Birger Brodin Larsen
Professor
CNS Drug Delivery and Barrier Modelling
Universitetsparken 2
2100 København Ø
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Precapillary sphincters and pericytes at first-order capillaries as key regulators for brain capillary perfusion
Zambach, S. A., Cai, Changsi, Helms, H. C. C., Hald, B. O., Dong, Y., Fordsmann, J. C., Nielsen, R. M., Hu, J., wbh615, wbh615, Larsen, Birger Brodin & Lauritzen, Martin, 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 26, e2023749118.Research output: Contribution to journal › Journal article › Research › peer-review
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miRNA-27a-3p and miRNA-222-3p as Novel Modulators of Phosphodiesterase 3a (PDE3A) in Cerebral Microvascular Endothelial Cells
Yasmeen, S., Kaur, S., Mirza, A. H., Larsen, Birger Brodin, Pociot, Flemming & Kruuse, Christina Rostrup, Aug 2019, In: Molecular Neurobiology. 56, 8, p. 5304–5314Research output: Contribution to journal › Journal article › Research › peer-review
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In Vitro Blood-Brain Barrier Models-An Overview of Established Models and New Microfluidic Approaches
Wolff, A., Antfolk, M., Larsen, Birger Brodin & Tenje, M., 28 Jan 2015, In: Journal of Pharmaceutical Sciences. 104, 9, p. 2727-2746 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Carbonic anhydrase imhibitors. Transepithelial transport of novel anticancer sulfonamide inhibitors of the cancer-associated isozyme CA IX is dependent on the p.gp efflux transporter
Vullo, D., Steffansen, B., Larsen, Birger Brodin, Supuran, C. T., Scozzafava, A. & Nielsen, C. U., 2006, In: Bioorganic & Medicinal Chemistry Letters. 14, 7, p. 2418-2427Research output: Contribution to journal › Journal article › Research › peer-review
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Transendothelial electrical resistance measurement across the blood–brain barrier: A critical review of methods
Vigh, J. P., Kincses, A., Ozgür, Burak, Walter, F. R., Santa-Maria, A. R., Valkai, S., Vastag, M., Neuhaus, W., Larsen, Birger Brodin, Dér, A. & Deli, M. A., 2021, In: Micromachines. 12, 6, 18 p., 685.Research output: Contribution to journal › Review › Research › peer-review
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Sortilin regulates blood-brain barrier integrity
Toth, A. E., Helms, H. C., Harazin, A., Johnsen, K. B., Goldeman, C., Burkhart, A., Thomsen, M. S., Kempen, P. J., Klepe, A., Lipka, D. V., Møller, P. L., Andresen, T. L., Nyegaard, M., Moos, T., Larsen, Birger Brodin & Nielsen, M. S., 2022, In: The FEBS Journal. 289, 4, p. 1062-1079Research output: Contribution to journal › Journal article › Research › peer-review
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Stroke and Drug Delivery--In Vitro Models of the Ischemic Blood-Brain Barrier
Tornabene, E. & Larsen, Birger Brodin, Feb 2016, In: Journal of Pharmaceutical Sciences. 105, 2, p. 398-405 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of oxygen-glucose deprivation (OGD) on barrier properties and mRNA transcript levels of selected marker proteins in brain endothelial cells/astrocyte co-cultures
Tornabene, E., Helms, H. C. C., Pedersen, Stine Helene Falsig & Larsen, Birger Brodin, 2019, In: PLoS ONE. 14, 8, 20 p., e0221103.Research output: Contribution to journal › Journal article › Research › peer-review
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Prodrugs of purine and pyrimidine analogues for the intestinal di/tri-peptide transporter PepT1: affinity for hPepT1 in Caco-2 cells, drug release in aqueous media and in vitro metabolism
Thomsen, A. E., Friedrichsen, G. M., Sørensen, A. H., Andersen, R., Nielsen, C. U., Larsen, Birger Brodin, Begtrup, M., Frøkjær, Sven & Steffansen, B., 2003, In: Journal of Controlled Release. 86, 2-3, p. 279-92 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Erratum: Prodrugs of purine and pyrimidine analogues for the intestinal di/tri-peptide transporter PepT1: Affinity for hPepT1 in Caco-2 cells, drug release in aqueous media and in vitro metabolism (Journal of Controlled Release (2003) 86 (279-292) PII: S0168365902004133)
