Stine Rønholt

Stine Rønholt

Assistant professor, tenure track

My research aim is cross-disciplinary focusing on the interface between physical chemistry, biophysics, biology and pharmaceutical sciences. I explore the barrier interactions between biological membranes, the skin and mucus barrier, and advanced drug delivery systems (DDS) or components hereof e.g., permeation enhancers and solid-state formulations intended for delivery of biopharmaceuticals. My research includes small as well as large molecules. I have a particular interest in how diseases in the barrier affects drug uptake and barrier interaction. By combining advanced biophysical techniques such as synchrotron X-ray and neutron scattering, rheology, rheo-microscopy, advanced microscopy (cryo-SEM and TEM) and thermal characterization with in vitro and in vivo models, I am currently developing a multimodal research platform to explore interactions between the skin barrier and delivery systems being deep eutectics and ionic liquids.

Selected publications

  1. Published

    Cell-penetrating peptides as carriers for transepithelial drug delivery in vitro

    Harloff-Helleberg, Stine, Kristensen, Mie & Nielsen, Hanne Mørck, 2015, Cell-penetrating peptides : Methods and Protocols. Langel, Ü. (ed.). Vol. 1324. p. 261-277 17 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  2. Published

    The effect of butter grains on physical properties of butter-like emulsions

    Harloff-Helleberg, Stine, Buldo, P., Mortensen, Kell, Andersen, U., Knudsen, J. C. & Wiking, L., 2014, In: Journal of Dairy Science. 97, 4, p. 1929-1938 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Metodeudvikling: Reologi til bestemmelse af fedtbaserede produkters materialeegenskaber

    Harloff-Helleberg, Stine, Knudsen, J. C. & Mortensen, Kell, 2013, In: Dansk Kemi. 94, 11, p. 33-34 2 p.

    Research output: Contribution to journalJournal articleCommunication

  4. Published

    Fat crystallization in dairy products: Rheology and microstructure of fat crystals

    Harloff-Helleberg, Stine, 2013, Department of Food Science, University of Copenhagen. 283 p.

    Research output: Book/ReportPh.D. thesisResearch

  5. Published

    Effect of cream cooling rate and water content on butter microstructure during four weeks of storage

    Harloff-Helleberg, Stine, Kirkensgaard, Jacob Judas Kain, Mortensen, Kell & Knudsen, J. C., 2014, In: Food Hydrocolloids. 34, p. 169-176 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    The effect of capacity, rotational speed and storage on crystallization and rheological properties of puff pastry butter

    Harloff-Helleberg, Stine, Kirkensgaard, Jacob Judas Kain, Høyer, K. F., Mortensen, Kell & Knudsen, J. C., 2014, In: Journal of the American Oil Chemists' Society. 91, 1, p. 29-38

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    The effective factors on the structure of butter and other milk fat-based products

    Harloff-Helleberg, Stine, Mortensen, Kell & Knudsen, J. C., 2013, In: Comprehensive Reviews in Food Science and Food Safety. 12, 5, p. 468-482 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Small deformation rheology for characterization of anhydrous milk fat/rapeseed oil samples

    Harloff-Helleberg, Stine, Mortensen, Kell & Knudsen, J. C., 2014, In: Journal of Texture Studies. 45, 1, p. 20-29 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Polymorphism, microstructure and rheology of butter. Effects of cream heat treatment

    Harloff-Helleberg, Stine, Kirkensgaard, Jacob Judas Kain, Pedersen, T. B., Mortensen, Kell & Knudsen, J. C., 2012, In: Food Chemistry. 135, 3, p. 1730-1739 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Microstructural and rheological characterization of fat crystals

    Harloff-Helleberg, Stine, Mortensen, Kell, Hassenkam, Tue & Knudsen, J. C., 2010. 1 p.

    Research output: Contribution to conferencePosterResearch

  11. Published

    Calcipotriol delivery into the skin with PEGylated liposomes

    Knudsen, N. Ø., Harloff-Helleberg, Stine, Salte, R. D., Jørgensen, Lene, Thormann, T., Basse, L. H., Hansen, J., Frøkjær, Sven & Foged, Camilla, 2012, In: European Journal of Pharmaceutics and Biopharmaceutics. 81, 3, p. 532-9 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Lipid-protein interactions in nanodiscs: how to enhance stability

    Wadsäter, M. H., Cardenas Gomez, M., Harloff-Helleberg, Stine, Maric, S., Skar-Gislinge, Nicholas, Midtgaard, S. R., Arleth, Lise, Mortensen, Kell, Ryan, R. O. & Simonsen, J. B., 2012, In: Biophysical Journal. 102, 3, p. 236a 1 p.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  13. Published

    Fedtstruktur: innovation af smør og blandingsprodukter

    Harloff-Helleberg, Stine, Knudsen, J. C., Mortensen, Kell, Kaufmann, N., Buldo, P., Wiking, L. & Andersen, U., 2012, In: Maelkeritidende. 6, p. 8-9 2 p.

    Research output: Contribution to journalJournal articleResearch

  14. Published

    Danmark kan lære meget af australske erfaringer med klinisk farmaci

    Harloff-Helleberg, Stine, 2008, In: Pharma. 7, p. 32-34 3 p.

    Research output: Contribution to journalJournal articleCommunication

Selected activities

  1. 2014 AAPS Annual meeting and EXPO

    Harloff-Helleberg, Stine (Speaker)

    2 Nov 20146 Nov 2014

    Activity: Participating in an event - typesParticipation in workshop, seminar, course

  2. COMPACT

    Harloff-Helleberg, Stine (Speaker)

    3 Feb 20155 Feb 2015

    Activity: Participating in an event - typesParticipation in workshop, seminar, course

  3. EUPATI

    Harloff-Helleberg, Stine (Speaker)

    1 Jan 2014 → …

    Activity: Participating in an event - typesParticipation in workshop, seminar, course

  4. Cell Penetrating Peptides

    Harloff-Helleberg, Stine (Participant)

    7 Oct 201313 Oct 2013

    Activity: Participating in an event - typesParticipation in workshop, seminar, course

ID: 18182987