Marco van de Weert
Associate Professor
Drug Delivery and Biophysics of Biopharmaceuticals
Universitetsparken 2
2100 København Ø
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Viscosity of high concentration protein formulations of monoclonal antibodies of the IgG1 and IgG4 subclass - Prediction of viscosity through protein-protein interaction measurements
Neergaard, M. S., Kalonia, D. S., Parshad, H., Nielsen, A., Møller, E. H., van de Weert, Marco & Nielsen, A. D., 26 Apr 2013, In: European Journal of Pharmaceutical Sciences. 49, 3, p. 400-410 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Thioflavin T hydroxylation at basic pH and its effect on amyloid fibril detection
Foderà, Vito, Jensen, M. G., Vetri, V., Librizzi, F., Spagnolo, S., Cornett, Claus, Olsen, L., van de Weert, Marco & Leone, M., 2008, In: Journal of Physical Chemistry. 112, 47, p. 15174-15181Research output: Contribution to journal › Journal article › Research › peer-review
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Thermal dissociation and unfolding of insulin
Huus, K., Havelund, S., Olsen, H. B., van de Weert, Marco & Frøkjær, Sven, 23 Aug 2005, In: Biochemistry. 44, 33, p. 11171-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Thermal and acid denaturation of bovine lens a-crystallin
Rasmussen, T., van de Weert, Marco, Jiskoot, W. & Kasimova, M. R., 2011, In: Proteins - Structure Function and Bioinformatics. 79, 6, p. 1747-1758Research output: Contribution to journal › Journal article › Research › peer-review
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The molecular chaperone a-crystallin as an excipient in an insulin formulation
Rasmussen, T., Tantipolphan, R., van de Weert, Marco & Jiskoot, W., 2010, In: Pharmaceutical Research. 27, p. 1337-1347Research output: Contribution to journal › Journal article › Research › peer-review
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The effect of a water/organic solvent interface on the structural stability of lysozyme
van de Weert, Marco, Hoechstetter, J., Hennink, W. E. & Crommelin, D. J. A., 2000, In: Journal of Controlled Release. p. 351-359Research output: Contribution to journal › Journal article › Research › peer-review
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The chaperone-like protein a-crystallin dissociates insulin dimers and hexamers
Rasmussen, T., Kasimova, M. R., Jiskoot, W. & van de Weert, Marco, 2009, In: Biochemistry. 48, p. 9313-9320Research output: Contribution to journal › Journal article › Research › peer-review
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The challenges in and importance of analysing protein structure and physical stability in complex formulations
Jørgensen, Lene, Jensen, M. G., Roest, N., Pinholt, C. & van de Weert, Marco, 1 Jul 2013, In: Journal of Drug Delivery Science and Technology. 23, 4, p. 347-353 7 p.Research output: Contribution to journal › Review › Research › peer-review
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The Inhibitory Effect of Natural Products on Protein Fibrillation May Be Caused by Degradation Products – A Study Using Aloin and Insulin
Lobbens, E. S., Foderà, Vito, Nyberg, N., Andersen, K., Jäger, A. K., Jørgensen, Lene & van de Weert, Marco, 16 Feb 2016, In: PloS one. 11, 2, p. 1-16 16 p., e0149148.Research output: Contribution to journal › Journal article › Research › peer-review
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The Effect of Protein PEGylation on Physical Stability in Liquid Formulation
Holm, L. S., Mcumber, A., Rasmussen, J. E., Obiols-Rabasa, M., Thulstrup, Peter Waaben, Kasimova, M. R., Randolph, T. W. & van de Weert, Marco, 21 Aug 2014, In: Journal of Pharmaceutical Sciences. 103, 10, p. 3043-3054 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Taylor Dispersion Analysis as a promising tool for assessment of peptide-peptide interactions
Høgstedt, U. B., Schwach, G., van de Weert, Marco & Østergaard, Jesper, 25 Jul 2016, In: European Journal of Pharmaceutical Sciences. 93, p. 21-28 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Study on the binding of Thioflavin T to ß-sheet-rich and non-ß-sheet cavities
Jensen, M. G., Olsen, L., van de Weert, Marco, Flink, J. M., Frøkjær, Sven & Jørgensen, Flemming Steen, 2007, In: Journal of Structural Biology. 158, 3, p. 358-369Research output: Contribution to journal › Journal article › Research › peer-review