Thomsen, A. E., Friedrichsen, G. M., Sørensen, A. H., Andersen, R., Nielsen, C. U., Larsen, Birger Brodin, Begtrup, M., Frøkjær, Sven & Steffansen, B., 7 Mar 2003, In: Journal of Controlled Release. 88, 2Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification and Characterization of a Novel Nontranslated Sequence Variant of the Human Intestinal Di-/Tripeptide Transporter, hPEPT1
Søndergaard, H. B., Nielsen, C. U. & Larsen, Birger Brodin, 31 Dec 2012, In: International Journal of Peptides. 2012, 2012, 7 p., 743472.Research output: Contribution to journal › Journal article › Research › peer-review
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hPEPT1 is responsible for uptake and transport of Gly-Sar in the human bronchial airway epithelial cell-line Calu-3
Søndergaard, H. B., Larsen, Birger Brodin & Nielsen, C. U., 2008, In: Pflügers Archiv: European Journal of Physiology. 456, 3, p. 611-622Research output: Contribution to journal › Journal article › Research › peer-review
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Cloning of the pig PEPT2 (pPEPT2) and characterization of the effects of epidermal growth factor (EGF) on pPEPT2-mediated peptide uptake in the renal porcine cell line LLC-PK1
Søndergaard, H. B., Bravo, S. A., Nielsen, C. U., Frøkjær, Sven & Larsen, Birger Brodin, 2008, In: European Journal of Pharmaceutical Sciences. 33, 4-5, p. 332-342Research output: Contribution to journal › Journal article › Research › peer-review
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The putative proton-coupled organic cation antiporter is involved in uptake of triptans into human brain capillary endothelial cells
Svane, Nana Isabella, Pedersen, Alberte Bay Villekjær, Rodenberg, A., Ozgür, Burak, Saaby, Lasse, Bundgaard, C., Kristensen, Mie, Tfelt-Hansen, P. & Larsen, Birger Brodin, 2024, In: Fluids and Barriers of the CNS. 21, 19 p., 39.Research output: Contribution to journal › Journal article › Research › peer-review
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Calu-3 cells grown under AIC and LCC conditions: implications for dipeptide uptake and transepithelial transport of substances
Stentebjerg-Andersen, A., Notlevesen, I. V., Larsen, Birger Brodin & Nielsen, C. U., 2011, In: European Journal of Pharmaceutics and Biopharmaceutics. 78, 1, p. 19-26Research output: Contribution to journal › Journal article › Research › peer-review
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Intestinal solute carriers: an overview of trends and strategies for improving oral drug absorption
Steffansen, B., Nielsen, C. U., Larsen, Birger Brodin, Eriksson, A. H., Andersen, R. & Frøkjær, Sven, 2004, In: European Journal of Pharmaceutical Sciences. 21, 1, p. 3-16 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Serotonin transporter protein (SERT) and P-glycoprotein (P-gp) binding activity of montanine and coccinine from three species of Haemanthus L. (Amaryllidaceae)
Stafford, G. I., Birer, C., Larsen, Birger Brodin, Christensen, Søren Brøgger, Eriksson, A. H., Jäger, A. & Rønsted, Nina, Sep 2013, In: South African Journal of Botany. 88, p. 101-106 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Bidirectional apical-basal traffic of the cation-independent mannose-6-phosphate receptor in brain endothelial cells
Siupka, P., Hersom, M. N., Lykke-Hartmann, K., Johnsen, K. B., Thomsen, L. B., Andresen, T. L., Moos, T., Abbott, N. J. & Larsen, Birger Brodin, 1 Jan 2017, In: Journal of Cerebral Blood Flow and Metabolism. 37, 7, p. 2598-2613Research output: Contribution to journal › Journal article › Research › peer-review
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The putative P-gp inhibitor telmisartan does not affect the transcellular permeability and cellular uptake of the calcium channel antagonist verapamil in the P-glycoprotein expressing cell line MDCK II MDR1
Saaby, Lasse, Tfelt-Hansen, P. & Larsen, Birger Brodin, 11 Jun 2015, In: Pharmacology Research & Perspectives. 3, 4, p. 1-9 9 p., e00151.Research output: Contribution to journal › Journal article › Research › peer-review
