Sven Frøkjær

Sven Frøkjær

Professor, emeritus

Member of:

    ORCID: 0000-0002-6621-3784

    Publication year:
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    1 - 50 out of 89Page size: 50
    1. 1996
    2. Published

      Drug delivery studies in Caco-2 monolayers. IV. Ethyl glycoside esters as a novel type of absorption enhancers.

      Nielsen, Hanne Mørck, Brøndsted, H., Frøkjær, Sven & Hovgaard, L., 1996, In: STP pharma sciences. p. 157-161

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Drug delivery studies in Caco-2 monolayers V. Ethyl glucoside esters as a novel type of absorption enhancers

      Nielsen, Hanne Mørck, Brøndsted, H., Frøkjær, Sven & Hovgaard, L., 1 Mar 1996, In: S.T.P. Pharma Sciences. 6, 2, p. 157-161 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. 1997
    5. Published

      Beta-carboxylic acid esterfied D-Asp-Ala retains a high affinity for the oligopeptide transporter in Caco-2 cell monolayers

      Taub, M. E., Larsen, B. D., Steffansen, B. & Frøkjær, Sven, 1997, In: International Journal of Pharmaceutics. 146, p. 205-212 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Influence of oligopeptide transporter binding affinity upon uptake and transport of D-Asp(Obzl)-Ala and Asp(OBzl)-Sar in filter-grown Caco-2 monolayers

      Taub, M. E., Moss, B. A., Steffansen, B. & Frøkjær, Sven, 1997, In: International Journal of Pharmaceutics. 156, p. 219-228 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      The effect of beta-turn structure on the permeation of peptides across monolayers of bovine brain microvessel endothelial cells

      Sørensen, M., Steenberg, B., Knipp, G., Wang, W., Steffansen, B., Frøkjær, Sven & Borchardt, R. T., 1997, In: Pharmaceutical Research. 14, p. 1341-1348

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      The novel oxygenated chalcone, 2,4-dimethoxy-4'-butoxychalcone, exhibits potent activity against human malaria parasite Plasmodium falciparum in vitro and rodent parasites Plasmodium berghei and Plasmodium yoelii in vivo

      Chen, M., Christensen, Søren Brøgger, Zhai, L., Rasmussen, M. H., Theander, Thor Grundtvig, Frøkjær, Sven, Steffansen, B., Davidsen, J. & Kharazmi, A., 1997, In: Journal of Infectious Diseases. 176, 5, p. 1327-33 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. 1998
    10. Published

      Assessment of side-chain modified dipeptides that interact with the oligopeptide transporter

      Frøkjær, Sven, Steffansen, B. & Taub, M. E., 1998, Peptide and Protein Drug Delivery: Alfred Benzon Symposium 43. Munkgaard, p. 287-297 10 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    11. Published

      Oligopeptide transporter mediated uptake and transport of D-Asp(OBzl)-Ala, D-Glu(OBzl)-Ala and D-Ser(Bzl)-Ala in filter grown Caco-2 monolayers

      Taub, M. E., Moss, B. A., Steffansen, B. & Frøkjær, Sven, 1998, In: International Journal of Pharmaceutics. 174, p. 223-232 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Peptide and protein drug delivery : proceedings of a symposium held at the Royal Danish Academy of Sciences and Letters, August 17-21, 1997: Alfred Benzon Symposium, 43

      Frøkjær, Sven, Christrup, Lona Louring, Krogsgaard-Larsen, Povl & Alfred Benzon, F., 1998, Copenhagen: Munksgaard .

      Research output: Book/Report › Book › Research

    13. 1999
    14. Published

      Stability metabolism and transport of D-Asp(OBzl)Ala -a model prodrug with affinity for the oligopeptide transporter

      Steffansen, B., Lepist, E., Frøkjær, Sven, Taub, M. E. & Lennernas, H., 1999, In: European Journal of Pharmaceutical Sciences. 8, p. 67-73

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Phase behavior and lipid-membrane structure of phospholipid- glycosphingolipid liposomes and the thermal unfolding of insulin

      Pedersen, T. B., Frøkjær, Sven, Mouritsen, Ole G. & Jørgensen, K., 1 Jan 1999, In: Journal of Liposome Research. 9, 2, p. 261-274 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. 2000
    17. Published

      Stability and vitro metabolism of dipeptide model prodrugs with affinity for the oligopeptide transporter

