Lene Jørgensen

Lene Jørgensen

Associate Professor

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    1. Published

      Design and processing of nanogels as delivery systems for peptides and proteins: Therapeutic Delivery

      Arnfast, L., Madsen, C. G., Jørgensen, Lene & Baldursdottir, S., 1 Jun 2014, In: Therapeutic Delivery. 5, 6, p. 691-708 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Screening of formulation parameters for stabilizing recombinant human serum albumin (rHSA) in liquid formulations

      Baldursdottir, S., Tauhaybeche, M., Pekka Pajander, J., Bukrinski, J. T. & Jørgensen, Lene, Aug 2016, In: Journal of Drug Delivery Science and Technology. 34, p. 1-9 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Rheological Characterization of Lysozyme Adsorption to Oil-Water Interface Using Double Wall Ring Geometry

      Baldursdottir, S. G. & Jørgensen, Lene, 2012.

      Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

    4. Published

      Comparison of two methods detecting lysozyme adsorption to oil-water interface in the presence of surfactants

      Baldursdottir, S. G. & Jørgensen, Lene, 2012. 1 p.

      Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

    5. Published

       Adsorption of proteins at the oil/water inerface - observation of protein adsorption by interfacial shear stress measurements

      Baldursdóttir, S. G., Fullerton, M. S., Nielsen, S. H. & Jørgensen, Lene, 2010, In: Colloids and Surfaces B: Biointerfaces. 79, p. 41-46

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Proteiner i lægemidler - de sætter sig alle de forkerte steder

      Baldursdóttir, S. G., Nielsen, S. H., Fullerton, M. & Jørgensen, Lene, 2010, In: Lægemiddelforskning. 2010, p. 43-45

      Research output: Contribution to journal › Journal article › Research

    7. Published

      The influence of size, structure and hydrophilicity of model surfactants on the adsorption of lysozyme to oil-water interface-Interacial shear measurements

      Baldursdóttir, S. G. & Jørgensen, Lene, 2011, In: Colloids and Surfaces B: Biointerfaces. 87, p. 96-102

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Surface area, volume and shape descriptors as a novel tool for polymer lead design and discovery

      Christensen, J. R., Meng-Lund, H., Grohganz, Holger, Poso, A., Laitinen, T., Korhonen, O., Jørgensen, Lene & Pajander, J., 1 May 2017, In: European Journal of Pharmaceutical Sciences. 102, p. 188-195 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      pH dependent polymer surfactants for hindering BSA adsorption to oil-water interface

      Colak, S., Guzman, P., Medlicott, N., Tehnu, H., Niskanen , J., Alhoranta, A., Jørgensen, Lene & Baldursdottir, S. G., 2013, In: Nordic Rheology Society Annual Transactions. 21, p. 329-334

      Research output: Contribution to journal › Conference article › Research

    10. Published

      Kinetics of insulin adsorption at the oil-water interface and diffusion properties of adsorbed layers monitored using fluorescence correlation spectroscopy

      Donsmark, J., Jørgensen, Lene, Mollmann, S., Frøkjær, Sven & Rischel, C., 1 Jan 2006, In: Pharmaceutical Research. 23, 1, p. 148-155 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Kinetics of insulin adsorption and gelation at the oil-water interface monitored using fluorescence correlation spectroscopy

      Donsmark, J., Jørgensen, Lene, Mollmann, S. H., Frøkjær, Sven & Rischel, C., 2006, In: Pharmaceutical Research. 23, 1, p. 148-155

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Liposomer i lægemiddelforskning

      Franzen, U., Jørgensen, Lene, Larsen, C. S., Jensen, H. & Østergaard, Jesper, 2007, In: Lægemiddelforskning. p. 14-15

      Research output: Contribution to journal › Journal article › Communication

    13. Published

      Determination of liposome-buffer distribution coefficients of charged drugs by capillary electrophoresis frontal analysis

      Franzen, U., Jørgensen, Lene, Larsen, C. S., Heegaard, N. H. H. & Østergaard, Jesper, 2009, In: Electrophoresis. 30, 15, p. 2711-2719

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Multivariate analysis of protein physical stability

      Guzman, P., Jørgensen, Lene, Strachan, C., Rades, T. & Medlicott, N., 2010.