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A Critical View on In Vitro Analysis of P-glycoprotein (P-gp) Transport Kinetics
Saaby, Lasse & Larsen, Birger Brodin, Sep 2017, In: Journal of Pharmaceutical Sciences. 106, 9, p. 2257-2264 8 p.Research output: Contribution to journal › Review › Research › peer-review
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IPEC-J2 rMdr1a, a New Cell Line with Functional Expression of Rat P-glycoprotein Encoded by Rat Mdr1a for Drug Screening Purposes
Saaby, Lasse, Trasborg, J., Rasmussen, M. A., Holst, B. & Larsen, Birger Brodin, 17 Jul 2020, In: Pharmaceutics. 12, 7, 17 p., 673.Research output: Contribution to journal › Journal article › Research › peer-review
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Current status of rational design of prodrugs targeting the intestinal di/tri-peptide transporter hPEPT1 (SLC15A1)
Saaby, Lasse, Nielsen, C. U., Steffansen, B., Larsen, Birger Brodin & Larsen, S. B. L., 2013, In: Journal of Drug Delivery Science and Technology. 23, 4, p. 307–314Research output: Contribution to journal › Journal article › Research › peer-review
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IPEC-J2 MDR1, a Novel High-Resistance Cell Line with Functional Expression of Human P-glycoprotein (ABCB1) for Drug Screening Studies
Saaby, Lasse, Helms, H. C. C. & Larsen, Birger Brodin, 1 Feb 2016, In: Molecular Pharmaceutics. 13, 2, p. 640-52 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Prostaglandin E2 release from the dermis regulates sodium permeability of frog skin epithelium
Rytved, K. A., Larsen, Birger Brodin & Nielsen, R., 1995, In: Acta Physiologica Scandinavica. 153, p. 263-270Research output: Contribution to journal › Journal article › Research › peer-review
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Prostaglandin E2 release from dermis regulates sodium permeability of frog skin epithelium
RYTVED, K. A., Larsen, Birger Brodin & NIELSEN, R., 1 Jan 1995, In: Acta Physiologica Scandinavica. 153, 3, p. 263-270 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Screening novel CNS drug candidates for P-glycoprotein interactions using the cell line iP-gp: In vitro efflux ratios from iP-gp and MDCK-MDR1 monolayers compared to brain distribution data from mice
Ozgür, Burak, Saaby, Lasse, Janfelt, Christian, Langthaler, K., Eneberg, E., Jacobsen, A., Badolo, L., Montanari, D. & Larsen, Birger Brodin, 2021, In: European Journal of Pharmaceutics and Biopharmaceutics. 169, p. 211-219Research output: Contribution to journal › Journal article › Research › peer-review
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Hypoxia increases expression of selected blood–brain barrier transporters GLUT-1, P-gp, SLC7A5 and TFRC, while maintaining barrier integrity, in brain capillary endothelial monolayers
Ozgür, Burak, Helms, H. C. C., Tornabene, E. & Larsen, Birger Brodin, 2022, In: Fluids and Barriers of the CNS. 19, 1, 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Data demonstrating the challenges of determining the kinetic parameters of P-gp mediated transport of low-water soluble substrates
Ozgür, Burak, Saaby, Lasse, Langthaler, K. & Larsen, Birger Brodin, 2018, In: Data in Brief. 16, p. 655-659 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of the IPEC-J2 MDR1 (iP-gp) cell line as a tool for identification of P-gp substrates
Ozgür, Burak, Saaby, Lasse, Langthaler, K. & Larsen, Birger Brodin, 2018, In: European Journal of Pharmaceutical Sciences. 112, p. 112-121 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of an iPSC-based barrier model for blood-brain barrier investigations using the SBAD0201 stem cell line
Ozgür, Burak, Puris, E., Brachner, A., Appelt-Menzel, A., Oerter, S., Balzer, V., Holst, M. R., Christiansen, R. F., Hyldig, K., Buckley, S. T., Kristensen, Mie, Auriola, S., Jensen, A., Fricker, G., Nielsen, M. S., Neuhaus, W. & Larsen, Birger Brodin, 2023, In: Fluids and Barriers of the CNS. 20, 1, 15 p., 96.Research output: Contribution to journal › Journal article › Research › peer-review