      Lepist, E., Steffansen, B., Kusk, T., Larsen, D. H., Andersen, D., Frøkjær, Sven, Taub, M. E., Veski, P. & Lennernas, H., 2000, In: European Journal of Pharmaceutical Sciences. 11, p. 43-50 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. 2001
    19. Published

      Dipeptide model prodrugs for the intestinal oligopeptide transporter. Affinity for and transport via hPepT1 in the human intestinal Caco-2 cell line

      Nielsen, C. U., Andersen, R., Larsen, Birger Brodin, Frøkjær, Sven, Taub, M. E. & Steffansen, B., 2001, In: Journal of Controlled Release. 76, 1-2, p. 129-38 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Epidermal growth factor inhibits glycylsarcosine transport and hPepT1 expression in a human intestinal cell line

      Nielsen, C. U., Amstrup, J., Steffansen, B., Frøkjær, Sven & Larsen, Birger Brodin, 2001, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 281, 1, p. G191-9

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Model prodrugs for the intestinal oligopeptide transporter: model drug release in aqueous solution and in various biological media

      Nielsen, C. U., Andersen, R., Larsen, Birger Brodin, Frøkjær, Sven & Steffansen, B., 2001, In: Journal of Controlled Release. 73, 1, p. 21-30 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Enzymatic degradation of polymer covered SOPC-liposomes in relation to drug delivery

      Davidsen, Johan, Vermehren, Charlotte, Frøkjær, Sven, Mouritsen, Ole G. & Jørgensen, K., 29 Jan 2001, In: Advances in Colloid and Interface Science. 89-90, p. 303-311 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Association of an acylated model peptide with DPPC-DPPS lipid membranes

      Pedersen, T. B., Sabra, M. C., Frøkjær, Sven, Mouritsen, Ole G. & Jørgensen, K., 19 Feb 2001, In: International Journal of Pharmaceutics. 214, 1-2, p. 77-81 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Drug delivery by phospholipase A2 degradable liposomes

      Davidsen, J., Vermehren, Charlotte, Frøkjær, Sven, Mouritsen, Ole G. & Jørgensen, K., 19 Feb 2001, In: International Journal of Pharmaceutics. 214, 1-2, p. 67-69 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Association of acylated cationic decapeptides with dipalmitoylphosphatidylserine-dipalmitoylphosphatidylcholine lipid membranes

      Pedersen, T. B., Sabra, M. C., Frøkjær, Sven, Mouritsen, Ole G. & Jørgensen, K., 7 Nov 2001, In: Chemistry and Physics of Lipids. 113, 1-2, p. 83-95 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. 2002
    27. Published

      Transport characteristics of L-carnosine and the anticancer derivative 4-toluenesulfonylureido-carnosine in a human epithelial cell line

      Nielsen, C. U., Supuran, C. T., Scozzafava, A., Frøkjær, Sven, Steffansen, B. & Larsen, Birger Brodin, 2002, In: Pharmaceutical Research. 19, 9, p. 1337-44 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Transport of peptidomimetic drugs by the intestinal Di/tri-peptide transporter, PepT1

      Larsen, Birger Brodin, Nielsen, C. U., Steffansen, B. & Frøkjær, Sven, 2002, In: Basic & Clinical Pharmacology & Toxicology. 90, 6, p. 285-96 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      A calorimetric study of phosphocholine membranes mixed with desmopressin and its diacylated prodrug derivative (DPP)

      Pedersen, T. B., Frøkjær, Sven, Mouritsen, Ole G. & Jørgensen, K., 21 Feb 2002, In: International Journal of Pharmaceutics. 233, 1-2, p. 199-206 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Human peptide transporters: Therapeutic applications

      Nielsen, C. U., Larsen, Birger Brodin, Jørgensen, Flemming Steen, Frøkjær, Sven & Steffansen, B., 1 Sep 2002, In: Expert Opinion on Therapeutic Patents. 12, 9, p. 1329-1350 22 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. 2003
    32. Published

      Prodrugs

      Steffansen, B., Thomsen, A. E. & Frøkjær, Sven, 2003, Estimation of solubility, permeability, absorption and bioavaibility. van de Waterbeemd, H., Lennernäs, H. & Artursson, P. (eds.). Weinheim: Wiley-VCH, p. 532-546

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    33. Published

      Prodrugs of purine and pyrimidine analogues for the intestinal di/tri-peptide transporter PepT1: affinity for hPepT1 in Caco-2 cells, drug release in aqueous media and in vitro metabolism