      Research output: Contribution to conference › Conference abstract for conference › Research

    15. Published

      Elucidating the mechanisms of protein antigen adsorption to the CAF/NAF liposomal vaccine adjuvant systems: Effect of charge, fluidity and antigen-to-lipid ratio

      Hamborg, M., Rose, F., Jørgensen, Lene, Bjorklund, K., Pedersen, H., Christensen, D. & Foged, Camilla, 25 Apr 2014, In: BBA General Subjects. 1838, 8, p. 2001-2010 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Protein antigen adsorption to the DDA/TDB liposomal adjuvant: effect on protein structure, stability, and liposome physicochemical characteristics

      Hamborg, M., Jørgensen, Lene, Bojsen, A. R., Christensen, D. & Foged, Camilla, 2013, In: Pharmaceutical Research. 30, 1, p. 140-55 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      The physical stability of the recombinant tuberculosis fusion antigens h1 and h56

      Hamborg, M., Kramer, R., Schanté, C. E., Agger, E. M., Christensen, D., Jørgensen, Lene, Foged, Camilla & Middaugh, C. R., Oct 2013, In: Journal of Pharmaceutical Sciences. 102, 10, p. 3567-78 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Protein adsorption at charged surfaces: the role of electrostatic interactions and interfacial charge regulation

      Hartvig, R. A., van de Weert, Marco, Østergaard, Jesper, Jørgensen, Lene & Jensen, Henrik Elvang, 15 Mar 2011, In: Langmuir. 27, 6, p. 2634-2643 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Formation of dielectric layers and charge regulation in protein adsorption at biomimetic interfaces

      Hartvig, R. A., van de Weert, Marco, Østergaard, Jesper, Jørgensen, Lene & Jensen, H., 2012, In: Langmuir. 28, 3, p. 1804-1815

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Interfacial complexes between a protein and lipophilic ions at an oil - water interface

      Hartvig, R. A., Méndez, M. A., van de Weert, Marco, Jørgensen, Lene, Østergaard, Jesper, Girault, H. H. & Jensen, H., 2010, In: Analytical Chemistry. 82, 18, p. 7699-7705

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Protein adsorption at charged surfaces: The role of electrostatic interactions and interacial charge regulation

      Hartvig, R. A., van de Weert, Marco, Østergaard, Jesper, Jørgensen, Lene & Jensen, H., 2011, In: Langmuir. 27, p. 2634-2643

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Lipidation effect on surface adsorption and associated fibrillation of the model protein insulin

      Hedegaard, S. C. F., Cardenas Gomez, M., Barker, R., Jørgensen, Lene & van de Weert, Marco, 2016, In: Langmuir. 32, 28, p. 7241–7249 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Fluorophore labeling of a cell-penetrating peptide significantly alters the mode and degree of biomembrane interaction

      Hedegaard, S. F., Derbas, M. S., Lind, T. K., Kasimova, M. R., Christensen, M. V., Michaelsen, M. H., Campbell, R. A., Jørgensen, Lene, Franzyk, Henrik, Cárdenas, M. & Nielsen, Hanne Mørck, 2018, In: Scientific Reports. 8, 1, 14 p., 6327.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Screening of novel excipients for freeze-dried protein formulations

      Holm, T. P., Meng-Lund, H., Rantanen, Jukka, Jørgensen, Lene & Grohganz, Holger, 2021, In: European Journal of Pharmaceutics and Biopharmaceutics. 160, p. 55-64 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Interaction of peptidomimetics with bilayer membranes: biophysical characterization and cellular uptake

      Jing, X., Kasimova, M. R., Simonsen, A. H., Jørgensen, Lene, Malmsten, M., Franzyk, Henrik & Foged, Camilla, 2012, In: Langmuir. 28, 11, p. 5167-5175

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Membrane adsorption and binding, cellular uptake and cytotoxicity of cell-penetrating peptidomimetics with α-peptide/β-peptoid backbone: effects of hydrogen bonding and α-chirality in the β-peptoid residues

      Jing, X., Yang, M., Kasimova, M. R., Malmsten, M., Franzyk, Henrik, Jørgensen, Lene, Foged, Camilla & Nielsen, Hanne Mørck, 2012, In: BBA General Subjects. 1818, 11, p. 2660-2668 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      The challenges in and importance of analysing protein structure and physical stability in complex formulations

      Jørgensen, Lene, Jensen, M. G., Roest, N., Pinholt, C. & van de Weert, Marco, 1 Jul 2013, In: Journal of Drug Delivery Science and Technology. 23, 4, p. 347-353 7 p.

