Sven Frøkjær

Sven Frøkjær

Professor, emeritus

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    ORCID: 0000-0002-6621-3784

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    1. Published

      In vitro evaluation of N-methyl amide tripeptidomimetics as substrates for the human intestinal di-/tri-peptide transporter hPEPT1

      Andersen, R., Nielsen, C. U., Begtrup, M., Jørgensen, Flemming Steen, Larsen, Birger Brodin, Frøkjær, Sven & Steffansen, B., 2006, In: European Journal of Pharmaceutical Sciences. 28, 4, p. 325-35 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Characterization of rPEPT2-mediated Gly-Sar transport parameters in the rat kidney proximal tubule cell line SKPT-0193 cl.2 cultured in basic growth media

      Bravo, S. A., Nielsen, C. U., Frøkjær, Sven & Larsen, Birger Brodin, 2005, In: Molecular Pharmaceutics. 2, 2, p. 98-108 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Epidermal growth factor decreases PEPT2 transport capacity and expression in the rat kidney proximal tubule cell line SKPT0193 cl.2

      Bravo, S. A., Nielsen, C. U., Amstrup, J., Frøkjær, Sven & Larsen, Birger Brodin, 2004, In: American Journal of Physiology - Renal Physiology. 286, 2, p. 385-393

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      In-depth evaluation of Gly-Sar transport parameters as a function of culture time in the Caco-2 cell model

      Bravo, S. A., Nielsen, C. U., Amstrup, J., Frøkjær, Sven & Larsen, Birger Brodin, 1 Jan 2004, In: European Journal of Pharmaceutical Sciences. 21, 1, p. 77-86 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Transport of peptidomimetic drugs by the intestinal Di/tri-peptide transporter, PepT1

      Larsen, Birger Brodin, Nielsen, C. U., Steffansen, B. & Frøkjær, Sven, 2002, In: Basic & Clinical Pharmacology & Toxicology. 90, 6, p. 285-96 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      The novel oxygenated chalcone, 2,4-dimethoxy-4'-butoxychalcone, exhibits potent activity against human malaria parasite Plasmodium falciparum in vitro and rodent parasites Plasmodium berghei and Plasmodium yoelii in vivo

      Chen, M., Christensen, Søren Brøgger, Zhai, L., Rasmussen, M. H., Theander, Thor Grundtvig, Frøkjær, Sven, Steffansen, B., Davidsen, J. & Kharazmi, A., 1997, In: Journal of Infectious Diseases. 176, 5, p. 1327-33 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Guidance for pediatric use in prescription information for novel medicinal products in the EU and the US

      Christiansen, H., De Bruin, M. L., Frøkjær, Sven & Hallgreen, Christine Erikstrup, 2022, In: PLoS ONE. 17, 4, 19 p., e0266353.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Preparation and characterization of poly (DL-lactide-co-glycolide) nanoparticles for siRNA delivery

      Cun, D., Foged, Camilla, Yang, Mingshi, Frøkjær, Sven & Nielsen, Hanne Mørck, 2010, In: Internation Journal of Pharmaceutics. 390, 1, p. 70-75

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Enzymatic degradation of polymer covered SOPC-liposomes in relation to drug delivery

      Davidsen, Johan, Vermehren, Charlotte, Frøkjær, Sven, Mouritsen, Ole G. & Jørgensen, K., 29 Jan 2001, In: Advances in Colloid and Interface Science. 89-90, p. 303-311 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Drug delivery by phospholipase A2 degradable liposomes

      Davidsen, J., Vermehren, Charlotte, Frøkjær, Sven, Mouritsen, Ole G. & Jørgensen, K., 19 Feb 2001, In: International Journal of Pharmaceutics. 214, 1-2, p. 67-69 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Kinetics of insulin adsorption at the oil-water interface and diffusion properties of adsorbed layers monitored using fluorescence correlation spectroscopy

      Donsmark, J., Jørgensen, Lene, Mollmann, S., Frøkjær, Sven & Rischel, C., 1 Jan 2006, In: Pharmaceutical Research. 23, 1, p. 148-155 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Kinetics of insulin adsorption and gelation at the oil-water interface monitored using fluorescence correlation spectroscopy