      Thomsen, A. E., Friedrichsen, G. M., Sørensen, A. H., Andersen, R., Nielsen, C. U., Larsen, Birger Brodin, Begtrup, M., Frøkjær, Sven & Steffansen, B., 2003, In: Journal of Controlled Release. 86, 2-3, p. 279-92 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Secondary structure alteration in insulin and growth hormone water-in-oil emulsions

      Jørgensen, Lene, Vermehren, Charlotte, Bjerregaard, S. & Frøkjær, Sven, 2003, In: Internation Journal of Pharmaceutics. 254, 1, p. 7-10

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Erratum: Prodrugs of purine and pyrimidine analogues for the intestinal di/tri-peptide transporter PepT1: Affinity for hPepT1 in Caco-2 cells, drug release in aqueous media and in vitro metabolism (Journal of Controlled Release (2003) 86 (279-292) PII: S0168365902004133)

      Thomsen, A. E., Friedrichsen, G. M., Sørensen, A. H., Andersen, R., Nielsen, C. U., Larsen, Birger Brodin, Begtrup, M., Frøkjær, Sven & Steffansen, B., 7 Mar 2003, In: Journal of Controlled Release. 88, 2

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      In vitro and in vivo aspects of N-acyl-phosphatidylethanolamine-containing liposomes

      Vermehren, Charlotte, Clausen-Beck, B., Frøkjær, Sven & Hansen, Harald S., 18 Mar 2003, In: International Journal of Pharmaceutics. 254, 1, p. 49-53 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. 2004
    38. Published

      Epidermal growth factor decreases PEPT2 transport capacity and expression in the rat kidney proximal tubule cell line SKPT0193 cl.2

      Bravo, S. A., Nielsen, C. U., Amstrup, J., Frøkjær, Sven & Larsen, Birger Brodin, 2004, In: American Journal of Physiology - Renal Physiology. 286, 2, p. 385-393

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Formulation, stability and characterization of protein and peptide drugs

      Frøkjær, Sven, Hovgaard, L. & van de Weert, Marco, 2004, Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids. Mahato, R. I. (ed.). Boca Raton: CRC Press, p. 378-401

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication

    40. Published

      In vitro release of insulin aspart incorporated into water-in-oil emulsions

      Jørgensen, Lene, Vermehren, Charlotte, Bjerregaard, S. & Frøkjær, Sven, 2004, In: Journal of Drug Delivery Science and Technology. 14, 6, p. 455-459

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Interaction of dendritic cells with antigen-containing liposomes: effect of bilayer composition

      Foged, Camilla, Arigita, C., Sundblad, A., Jiskoot, W., Storm, G. & Frøkjær, Sven, 2004, In: Vaccine. 22, 15-16, p. 1903-13 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Intestinal solute carriers: an overview of trends and strategies for improving oral drug absorption

      Steffansen, B., Nielsen, C. U., Larsen, Birger Brodin, Eriksson, A. H., Andersen, R. & Frøkjær, Sven, 2004, In: European Journal of Pharmaceutical Sciences. 21, 1, p. 3-16 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Micropipette manipulation a technique to evaluate the stability of water-in-oil emulsions containing proteins

      Jørgensen, Lene, Kim, D. H., Vermehren, Charlotte, Bjerregaard, S. & Frøkjær, Sven, 2004, In: Journal of Pharmaceutical Sciences. 93, 12, p. 2994-3003

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      In-depth evaluation of Gly-Sar transport parameters as a function of culture time in the Caco-2 cell model

      Bravo, S. A., Nielsen, C. U., Amstrup, J., Frøkjær, Sven & Larsen, Birger Brodin, 1 Jan 2004, In: European Journal of Pharmaceutical Sciences. 21, 1, p. 77-86 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Effects of sucrose on rFVIIa aggregation and methionine oxidation

      Soenderkaer, S., Carpenter, J. F., van de Weert, Marco, Hansen, L. L., Flink, J. & Frøkjær, Sven, Apr 2004, In: European Journal of Pharmaceutical Sciences. 21, 5, p. 597-606 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Probing structural changes of proteins incorporated into water-in-oil emulsions

      Jørgensen, Lene, van de Weert, Marco, Vermehren, C., Bjerregaard, S. & Frøkjær, Sven, Jul 2004, In: Journal of Pharmaceutical Sciences. 93, 7, p. 1847-59 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Complex coacervation of lysozyme and heparin: complex characterization and protein stability

      van de Weert, Marco, Andersen, M. B. & Frøkjær, Sven, Dec 2004, In: Pharmaceutical Research. 21, 12, p. 2354-9 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. 2005
    49. Published