      Research output: Contribution to journal › Review › Research › peer-review

    28. Published

      Probing structural changes of proteins incorporated into water-in-oil emulsions

      Jørgensen, Lene, van de Weert, Marco, Vermehren, C., Bjerregaard, S. & Frøkjær, Sven, Jul 2004, In: Journal of Pharmaceutical Sciences. 93, 7, p. 1847-59 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Protein adsorption and displacement at lipid layers determined by total internal reflection fluorescence  (TIRF)

      Jørgensen, Lene, Krøyer Wood, G., Rosenkrands, I., Petersen, C. & Christensen, D., 2009, In: Journal of Liposome Research. 19, 2, p. 99-104

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Adsorption of insulin with varying self-association profiles to a solid Teflon surface-Influence on protein structures, fibrillation tendency and thermal stability

      Jørgensen, Lene, Bennedsen, P., Hoffmann, S. V., Pinholt, C., Krogh, R. L., Jensen, M. G., Hostrup, S. & Burkinksky, J. T., 2011, In: European Journal of Pharmaceutical Sciences. 42, 5, p. 509-516

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Issues in development of biodrug delivery systems

      Jørgensen, Lene, Frøkjær, Sven & Nielsen, Hanne Mørck, 2010, Biodrug delivery systems: fundamentals, applications and clinical development. Morishita, M. & Park, K. (eds.). New York: Informa Healthcare, p. 13-25

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    32. Published

      In vitro release of insulin aspart incorporated into water-in-oil emulsions

      Jørgensen, Lene, Vermehren, Charlotte, Bjerregaard, S. & Frøkjær, Sven, 2004, In: Journal of Drug Delivery Science and Technology. 14, 6, p. 455-459

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Biotechnology-based pharmaceuticals

      Jørgensen, Lene, Nielsen, Hanne Mørck & Frøkjær, Sven, 2009, Modern pharmaceutics: applications and advances. Florence, A. T. & Siepmann, J. (eds.). 5 ed. New York: Informa Healthcare, Vol. 2. p. 259-293 (Drugs and the Pharmaceutical Sciences, Vol. 188).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    34. Published

      Secondary structure alteration in insulin and growth hormone water-in-oil emulsions

      Jørgensen, Lene, Vermehren, Charlotte, Bjerregaard, S. & Frøkjær, Sven, 2003, In: Internation Journal of Pharmaceutics. 254, 1, p. 7-10

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Micropipette manipulation a technique to evaluate the stability of water-in-oil emulsions containing proteins

      Jørgensen, Lene, Kim, D. H., Vermehren, Charlotte, Bjerregaard, S. & Frøkjær, Sven, 2004, In: Journal of Pharmaceutical Sciences. 93, 12, p. 2994-3003

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Issues in Development of Biodrug Delivery Systems

      Jørgensen, Lene, Frøkjær, Sven & Nielsen, Hanne Mørck, 2010, Biodrug Delivery Systems: Fundamentals, Applications and Clinical Development. Morishita, M. & Park, K. (eds.). 1 ed. Informa Healthcare, p. 13-25

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    37. Published

      Delivery technologies for biopharmaceuticals: Peptides, proteins, nucleic acids and vaccines

      Jørgensen, Lene & Nielsen, Hanne Mørck, 2009, Wiley. 413 p.

      Research output: Book/Report › Book › Research › peer-review

    38. Published

      Lipid based drug delivery systems for proteins: Physical stability of proteins at the oil-water interface

      Jørgensen, Lene, 2009, VDM Verlag Dr. Müller Aktiengesellschaft & C o. KG.