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Studies on human insulin adsorption kinetics at an organic-aqueous interface determined using a label-free electroanalytical approach
Thomsen, A. E., Jensen, H., Jørgensen, Lene, van de Weert, Marco & Østergaard, Jesper, 2008, In: Colloids and Surfaces B: Biointerfaces. 63, 2, p. 243-248Research output: Contribution to journal › Journal article › Research › peer-review
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Stability of monoclonal antibodies at high-concentration: head-to-head comparison of the IgG1 and IgG4 subclass
Neergaard, M. S., Nielsen, A. D., Parshad, H. & van de Weert, Marco, Jan 2014, In: Journal of Pharmaceutical Sciences. 103, 1, p. 115-27 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Stability aspects of salmon calcitonin entrapped in poly(ether-ester) sustained release systems
van Dijkhuizen-Radersma, R., Nicolas, H. M., van de Weert, Marco, Blom, M., de Groot, K. & Bezemer, J. M., 6 Nov 2002, In: International Journal of Pharmaceutics. 248, 1-2, p. 229-37 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Spray dried cubosomes with ovalbumin and Quil-A as a nanoparticulate dry powder vaccine formulation
von Halling Laier, C., Gibson, B., van de Weert, Marco, Boyd, B. J., Rades, Thomas, Boisen, A., Hook, S. & Nielsen, L. H., 25 Oct 2018, In: International Journal of Pharmaceutics. 550, 1-2, p. 35-44 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Small angle X-ray scattering-based elucidation of the self-association mechanism of human insulin analogue lys(B29)(N(e)¿-carboxyheptadecanoyl) des(B30)
Jensen, M. H., Wahlund, P., Toft, K. N., Jacobsen, J. K., Steensgaard, D. B., van de Weert, Marco, Havelund, S. & Vestergaard, Bente, 15 Jan 2013, In: Biochemistry. 52, 2, p. 282-94 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Serial Coupling of Ion-Exchange and Size-Exclusion Chromatography to Determine Aggregation Levels in mAbs in The Presence of a Proteinaceous Excipient, Recombinant Human Serum Albumin
Weisbjerg, P. L. G., Caspersen, M. B., Cook, K. & van de Weert, Marco, 1 Dec 2014, In: Journal of Pharmaceutical Sciences. 104, 2, p. 548-556 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Semisolid, self-catalyzed poly(ortho ester)s as controlled-release systems: protein release and protein stability issues
van de Weert, Marco, van Steenbergen, M. J., Cleland, J. L., Heller, J., Hennink, W. E. & Crommelin, D. J. A., Apr 2002, In: Journal of Pharmaceutical Sciences. 91, 4, p. 1065-74 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Self-association of long-acting insulin analogues studied by size exclusion chromatography coupled to multi-angle light scattering
Jensen, M. H., Wahlund, P., Jacobsen, J. K., Vestergaard, Bente, van de Weert, Marco & Havelund, S., 2011, In: Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 879, 28, p. 2945-2951Research output: Contribution to journal › Journal article › Research › peer-review
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Secondary nucleation and accessible surface in insulin amyloid fibril formation
Foderà, Vito, Librizzi, F., Jensen, M. G., van de Weert, Marco & Leone, M., 2008, In: Journal of Physical Chemistry B. 112, 12, p. 3853-3858Research output: Contribution to journal › Journal article › Research › peer-review
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Screening of plants used in the European traditional medicine to treat memory disorders for acetylcholinesterase inhibitory activity and anti amyloidogenic activity
Lobbens, E. S. B., Vissing, K. J., Jørgensen, Lene, van de Weert, Marco & Jäger, A. K., 22 Mar 2017, In: Journal of Ethnopharmacology. 200, p. 66-73 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Rhamnogalacturonan-I based microcapsules for targeted drug release
Svagan, A. J., Kusic, A., De Gobba, Cristian, Larsen, F. H., Sassene, P., Zhou, Q., van de Weert, Marco, Mullertz, Anette , Jørgensen, Bodil & Ulvskov, Peter, 2016, In: P L o S One. 11, 12, 13 p., e0168050.Research output: Contribution to journal › Journal article › Research › peer-review
Reversible aggregation of lysozyme in a biodegradable amphiphilic multiblock copolymer
van de Weert, Marco, van Dijkhuizen-Radersma, R., Bezemer, J. M., Hennink, W. E. & Crommelin, D. J. A., Jul 2002, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 54, 1, p. 89-93 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Rapid Conformational Analysis of Protein Drugs in Formulation by Hydrogen/Deuterium Exchange Mass Spectrometry (HDX-MS)