      Donsmark, J., Jørgensen, Lene, Mollmann, S. H., Frøkjær, Sven & Rischel, C., 2006, In: Pharmaceutical Research. 23, 1, p. 148-155

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Ionic strength-dependent denaturation of Thermomyces lanuginosus lipase induced by SDS

      Fanø, M., van de Weert, Marco, Møller, E. H., Kruse, N. A. & Frøkjær, Sven, 2011, In: Archives of Biochemistry and Biophysics. 506, 1, p. 92-98

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Particle size and surface charge affect particle uptake by human dendritic cells in an in vitro model

      Foged, Camilla, Larsen, Birger Brodin, Frøkjær, Sven & Sundblad, A., 2005, In: Internation Journal of Pharmaceutics. 298, 2, p. 315-22 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Cellular uptake and membrane-destabilising properties of a-peptide/ß-peptoid chimeras: lessons for the design of new cell-penetrating peptides

      Foged, Camilla, Franzyk, Henrik, Bahrami, S., Frøkjær, Sven, Jaroszewski, J. W., Nielsen, Hanne Mørck & Olsen, Christian Adam, 2008, In: BBA General Subjects. 1778, 11, p. 2487-2495

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Phospholipase A2 sensitive liposomes for delivery of small interfering RNA (siRNA)

      Foged, Camilla, Nielsen, Hanne Mørck & Frøkjær, Sven, 2007, In: Journal of Liposome Research. 17, 3-4

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Interaction of dendritic cells with antigen-containing liposomes: effect of bilayer composition

      Foged, Camilla, Arigita, C., Sundblad, A., Jiskoot, W., Storm, G. & Frøkjær, Sven, 2004, In: Vaccine. 22, 15-16, p. 1903-13 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Liposomes for phospholipase A2 triggered siRNA release: preparation and in vitro test

      Foged, Camilla, Nielsen, Hanne Mørck & Frøkjær, Sven, 2007, In: Internation Journal of Pharmaceutics. 331, 2, p. 160-166

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Assessment of side-chain modified dipeptides that interact with the oligopeptide transporter

      Frøkjær, Sven, Steffansen, B. & Taub, M. E., 1998, Peptide and Protein Drug Delivery: Alfred Benzon Symposium 43. Munkgaard, p. 287-297 10 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    20. Published

      Peptide and protein drug delivery : proceedings of a symposium held at the Royal Danish Academy of Sciences and Letters, August 17-21, 1997: Alfred Benzon Symposium, 43

      Frøkjær, Sven, Christrup, Lona Louring, Krogsgaard-Larsen, Povl & Alfred Benzon, F., 1998, Copenhagen: Munksgaard .

      Research output: Book/Report › Book › Research

    21. Published

      Formulation, stability and characterization of protein and peptide drugs

      Frøkjær, Sven, Hovgaard, L. & van de Weert, Marco, 2004, Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids. Mahato, R. I. (ed.). Boca Raton: CRC Press, p. 378-401

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication

    22. Published

      Chemical and thermal stability of insulin: effects of zinc and ligand binding to the insulin zinc-hexamer

      Huus, K., Havelund, S., Olsen, H. B., van de Weert, Marco & Frøkjær, Sven, Nov 2006, In: Pharmaceutical Research. 23, 11, p. 2611-20 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Ligand binding and thermostability of different allosteric states of the insulin zinc-hexamer

      Huus, K., Havelund, S., Olsen, H. B., Sigurskjold, B. W., van de Weert, Marco & Frøkjær, Sven, 28 Mar 2006, In: Biochemistry. 45, 12, p. 4014-4024 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Thermal dissociation and unfolding of insulin

      Huus, K., Havelund, S., Olsen, H. B., van de Weert, Marco & Frøkjær, Sven, 23 Aug 2005, In: Biochemistry. 44, 33, p. 11171-7 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Computational prediction of solubilizers' effect on partitioning

      Høst, J., Christensen, I. T., Jørgensen, Flemming Steen, Frøkjær, Sven & Hovgaard, L., 2007, In: Internation Journal of Pharmaceutics. 329, 1-2, p. 46-52

