Lene Jørgensen

Lene Jørgensen

Associate Professor

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    1. Published

      A synthetic mycobacterial monomycoloyl glycerol analogue stabilizes DDA liposomes

      Nordly, P. J., Pedersen, E. A., Khiljii, T. S., Agger, E. M., Jørgensen, Lene, Nielsen, Hanne Mørck, Korsholm, K. S., Franzyk, Henrik & Foged, Camilla, 2010, In: CRS Newsletter. 27, 2, p. 12 14 p.

      Research output: Contribution to journal › Journal article › Research

    2. Published

      Adsorption of insulin with varying self-association profiles to a solid Teflon surface-Influence on protein structures, fibrillation tendency and thermal stability

      Jørgensen, Lene, Bennedsen, P., Hoffmann, S. V., Pinholt, C., Krogh, R. L., Jensen, M. G., Hostrup, S. & Burkinksky, J. T., 2011, In: European Journal of Pharmaceutical Sciences. 42, 5, p. 509-516

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Alternative routes of administration for systemic delivery of protein pharmaceuticals

      Møller, E. H. & Jørgensen, Lene, 2008, In: Drug Discovery Today: Technologies. 5, 2-3, p. 89-94

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Analysis of protein physical stability in lipid based delivery systems: the challenges of lipid drug delivery systems

      Jørgensen, Lene, Martins, S. & van de Weert, Marco, 2009, In: Journal of Biomedical Nanotechnology. 5, 4, p. 401-408

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Attenuated Total Reflection Fourier Transform Infrared (ATR FT-IR) Spectroscopy as an Analytical Method to Investigate the Secondary Structure of a Model Protein Embedded in Solid Lipid Matrices

      Zeeshan, F., Tabbassum, M., Jørgensen, Lene & Medlicott, N. J., 2018, In: Applied Spectroscopy. 72, 2, p. 268-279 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Biodegradable nanocomposite microparticles as drug delivering injectable cell scaffolds

      Wen, Y., Gallego, M. R., Nielsen, L. F., Jørgensen, Lene, Everland, H., Møller, E. H. & Nielsen, Hanne Mørck, 2011, In: Journal of Controlled Release. 156, 1, p. 11-20

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Biologiske lægemidler - fra molekyle til medicin

      Nielsen, Hanne Mørck, Foged, Camilla, Jørgensen, Lene & Frøkjær, Sven, 2013, In: Lægemiddelforskning. p. 12-14

      Research output: Contribution to journal › Journal article › Research

    8. Published

      Biotechnology-based pharmaceuticals

      Jørgensen, Lene, Nielsen, Hanne Mørck & Frøkjær, Sven, 2009, Modern pharmaceutics: applications and advances. Florence, A. T. & Siepmann, J. (eds.). 5 ed. New York: Informa Healthcare, Vol. 2. p. 259-293 (Drugs and the Pharmaceutical Sciences, Vol. 188).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    9. Published

      Calcipotriol delivery into the skin with PEGylated liposomes

      Knudsen, N. Ø., Rønholt, Stine, Salte, R. D., Jørgensen, Lene, Thormann, T., Basse, L. H., Hansen, J., Frøkjær, Sven & Foged, Camilla, 2012, In: European Journal of Pharmaceutics and Biopharmaceutics. 81, 3, p. 532-9 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Challenges in Delivery of Biopharmaceuticals; the Need for Advanced Delivery Systems

      Nielsen, Hanne Mørck & Jørgensen, Lene, 11 Dec 2009, Delivery Technologies for Biopharmaceuticals: Peptides, Proteins, Nucleic Acids and Vaccines. John Wiley & Sons, Ltd, p. 1-8 8 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    11. Published

      Comparison of two methods detecting lysozyme adsorption to oil-water interface in the presence of surfactants

      Baldursdottir, S. G. & Jørgensen, Lene, 2012. 1 p.

      Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

    12. Published

      Competitive adsorption of monoclonal antibodies and nonionic surfactants at solid hydrophobic surfaces

      Kapp, S. J., Larsson, I., van de Weert, Marco, Cardenas Gomez, M. & Jørgensen, Lene, 2015, In: Journal of Pharmaceutical Sciences. 104, 2, p. 593-601 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Complex coacervates of hyaluronic acid and lysozyme: Effect on protein structure and physical stability

      Water, J. J., Schack, M. M., Velazquez-Campoy, A., Maltesen, M. J., van de Weert, Marco & Jørgensen, Lene, 1 Jan 2014, In: European Journal of Pharmaceutics and Biopharmaceutics. 88, 2, p. 325-331 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Correlation between calculated molecular descriptors of excipient amino acids and experimentally observed thermal stability of lysozyme

      Meng-Lund, H., Friis, N., van de Weert, Marco, Rantanen, Jukka, Poso, A., Grohganz, Holger & Jørgensen, Lene, 15 May 2017, In: International Journal of Pharmaceutics. 523, 1, p. 238-245 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Correlation between enzyme activity an stability of a protease, an alpha-amaylase and a lipase in a simplified liquid laundry detergent system, determined by differential scanning calorimetry

      Lund, H., Kaasgaard, S. G., Skagerlind, P., Jørgensen, Lene, Jørgensen, C. I. & van de Weert, Marco, 2012, In: Journal of Surfactants and Detergents. 15, p. 9-21

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Delivery of dermatan sulfate from polyelectrolyte complex-containing alginate composite microspheres for tissue regeneration

      Wen, Y., Grøndahl, L., Gallego, M. R., Jørgensen, Lene, Møller, E. H. & Nielsen, Hanne Mørck, 2012, In: Biomacromolecules. 13, p. 905-917

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Delivery technologies for biopharmaceuticals: Peptides, proteins, nucleic acids and vaccines

      Jørgensen, Lene & Nielsen, Hanne Mørck, 2009, Wiley. 413 p.

      Research output: Book/Report › Book › Research › peer-review

    18. Published

      Design and characterization of core-shell mPEG-PLGA composite microparticles for development of cell-scaffold constructs

      Wen, Y., Gallego, M. R., Nielsen, L. F., Jørgensen, Lene, Møller, E. H. & Nielsen, Hanne Mørck, Sep 2013, In: European Journal of Pharmaceutics and Biopharmaceutics. 85, 1, p. 87-98 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Design and processing of nanogels as delivery systems for peptides and proteins: Therapeutic Delivery

      Arnfast, L., Madsen, C. G., Jørgensen, Lene & Baldursdottir, S., 1 Jun 2014, In: Therapeutic Delivery. 5, 6, p. 691-708 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Design of cyclic RKKH peptide-conjugated PEG liposomes targeting the integrin a2ß1 receptor

      Knudsen, N. Ø., Schiffelers, R. M., Jørgensen, Lene, Hansen, J., Frøkjær, Sven & Foged, Camilla, 2012, In: International Journal of Pharmaceutics. 428, 1-2, p. 171-177

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Determination of liposome-buffer distribution coefficients of charged drugs by capillary electrophoresis frontal analysis

      Franzen, U., Jørgensen, Lene, Larsen, C. S., Heegaard, N. H. H. & Østergaard, Jesper, 2009, In: Electrophoresis. 30, 15, p. 2711-2719

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Development of biodegradable nanocomposite scaffolds for autologous cell therapy

      Wen, Y., Gallego, M. R., Nielsen, L. F., Jørgensen, Lene, Everland, H., Møller, E. H. & Nielsen, Hanne Mørck, 1 Jan 2011, In: European Cells and Materials. 21, SUPPL.1, 1 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Drug - liposome distribution phenomena studied by capillary electrophoresis-frontal analysis

      Østergaard, Jesper, Jørgensen, Lene, Thomsen, A. E., Larsen, Susan Weng, Larsen, C. S. & Jensen, H., 2008, In: Electrophoresis. 29, 16, p. 3320 - 3324

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Effect of mixed solvents on polymer conformation –correlation between the Hildebrand/Hansen solubility parameters and the intrinsic viscosity of polymer solutions

      Madsen, C. G., Skov, A., Jørgensen, Lene, Baldursdottir, S. G. & Medlicott, N., 2013, In: Nordic Rheology Society Annual Transactions. 21, p. 354-352

      Research output: Contribution to journal › Conference article › Research

    25. Published

      Elucidating the mechanisms of protein antigen adsorption to the CAF/NAF liposomal vaccine adjuvant systems: Effect of charge, fluidity and antigen-to-lipid ratio

      Hamborg, M., Rose, F., Jørgensen, Lene, Bjorklund, K., Pedersen, H., Christensen, D. & Foged, Camilla, 25 Apr 2014, In: BBA General Subjects. 1838, 8, p. 2001-2010 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Erratum: Kapp SJ, Larsson I, Van De Weert M, Ćardenas M, Jorgensen L. 2015. Competitive Adsorption of Monoclonal Antibodies and Nonionic Surfactants at Solid Hydrophobic Surfaces. 2015. J Pharm Sci 104:593-601

      Kapp, S. J., Larsson, I., van de Weert, Marco, Ćardenas, M. & Jørgensen, Lene, 2015, In: Journal of Pharmaceutical Sciences. 104, 10, p. 3587 1 p.