Esmail Nazari, Z., van de Weert, Marco, Bou-Assaf, G., Houde, D., Weiskopf, A. & Rand, Kasper Dyrberg, 1 Jul 2016, In: Journal of Pharmaceutical Sciences. 105, 11, p. 3269–3277 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Quality by design: Spray drying of insulin intended for inhalation
Maltesen, M. J., Bjerregaard, S., Hovgaard, L., Havelund, S. & van de Weert, Marco, 2008, In: European Journal of Pharmaceutics and Biopharmaceutics. 70, 3, p. 828-838Research output: Contribution to journal › Journal article › Research › peer-review
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Protein pharmaceuticals
van de Weert, Marco & Møller, E. H., 2008, In: Drug Discovery Today: Technologies. 5, 2-3, p. 35-36Research output: Contribution to journal › Editorial › Research
Protein instability in poly(lactic-co-glycolic acid) microparticles
van de Weert, Marco, Jiskoot, W. & Hennink, W. E., 2000, In: Pharmaceutical Research. 17, p. 1159-1167Research output: Contribution to journal › Review › Research › peer-review
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Protein adsorption at charged surfaces: The role of electrostatic interactions and interacial charge regulation
Hartvig, R. A., van de Weert, Marco, Østergaard, Jesper, Jørgensen, Lene & Jensen, H., 2011, In: Langmuir. 27, p. 2634-2643Research output: Contribution to journal › Journal article › Research › peer-review
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Protein adsorption at charged surfaces: the role of electrostatic interactions and interfacial charge regulation
Hartvig, R. A., van de Weert, Marco, Østergaard, Jesper, Jørgensen, Lene & Jensen, Henrik Elvang, 15 Mar 2011, In: Langmuir. 27, 6, p. 2634-2643 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Protease and amylase stability in the presence of chelators used in laundry detergent applications: correlation between chelator properties and enzyme stability in liquid detergents
Lund, H., Kaasgaard, S. G., Skagerlind, P., Jørgensen, Lene, Jørgensen, C. I. & van de Weert, Marco, 2012, In: Journal of Surfactants and Detergents. 15, 3, p. 265-276Research output: Contribution to journal › Journal article › Research › peer-review
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Probing structural changes of proteins incorporated into water-in-oil emulsions
Jørgensen, Lene, van de Weert, Marco, Vermehren, C., Bjerregaard, S. & Frøkjær, Sven, Jul 2004, In: Journal of Pharmaceutical Sciences. 93, 7, p. 1847-59 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Probing insulin's secondary structure after entrapment into alginate/chitosan nanoparticles
Sarmento, B., Ferreira, D. C., Jørgensen, Lene & van de Weert, Marco, 2007, In: European Journal of Pharmaceutics and Biopharmaceutics. 65, 1, p. 10-17Research output: Contribution to journal › Journal article › Research › peer-review
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Preparing and evaluating delivery systems for proteins
Jorgensen, L., Moeller, E. H., van de Weert, Marco, Nielsen, H. M. & Frøkjær, Sven, 2006, In: European Journal of Pharmaceutical Sciences. 29, 3-4, p. 174-82 9 p.Research output: Contribution to journal › Review › Research › peer-review
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Preferential interactions and the effect of protein PEGylation
Holm, L. S., Thulstrup, Peter Waaben, Kasimova, M. R. & van de Weert, Marco, 2015, In: PLOS ONE. 10, 7, 18 p., e0133584.Research output: Contribution to journal › Journal article › Research › peer-review
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Preface
van de Weert, Marco & Møller, E. H., 2008, Immunogenicity of biopharmaceuticals. van de Weert, M. & Møller, E. H. (eds.). 1 ed. New York: Springer, p. v-viResearch output: Chapter in Book/Report/Conference proceeding › Preface/postscript › Research
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Polysorbate 80 controls Morphology, structure and stability of human insulin Amyloid-Like spherulites
Zhou, X., Fennema Galparsoro, D., Madsen, Anders Østergaard, Vetri, V., van de Weert, Marco, Nielsen, Hanne Mørck & Foderà, Vito, 2022, In: Journal of Colloid and Interface Science. 606, Pt 2, p. 1928-1939Research output: Contribution to journal › Journal article › Research › peer-review
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On the purported "backbone fluorescence" in protein three-dimensional fluorescence spectra
