Protein antigen adsorption to the DDA/TDB liposomal adjuvant: effect on protein structure, stability, and liposome physicochemical characteristics
Research output: Contribution to journal › Journal article › Research › peer-review
Understanding the nature of adjuvant-antigen interactions is important for the future design of efficient and safe subunit vaccines, but remains an analytical challenge. We studied the interactions between three model protein antigens and the clinically tested cationic liposomal adjuvant composed of dimethyldioctadecylammonium (DDA) and trehalose 6,6'-dibehenate (TDB).
Original language | English |
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Journal | Pharmaceutical Research |
Volume | 30 |
Issue number | 1 |
Pages (from-to) | 140-55 |
Number of pages | 16 |
ISSN | 0724-8741 |
DOIs | |
Publication status | Published - 2013 |
ID: 43971760