      Research output: Contribution to journal › Comment/debate › Research

    27. Published

      Exploring the chemical space for freeze-drying excipients

      Meng-Lund, H., Holm, T. P., Poso, A., Jørgensen, Lene, Rantanen, Jukka & Grohganz, Holger, 2019, In: International Journal of Pharmaceutics. 566, p. 254-263 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Factors of importance for a successful delivery system for proteins

      van de Weert, Marco, Jørgensen, Lene, Horn Moeller, E. & Frøkjær, Sven, Nov 2005, In: Expert Opinion on Drug Delivery. 2, 6, p. 1029-37 9 p.

      Research output: Contribution to journal › Review › Research › peer-review

    29. Published

      Fluorophore labeling of a cell-penetrating peptide significantly alters the mode and degree of biomembrane interaction

      Hedegaard, S. F., Derbas, M. S., Lind, T. K., Kasimova, M. R., Christensen, M. V., Michaelsen, M. H., Campbell, R. A., Jørgensen, Lene, Franzyk, Henrik, Cárdenas, M. & Nielsen, Hanne Mørck, 2018, In: Scientific Reports. 8, 1, 14 p., 6327.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Formation of dielectric layers and charge regulation in protein adsorption at biomimetic interfaces

      Hartvig, R. A., van de Weert, Marco, Østergaard, Jesper, Jørgensen, Lene & Jensen, H., 2012, In: Langmuir. 28, 3, p. 1804-1815

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Formulation technologies to overcome unfavorable properties of peptides and proteins for pulmonary delivery

      Wan, F., Møller, E. H., Yang, Mingshi & Jørgensen, Lene, 2012, In: Drug Discovery Today: Technologies. 9, 2, p. e141-e146

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      In vitro release of insulin aspart incorporated into water-in-oil emulsions

      Jørgensen, Lene, Vermehren, Charlotte, Bjerregaard, S. & Frøkjær, Sven, 2004, In: Journal of Drug Delivery Science and Technology. 14, 6, p. 455-459

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Incorporation of a synthetic mycobacterial monomycoloyl glycerol analogue stabilizes dimethyldioctadecylammonium liposomes and potentiates their adjuvant effect in vivo

      Nordly, P. J., Korsholm, K. S., Pedersen, E. A., Khilji, T. S., Franzyk, Henrik, Jørgensen, Lene, Nielsen, Hanne Mørck, Agger, E. M. & Foged, Camilla, 2011, In: European Journal of Pharmaceutics and Biopharmaceutics. 77, 1, p. 89-98

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Influence of PEGylation with linear and branched PEG chains on the adsorption of glucagon to hydrophobic surfaces

      Pinholt, C., Bukrinsky, J. T., Hostrup, S., Frøkjær, Sven, Norde, W. & Jørgensen, Lene, 2011, In: European Journal of Pharmaceutics and Biopharmaceutics. 77, 1, p. 139-147

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Influence of acylation on the adsorption of GLP-2 to hydrophobic surfaces

      Pinholt, C., Kapp, S. J., Bukrinsky, J. T., Hostrup, S., Frøkjær, Sven, Norde, W. & Jørgensen, Lene, 2013, In: International Journal of Pharmaceutics. 440, 1, p. 63-71 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Influence of acylation on the adsorption of insulin to hydrophobic surfaces

      Pinholt, C., Hostrup, S., Bukrinsky, J. T., Frøkjær, Sven & Jørgensen, Lene, 2011, In: Pharmaceutical Research. 28, p. 1031-1040

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Influence of glycosylation on the adsorption of Thermomyces lannuginosus lipase to hydrophobic and hydrophilic surfaces

      Pinholt, C., Fanø, M., Wiberg, C., Hostrup, S., Bukrinsky, J. T., Frøkjær, Sven, Norde, W. & Jørgensen, Lene, 2010, In: European Journal of Pharmaceutical Sciences. 40, 4, p. 273-281