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Affinity and translocation relationships via hPEPT1 of H-Xaa-Ser-OH dipeptides: evaluation of H-Phe-Ser-OH as a pro-moiety for ibuprofen and benzoic acid prodrugs
Omkvist, D. H., Trangbæk, D. J., Mildon, J., Paine, J. S., Larsen, Birger Brodin, Begtrup, M. & Nielsen, C. U., 2011, In: European Journal of Pharmaceutics and Biopharmaceutics. 77, 2, p. 327-331Research output: Contribution to journal › Journal article › Research › peer-review
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Ibuprofen is a non-competitive inhibitor of the peptide transporter hPEPT1 (SLC15A1): possible interactions between hPEPT1 substrates and ibuprofen
Omkvist, D. H., Larsen, Birger Brodin & Nielsen, C. U., 2010, In: British Journal of Pharmacology. 161, 8, p. 1793-1805Research output: Contribution to journal › Journal article › Research › peer-review
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A quantitative structure-activity relationship for translocation of tripeptides via the human proton-coupled peptide transporter, hPEPT1 (SLC15A1)
Omkvist, D. H., Larsen, S. B., Nielsen, C. U., Steffansen, B., Olsen, L., Jørgensen, Flemming Steen & Larsen, Birger Brodin, 2010, In: The AAPS Journal. 12, 3, p. 385-396Research output: Contribution to journal › Journal article › Research › peer-review
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The absorptive flux of the anti-epileptic drug substance vigabatrin is carrier-mediated across Caco-2 cell monolayers
Nøhr, M. K., Hansen, S. H., Larsen, Birger Brodin, Holm, R. & Nielsen, C. U., 23 Jan 2014, In: European Journal of Pharmaceutical Sciences. 51, p. 1-10Research output: Contribution to journal › Journal article › Research › peer-review
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Apicobasal transferrin receptor localization and trafficking in brain capillary endothelial cells
Nielsen, S. S. E., Holst, M. R., Langthaler, Kristine, Bruun, E. H., Larsen, Birger Brodin & Nielsen, M. S., 2023, In: Fluids and Barriers of the CNS. 20, 1, 15 p., 2.Research output: Contribution to journal › Journal article › Research › peer-review
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Transport characteristics of L-carnosine and the anticancer derivative 4-toluenesulfonylureido-carnosine in a human epithelial cell line
Nielsen, C. U., Supuran, C. T., Scozzafava, A., Frøkjær, Sven, Steffansen, B. & Larsen, Birger Brodin, 2002, In: Pharmaceutical Research. 19, 9, p. 1337-44 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Human peptide transporters: Therapeutic applications
Nielsen, C. U., Larsen, Birger Brodin, Jørgensen, Flemming Steen, Frøkjær, Sven & Steffansen, B., 1 Sep 2002, In: Expert Opinion on Therapeutic Patents. 12, 9, p. 1329-1350 22 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Carrier-mediated ¿-aminobutyric acid transport across the basolateral membrane of human intestinal Caco-2 cell monolayers
Nielsen, C. U., Carstensen, M. & Larsen, Birger Brodin, 2012, In: European Journal of Pharmaceutics and Biopharmaceutics. 81, 2, p. 458-462Research output: Contribution to journal › Journal article › Research › peer-review
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Sertraline inhibits the transport of PAT1 substrates in vivo and in vitro
Nielsen, C. U., Frølund, S. B., Abdulhadi, S., Sari, H., Langthaler, L., Nøhr, M. K., Kall, M. A., Larsen, Birger Brodin & Holm, R., Nov 2013, In: British Journal of Pharmacology. 170, 5, p. 1041-52 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Recent advances in therapeutic applications of human transporters
Nielsen, C. U., Våbenø, J., Andersen, R., Larsen, Birger Brodin & Steffansen, B., 2005, In: Expert Opinion on Therapeutic Patents. 15, 2, p. 153-166 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Dipeptide model prodrugs for the intestinal oligopeptide transporter. Affinity for and transport via hPepT1 in the human intestinal Caco-2 cell line
Nielsen, C. U., Andersen, R., Larsen, Birger Brodin, Frøkjær, Sven, Taub, M. E. & Steffansen, B., 2001, In: Journal of Controlled Release. 76, 1-2, p. 129-38 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Epidermal growth factor inhibits glycylsarcosine transport and hPepT1 expression in a human intestinal cell line