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Spray drying of siRNA-containing PLGA nanoparticles intended for inhalation

      Jensen, D. M. K., Cun, D., Maltesen, M. J., Frøkjær, Sven, Nielsen, Hanne Mørck & Foged, Camilla, 2010, In: Journal of Controlled Release. 142, p. 138-145

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Binding mode of Thioflavin T in insulin amyloid fibrils

      Jensen, M. G., Norrman, M., Flink, J. M., van de Weert, Marco, Bukrinsky, J. T., Schluckebier, G. & Frøkjær, Sven, 2007, In: Journal of Structural Biology. 159, 3, p. 483-497

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Study on the binding of Thioflavin T to ß-sheet-rich and non-ß-sheet cavities

      Jensen, M. G., Olsen, L., van de Weert, Marco, Flink, J. M., Frøkjær, Sven & Jørgensen, Flemming Steen, 2007, In: Journal of Structural Biology. 158, 3, p. 358-369

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Gennembrud i forståelsen af insulinfibrillering

      Jensen, M. G., Vestergaard, Bente, Frøkjær, Sven, Gajhede, Michael, Flink, J. M., van de Weert, Marco, Kastrup, Jette Sandholm Jensen & Svergun, D. I., 2007, In: Lægemiddelforskning. p. 10-11

      Research output: Contribution to journal › Journal article › Communication

    30. Published

      Formation mechanism of insulin fibrils and structural aspects of the insulin fibrillation process

      Jensen, M. G., Frøkjær, Sven & Vestergaard, Bente, 2009, In: Current Protein and Peptide Science. 10, 5, p. 509-528

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Preparing and evaluating delivery systems for proteins

      Jorgensen, L., Moeller, E. H., van de Weert, Marco, Nielsen, H. M. & Frøkjær, Sven, 2006, In: European Journal of Pharmaceutical Sciences. 29, 3-4, p. 174-82 9 p.

      Research output: Contribution to journal › Review › Research › peer-review

    32. Published

      Probing structural changes of proteins incorporated into water-in-oil emulsions

      Jørgensen, Lene, van de Weert, Marco, Vermehren, C., Bjerregaard, S. & Frøkjær, Sven, Jul 2004, In: Journal of Pharmaceutical Sciences. 93, 7, p. 1847-59 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Issues in Development of Biodrug Delivery Systems

      Jørgensen, Lene, Frøkjær, Sven & Nielsen, Hanne Mørck, 2010, Biodrug Delivery Systems: Fundamentals, Applications and Clinical Development. Morishita, M. & Park, K. (eds.). 1 ed. Informa Healthcare, p. 13-25

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    34. Published

      Issues in development of biodrug delivery systems

      Jørgensen, Lene, Frøkjær, Sven & Nielsen, Hanne Mørck, 2010, Biodrug delivery systems: fundamentals, applications and clinical development. Morishita, M. & Park, K. (eds.). New York: Informa Healthcare, p. 13-25

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    35. Published

      Biotechnology-based pharmaceuticals

      Jørgensen, Lene, Nielsen, Hanne Mørck & Frøkjær, Sven, 2009, Modern pharmaceutics: applications and advances. Florence, A. T. & Siepmann, J. (eds.). 5 ed. New York: Informa Healthcare, Vol. 2. p. 259-293 (Drugs and the Pharmaceutical Sciences, Vol. 188).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    36. Published

      In vitro release of insulin aspart incorporated into water-in-oil emulsions

      Jørgensen, Lene, Vermehren, Charlotte, Bjerregaard, S. & Frøkjær, Sven, 2004, In: Journal of Drug Delivery Science and Technology. 14, 6, p. 455-459

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Secondary structure alteration in insulin and growth hormone water-in-oil emulsions

      Jørgensen, Lene, Vermehren, Charlotte, Bjerregaard, S. & Frøkjær, Sven, 2003, In: Internation Journal of Pharmaceutics. 254, 1, p. 7-10

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Micropipette manipulation a technique to evaluate the stability of water-in-oil emulsions containing proteins

      Jørgensen, Lene, Kim, D. H., Vermehren, Charlotte, Bjerregaard, S. & Frøkjær, Sven, 2004, In: Journal of Pharmaceutical Sciences. 93, 12, p. 2994-3003