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Infrared spectroscopy of protein pharmaceuticals

      van de Weert, Marco & Jørgensen, Lene, 2009, Advances in Biomedical Spectroscopy: Biological and Biomedical Infrared Spectrocopy. Barth, A. & Haris, P. I. (eds.). Amsterdam: IOS Press, Vol. 2. p. 168-177

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication

    39. Published

      Infrared spectroscopy to characterize protein aggregates

      van de Weert, Marco & Jørgensen, Lene, 2012, Analysis of aggregates and particles in protein pharmaceuticals. Mahler, H-C. & Jiskoot, W. (eds.). Hoboken: Wiley, p. 227-248

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    40. Published

      Interaction of peptidomimetics with bilayer membranes: biophysical characterization and cellular uptake

      Jing, X., Kasimova, M. R., Simonsen, A. H., Jørgensen, Lene, Malmsten, M., Franzyk, Henrik & Foged, Camilla, 2012, In: Langmuir. 28, 11, p. 5167-5175

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Interfacial adsorption of insulin - conformational changes and reversibility of adsorption

      Mollmann, S. H., Jørgensen, Lene, Bukrinsky, J. T., Elofsson, U., Norde, W. & Frøkjær, Sven, 2006, In: European Journal of Pharmaceutical Sciences. 27, 2-3, p. 194-204

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Interfacial complexes between a protein and lipophilic ions at an oil - water interface

      Hartvig, R. A., Méndez, M. A., van de Weert, Marco, Jørgensen, Lene, Østergaard, Jesper, Girault, H. H. & Jensen, H., 2010, In: Analytical Chemistry. 82, 18, p. 7699-7705

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Investigation on Secondary Structure Perturbations of Proteins Embedded in Solid Lipid Matrices as a Novel Indicator of their Biological Activity upon In Vitro Release

      Zeeshan, F., Tabbassum, M., Jørgensen, Lene & Medlicott, N. J., 1 Feb 2018, In: AAPS PharmSciTech. 19, 2, p. 769–782

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Issues in Development of Biodrug Delivery Systems

      Jørgensen, Lene, Frøkjær, Sven & Nielsen, Hanne Mørck, 2010, Biodrug Delivery Systems: Fundamentals, Applications and Clinical Development. Morishita, M. & Park, K. (eds.). 1 ed. Informa Healthcare, p. 13-25

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    45. Published

      Issues in development of biodrug delivery systems

      Jørgensen, Lene, Frøkjær, Sven & Nielsen, Hanne Mørck, 2010, Biodrug delivery systems: fundamentals, applications and clinical development. Morishita, M. & Park, K. (eds.). New York: Informa Healthcare, p. 13-25

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    46. Published

      Karakterisering af lægemiddelstof-liposom-vekselvirkninger i et kapillar

      Østergaard, Jesper, Franzen, U., Møller, E. H., Jørgensen, Lene, Larsen, C. S. & Jensen, H., 2008, In: Dansk Kemi. 89, 8, p. 27-29

      Research output: Contribution to journal › Journal article › Research

    47. Published

      Kinetics of insulin adsorption and gelation at the oil-water interface monitored using fluorescence correlation spectroscopy

      Donsmark, J., Jørgensen, Lene, Mollmann, S. H., Frøkjær, Sven & Rischel, C., 2006, In: Pharmaceutical Research. 23, 1, p. 148-155

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Kinetics of insulin adsorption at the oil-water interface and diffusion properties of adsorbed layers monitored using fluorescence correlation spectroscopy

      Donsmark, J., Jørgensen, Lene, Mollmann, S., Frøkjær, Sven & Rischel, C., 1 Jan 2006, In: Pharmaceutical Research. 23, 1, p. 148-155 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Lipid based drug delivery systems for proteins: Physical stability of proteins at the oil-water interface

      Jørgensen, Lene, 2009, VDM Verlag Dr. Müller Aktiengesellschaft & C o. KG.

      Research output: Book/Report › Book › Research › peer-review

    50. Published

      Lipidation effect on surface adsorption and associated fibrillation of the model protein insulin

      Hedegaard, S. C. F., Cardenas Gomez, M., Barker, R., Jørgensen, Lene & van de Weert, Marco, 2016, In: Langmuir. 32, 28, p. 7241–7249 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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