharmacokinetics and efficacy, increasing patient compliance and convenience, and reducing side effects such as immunogenicity. This review summarises these issues and provides recent examples of methods to reduce costs, alter pharmacokinetics and increase patient compliance. It also discusses the increasing interest in understanding immunogenicity in order to prevent failure of the protein drug or serious life-threatening side effects due to autoimmunogenicity.
AB - Protein pharmaceuticals have matured into an important class of drugs, now comprising one in three novel drugs introduced on the market. However, significant gains are still to be made in reducing the costs of production, ensuring proper pharmacokinetics and efficacy, increasing patient compliance and convenience, and reducing side effects such as immunogenicity. This review summarises these issues and provides recent examples of methods to reduce costs, alter pharmacokinetics and increase patient compliance. It also discusses the increasing interest in understanding immunogenicity in order to prevent failure of the protein drug or serious life-threatening side effects due to autoimmunogenicity.
KW - Animals
KW - Antibody Formation
KW - Chemistry, Pharmaceutical
KW - Drug Administration Routes
KW - Drug Delivery Systems
KW - Drug Stability
KW - Erythropoietin
KW - Humans
KW - Patient Compliance
KW - Proteins
KW - Recombinant Proteins
KW - Red-Cell Aplasia, Pure
U2 - 10.1517/17425247.2.6.1029
DO - 10.1517/17425247.2.6.1029
M3 - Review
C2 - 16296807
VL - 2
SP - 1029
EP - 1037
JO - Expert Opinion on Drug Delivery
JF - Expert Opinion on Drug Delivery
SN - 1742-5247
IS - 6
ER -
ID: 44640488