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Medicon Valley - dansk-svensk succes

      Jørgensen, S., Ahren, B., Jensen, I. S. & Frøkjær, Sven, 14 Mar 2013, In: Morgenavisen Jyllands-Posten. p. 28

      Research output: Contribution to journal › Contribution to newspaper - Feature article › Communication

    40. Published

      Calcipotriol delivery into the skin with PEGylated liposomes

      Knudsen, N. Ø., Rønholt, Stine, Salte, R. D., Jørgensen, Lene, Thormann, T., Basse, L. H., Hansen, J., Frøkjær, Sven & Foged, Camilla, 2012, In: European Journal of Pharmaceutics and Biopharmaceutics. 81, 3, p. 532-9 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Design of cyclic RKKH peptide-conjugated PEG liposomes targeting the integrin a2ß1 receptor

      Knudsen, N. Ø., Schiffelers, R. M., Jørgensen, Lene, Hansen, J., Frøkjær, Sven & Foged, Camilla, 2012, In: International Journal of Pharmaceutics. 428, 1-2, p. 171-177

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Targeting of liposome-associated calcipotriol to the skin: effect of liposomal membrane fluidity and skin barrier integrity

      Knudsen, N. Ø., Jørgensen, Lene, Hansen, J., Vermehren, C., Frøkjær, Sven & Foged, Camilla, 2011, In: International Journal of Pharmaceutics. 416, p. 478-485

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Penetration of gel and liquid state liposomes into barrier-impaired skin

      Knudsen, N. Ø., Frøkjær, Sven, Hansen, J., Jørgensen, Lene & Foged, Camilla, 2010, In: Journal of Pharmacy and Pharmacology. p. 793

      Research output: Contribution to journal › Conference article › Research › peer-review

    44. Published

      Stability and vitro metabolism of dipeptide model prodrugs with affinity for the oligopeptide transporter

      Lepist, E., Steffansen, B., Kusk, T., Larsen, D. H., Andersen, D., Frøkjær, Sven, Taub, M. E., Veski, P. & Lennernas, H., 2000, In: European Journal of Pharmaceutical Sciences. 11, p. 43-50 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Interfacial adsorption of insulin - conformational changes and reversibility of adsorption

      Mollmann, S. H., Jørgensen, Lene, Bukrinsky, J. T., Elofsson, U., Norde, W. & Frøkjær, Sven, 2006, In: European Journal of Pharmaceutical Sciences. 27, 2-3, p. 194-204

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Dipeptide model prodrugs for the intestinal oligopeptide transporter. Affinity for and transport via hPepT1 in the human intestinal Caco-2 cell line

      Nielsen, C. U., Andersen, R., Larsen, Birger Brodin, Frøkjær, Sven, Taub, M. E. & Steffansen, B., 2001, In: Journal of Controlled Release. 76, 1-2, p. 129-38 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Epidermal growth factor inhibits glycylsarcosine transport and hPepT1 expression in a human intestinal cell line

      Nielsen, C. U., Amstrup, J., Steffansen, B., Frøkjær, Sven & Larsen, Birger Brodin, 2001, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 281, 1, p. G191-9

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Model prodrugs for the intestinal oligopeptide transporter: model drug release in aqueous solution and in various biological media

      Nielsen, C. U., Andersen, R., Larsen, Birger Brodin, Frøkjær, Sven & Steffansen, B., 2001, In: Journal of Controlled Release. 73, 1, p. 21-30 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Transport characteristics of L-carnosine and the anticancer derivative 4-toluenesulfonylureido-carnosine in a human epithelial cell line

      Nielsen, C. U., Supuran, C. T., Scozzafava, A., Frøkjær, Sven, Steffansen, B. & Larsen, Birger Brodin, 2002, In: Pharmaceutical Research. 19, 9, p. 1337-44 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Human peptide transporters: Therapeutic applications

      Nielsen, C. U., Larsen, Birger Brodin, Jørgensen, Flemming Steen, Frøkjær, Sven & Steffansen, B., 1 Sep 2002, In: Expert Opinion on Therapeutic Patents. 12, 9, p. 1329-1350 22 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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