      Research output: Book/Report › Book › Research › peer-review

    39. Published

      Analysis of protein physical stability in lipid based delivery systems: the challenges of lipid drug delivery systems

      Jørgensen, Lene, Martins, S. & van de Weert, Marco, 2009, In: Journal of Biomedical Nanotechnology. 5, 4, p. 401-408

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Recent trends in stabilising peptides and proteins in pharmaceutical formulation - considerations in the choice of excipients

      Jørgensen, Lene, Hostrup, S., Møller, E. H. & Grohganz, Holger, 2009, In: Expert Opinion on Drug Delivery. 6, 11, p. 1219-1230

      Research output: Contribution to journal › Review › Research

    41. Published

      Competitive adsorption of monoclonal antibodies and nonionic surfactants at solid hydrophobic surfaces

      Kapp, S. J., Larsson, I., van de Weert, Marco, Cardenas Gomez, M. & Jørgensen, Lene, 2015, In: Journal of Pharmaceutical Sciences. 104, 2, p. 593-601 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Erratum: Kapp SJ, Larsson I, Van De Weert M, Ćardenas M, Jorgensen L. 2015. Competitive Adsorption of Monoclonal Antibodies and Nonionic Surfactants at Solid Hydrophobic Surfaces. 2015. J Pharm Sci 104:593-601

      Kapp, S. J., Larsson, I., van de Weert, Marco, Ćardenas, M. & Jørgensen, Lene, 2015, In: Journal of Pharmaceutical Sciences. 104, 10, p. 3587 1 p.

      Research output: Contribution to journal › Comment/debate › Research

    43. Published

      Calcipotriol delivery into the skin with PEGylated liposomes

      Knudsen, N. Ø., Rønholt, Stine, Salte, R. D., Jørgensen, Lene, Thormann, T., Basse, L. H., Hansen, J., Frøkjær, Sven & Foged, Camilla, 2012, In: European Journal of Pharmaceutics and Biopharmaceutics. 81, 3, p. 532-9 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Design of cyclic RKKH peptide-conjugated PEG liposomes targeting the integrin a2ß1 receptor

      Knudsen, N. Ø., Schiffelers, R. M., Jørgensen, Lene, Hansen, J., Frøkjær, Sven & Foged, Camilla, 2012, In: International Journal of Pharmaceutics. 428, 1-2, p. 171-177

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Targeting of liposome-associated calcipotriol to the skin: effect of liposomal membrane fluidity and skin barrier integrity

      Knudsen, N. Ø., Jørgensen, Lene, Hansen, J., Vermehren, C., Frøkjær, Sven & Foged, Camilla, 2011, In: International Journal of Pharmaceutics. 416, p. 478-485

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Penetration of gel and liquid state liposomes into barrier-impaired skin

      Knudsen, N. Ø., Frøkjær, Sven, Hansen, J., Jørgensen, Lene & Foged, Camilla, 2010, In: Journal of Pharmacy and Pharmacology. p. 793

      Research output: Contribution to journal › Conference article › Research › peer-review

    47. Published

      Screening of plants used in the European traditional medicine to treat memory disorders for acetylcholinesterase inhibitory activity and anti amyloidogenic activity

      Lobbens, E. S. B., Vissing, K. J., Jørgensen, Lene, van de Weert, Marco & Jäger, A. K., 22 Mar 2017, In: Journal of Ethnopharmacology. 200, p. 66-73 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Mechanistic study of the inhibitory activity of Geum urbanum extract against α-Synuclein fibrillation

      Lobbens, E. S., Breydo, L., Pedersen, T. S., Vestergaard, Bente, Jäger, A. K., Jørgensen, Lene, Uversky, V. & van de Weert, Marco, 21 Jun 2016, In: B B A - Proteins and Proteomics. 1864, 9, p. 1160-1169 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      The Inhibitory Effect of Natural Products on Protein Fibrillation May Be Caused by Degradation Products – A Study Using Aloin and Insulin

      Lobbens, E. S., Foderà, Vito, Nyberg, N., Andersen, K., Jäger, A. K., Jørgensen, Lene & van de Weert, Marco, 16 Feb 2016, In: PloS one. 11, 2, p. 1-16 16 p., e0149148.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Correlation between enzyme activity an stability of a protease, an alpha-amaylase and a lipase in a simplified liquid laundry detergent system, determined by differential scanning calorimetry

      Lund, H., Kaasgaard, S. G., Skagerlind, P., Jørgensen, Lene, Jørgensen, C. I. & van de Weert, Marco, 2012, In: Journal of Surfactants and Detergents. 15, p. 9-21

      Research output: Contribution to journal › Journal article › Research › peer-review

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