Bortolotti, A., Wong, Y. H., Korsholm, S. S., Bahring, N. H. B., Bobone, S., Tayyab, S., van de Weert, Marco & Stella, L., 2016, In: RSC Advances. 6, 114, p. 112870-112876 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Multivariate analysis of phenol in freeze-dried and spray-dried insulin formulations by NIR and FTIR
Maltesen, M. J., Bjerregaard, S., Hovgaard, L., Havelund, S., van de Weert, Marco & Grohganz, Holger, 2011, In: A A P S PharmSciTech. 12, 2, p. 627-635Research output: Contribution to journal › Journal article › Research › peer-review
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Medicines authority regulators and industry perspectives on the European regulation of biosimilars
Druedahl, Louise C., De Bruin, M. L. (., van de Weert, Marco, Minssen, Timo, Hoogland, H. & Almarsdóttir, Anna Birna, 2019.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Mechanistic study of the inhibitory activity of Geum urbanum extract against α-Synuclein fibrillation
Lobbens, E. S., Breydo, L., Pedersen, T. S., Vestergaard, Bente, Jäger, A. K., Jørgensen, Lene, Uversky, V. & van de Weert, Marco, 21 Jun 2016, In: B B A - Proteins and Proteomics. 1864, 9, p. 1160-1169 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Mass spectrometric analysis of oxidized tryptophan
van de Weert, Marco, Lagerwerf, F. M., Haverkamp, J. & Heerma, W., 1998, In: Journal of Mass Spectrometry. 33, p. 884-891Research output: Contribution to journal › Journal article › Research › peer-review
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Manipulating Aggregation Behavior of the Uncharged Peptide Carbetocin
Høgstedt, U. B., Østergaard, Jesper, Weiss, T., Sjögren, H. & van de Weert, Marco, Mar 2018, In: Journal of Pharmaceutical Sciences. 107, 3, p. 838-847 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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MEDICINES AUTHORITY REGULATOR AND INDUSTRY PERCEPTIONS OF BIOSIMILAR INTERCHANGEABILITY
Druedahl, Louise C., De Bruin, M. L., Hoogland, H., Minssen, Timo, van de Weert, Marco, Kälvemark Sporrong, Sofia & Almarsdóttir, Anna Birna, Dec 2019, p. E45-E46.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Lysozyme distribution and conformation in a biodegradable polymer matrix as determined by FTIR techniques
van de Weert, Marco, Van 'T Hof, R., Van Der Weerd, J., Heeren, R. M. A., Posthuma, G., Hennink, W. E. & Crommelin, D. J. A., 31 Jul 2000, In: Journal of Controlled Release. 68, 1, p. 31-40 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Lipidation effect on surface adsorption and associated fibrillation of the model protein insulin
Hedegaard, S. C. F., Cardenas Gomez, M., Barker, R., Jørgensen, Lene & van de Weert, Marco, 2016, In: Langmuir. 32, 28, p. 7241–7249 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Ligand binding and thermostability of different allosteric states of the insulin zinc-hexamer
Huus, K., Havelund, S., Olsen, H. B., Sigurskjold, B. W., van de Weert, Marco & Frøkjær, Sven, 28 Mar 2006, In: Biochemistry. 45, 12, p. 4014-4024 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Large-scale polymorphism and auto-catalytic effect in insulin fibrillogenesis
Foderà, Vito, van de Weert, Marco & Vestergaard, Bente, 2010, In: Soft Matter. 6, 18, p. 4413-4419Research output: Contribution to journal › Journal article › Research › peer-review
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Large-scale biophysical evaluation of protein PEGylation effects: in vitro properties of 61 protein entities
Vernet, E., Popa, G., Pozdnyakova, I., Rasmussen, J. E., Grohganz, Holger, Giehm, L., Jensen, M. H., Wang, H., Plesner, B., Nielsen, Hanne Mørck, Jensen, Knud Jørgen, Berthelsen, J., Sundström, M. & van de Weert, Marco, 2016, In: Molecular Pharmaceutics. 13, 5, p. 1587-1598 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 1302800
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Preferential interactions and the effect of protein PEGylation
Research output: Contribution to journal › Journal article › Research › peer-review
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431
downloads
On the purported "backbone fluorescence" in protein three-dimensional fluorescence spectra
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
293
downloads
Rhamnogalacturonan-I based microcapsules for targeted drug release
Research output: Contribution to journal › Journal article › Research › peer-review
Published