Nielsen, C. U., Amstrup, J., Steffansen, B., Frøkjær, Sven & Larsen, Birger Brodin, 2001, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 281, 1, p. G191-9Research output: Contribution to journal › Journal article › Research › peer-review
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Di/tri-peptide transporters as drug delivery targets: regulation of transport under physiological and patho-physiological conditions
Nielsen, C. U. & Larsen, Birger Brodin, 2003, In: Current Drug Targets. 4, 5, p. 373-88 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Model prodrugs for the intestinal oligopeptide transporter: model drug release in aqueous solution and in various biological media
Nielsen, C. U., Andersen, R., Larsen, Birger Brodin, Frøkjær, Sven & Steffansen, B., 2001, In: Journal of Controlled Release. 73, 1, p. 21-30 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Generation of an iPSC-line (BIONi010C-48) with restored P-glycoprotein functionality following transfection with the human MDR1 gene in the AAVS1 locus
Nielsen, A. K. R., Lilieholm-Røngren, L., Schmid, B., Holst, B., Larsen, Birger Brodin & Saaby, Lasse, 2024, In: Stem Cell Research. 76, 5 p., 103348.Research output: Contribution to journal › Journal article › Research › peer-review
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Evidence for a Na+/Ca2+ exchange mechanism in frog skin epithelium
Madsen, K. H., Larsen, Birger Brodin & Nielsen, Rasmus, 1999, In: Pflügers Archiv - European Journal of Physiology. 437, 2, p. 175-81 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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In Vitro cutaneous application of ISCOMs on human skin enhances delivery of hydrophobic model compounds through the stratum corneum
Madsen, H. B., Ifversen, P., Madsen, F., Larsen, Birger Brodin, Hausser, I. & Nielsen, Hanne Mørck, 2009, In: The AAPS Journal. 11, 4, p. 728-739Research output: Contribution to journal › Journal article › Research › peer-review
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Evaluating the involvement of cerebral microvascular endothelial Na+/K+-ATPase and Na+-K+-2Cl- co-transporter in electrolyte fluxes in an in vitro blood-brain barrier model of dehydration
Lykke, K., Assentoft, M., Hørlyck, S., Helms, H. C. C., Stoica, A., Toft-Bertelsen, Trine Lisberg, Tritsaris, Katerina, Vilhardt, Frederik, Larsen, Birger Brodin & MacAulay, Nanna, 2019, In: Journal of Cerebral Blood Flow and Metabolism. 39, 3, p. 497-512Research output: Contribution to journal › Journal article › Research › peer-review
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The Cell-Penetrating Peptide Tat Facilitates Effective Internalization of PSD-95 Inhibitors Into Blood–Brain Barrier Endothelial Cells but less Efficient Permeation Across the Blood–Brain Barrier In Vitro and In Vivo
Lisa Al Humaidan, E., Lund Pedersen, S., Burkhart, A., Laurfelt Munch Rasmussen, C., Moos, T., Fuchs, P., Alves Fernandes, E. F., Ozgür, Burak, Strømgaard, K., Bach, Anders, Larsen, Birger Brodin & Kristensen, Mie, 2022, In: Frontiers in Drug Delivery - CNS Drug Delivery. 2, 17 p., 854703.Research output: Contribution to journal › Journal article › Research › peer-review
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Discovery of ligands for the human intestinal di-/tripeptide transporter (hPEPT1) using af QSAR-assisted virtual screening strategy
Larsen, S. B., Omkvist, D. H., Larsen, Birger Brodin, Nielsen, C. U., Steffansen, B., Olsen, L. & Jørgensen, Flemming Steen, 2009, In: ChemMedChem. 4, 9, p. 1439-1445Research output: Contribution to journal › Journal article › Research › peer-review
ID: 1299175
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Design of prodrugs targeting the intestinal di/tri‐peptide transporter hPEPT1 (SLC15A1
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A bovine in vitro blood-brain barrier model under oxygenglucose deprivation (OGD) condition
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