      Characterization of rPEPT2-mediated Gly-Sar transport parameters in the rat kidney proximal tubule cell line SKPT-0193 cl.2 cultured in basic growth media

      Bravo, S. A., Nielsen, C. U., Frøkjær, Sven & Larsen, Birger Brodin, 2005, In: Molecular Pharmaceutics. 2, 2, p. 98-108 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Delivery aspects of small peptides and substrates for peptide transporters

      Steffansen, B., Nielsen, C. U. & Frøkjær, Sven, 2005, In: European Journal of Pharmaceutics and Biopharmaceutics. 60, 4, p. 241-245 4 p.

      Research output: Contribution to journal › Review › Research › peer-review

    51. Published

      Evaluation of statistical design/modeling for prediction of the effect of amino acids on agitation-induced aggregation of human growth hormone and human insulin

      Soenderkaer, S., van de Weert, Marco, Lindgaard Hansen, L., Flink, J. & Frøkjær, Sven, 2005, In: Journal of Drug Delivery Science and Technology. 15, 6, p. 427-434 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    52. Published

      Particle size and surface charge affect particle uptake by human dendritic cells in an in vitro model

      Foged, Camilla, Larsen, Birger Brodin, Frøkjær, Sven & Sundblad, A., 2005, In: Internation Journal of Pharmaceutics. 298, 2, p. 315-22 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    53. Published

      Complex coacervation with heparin results in decreased lysozyme stability

      van de Weert, Marco, Bendix Andersen, M. & Frøkjær, Sven, 3 Jan 2005, In: Journal of controlled release : official journal of the Controlled Release Society. 101, 1-3, p. 361-2 2 p.

      Research output: Contribution to journal › Conference abstract in journal › Research

    54. Published

      Thermal dissociation and unfolding of insulin

      Huus, K., Havelund, S., Olsen, H. B., van de Weert, Marco & Frøkjær, Sven, 23 Aug 2005, In: Biochemistry. 44, 33, p. 11171-7 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    55. Published

      Phase behavior and nanoscale structure of phospholipid membranes incorporated with acylated C14-peptides

      Pedersen, T. B., Kaasgaard, T., Jensen, M., Frøkjær, Sven, Mouritsen, Ole G. & Jørgensen, K., Oct 2005, In: Biophysical Journal. 89, 4, p. 2494-2503 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    56. Published

      Factors of importance for a successful delivery system for proteins

      van de Weert, Marco, Jørgensen, Lene, Horn Moeller, E. & Frøkjær, Sven, Nov 2005, In: Expert Opinion on Drug Delivery. 2, 6, p. 1029-37 9 p.

      Research output: Contribution to journal › Review › Research › peer-review

    57. 2006
    58. Published

      In vitro evaluation of N-methyl amide tripeptidomimetics as substrates for the human intestinal di-/tri-peptide transporter hPEPT1

      Andersen, R., Nielsen, C. U., Begtrup, M., Jørgensen, Flemming Steen, Larsen, Birger Brodin, Frøkjær, Sven & Steffansen, B., 2006, In: European Journal of Pharmaceutical Sciences. 28, 4, p. 325-35 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    59. Published

      Interfacial adsorption of insulin - conformational changes and reversibility of adsorption

      Mollmann, S. H., Jørgensen, Lene, Bukrinsky, J. T., Elofsson, U., Norde, W. & Frøkjær, Sven, 2006, In: European Journal of Pharmaceutical Sciences. 27, 2-3, p. 194-204

      Research output: Contribution to journal › Journal article › Research › peer-review

    60. Published

      Kinetics of insulin adsorption and gelation at the oil-water interface monitored using fluorescence correlation spectroscopy

      Donsmark, J., Jørgensen, Lene, Mollmann, S. H., Frøkjær, Sven & Rischel, C., 2006, In: Pharmaceutical Research. 23, 1, p. 148-155

      Research output: Contribution to journal › Journal article › Research › peer-review

    61. Published

      Preparing and evaluating delivery systems for proteins

      Jorgensen, L., Moeller, E. H., van de Weert, Marco, Nielsen, H. M. & Frøkjær, Sven, 2006, In: European Journal of Pharmaceutical Sciences. 29, 3-4, p. 174-82 9 p.

      Research output: Contribution to journal › Review › Research › peer-review

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