Lasse Saaby

Lasse Saaby

Affiliated Associate Professor, Guest Researcher

Member of:

    ORCID: 0000-0003-4271-8304

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    1. Published

      iP-gp , a novel cell line with tight barrier function and expression of human P-glycoprotein (ABCB1) for drug screening

      Larsen, Birger Brodin, Ozgür, Burak & Saaby, Lasse, 23 May 2017.

      Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

    2. Published

      Ubiquitous plant compounds disturb cell-based assays

      Saaby, Lasse & Jäger, A. K., 1 Sep 2011, In: Journal of Ethnopharmacology. 137, 1, p. 942-943

      Research output: Contribution to journal › Comment/debate › Research › peer-review

    3. Published

      Triterpene Acids from Rose Hip Powder Inhibit Self-antigen- and LPS-induced Cytokine Production and CD4(+) T-cell Proliferation in Human Mononuclear Cell Cultures

      Saaby, Lasse & Nielsen, Claus Henrik, Aug 2012, In: Phytotherapy Research. 26, 8, p. 1142-1147 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      The putative proton-coupled organic cation antiporter is involved in uptake of triptans into human brain capillary endothelial cells

      Svane, Nana Isabella, Pedersen, Alberte Bay Villekjær, Rodenberg, A., Ozgür, Burak, Saaby, Lasse, Bundgaard, C., Kristensen, Mie, Tfelt-Hansen, P. & Larsen, Birger Brodin, 2024, In: Fluids and Barriers of the CNS.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      The putative P-gp inhibitor telmisartan does not affect the transcellular permeability and cellular uptake of the calcium channel antagonist verapamil in the P-glycoprotein expressing cell line MDCK II MDR1

      Saaby, Lasse, Tfelt-Hansen, P. & Larsen, Birger Brodin, 11 Jun 2015, In: Pharmacology Research & Perspectives. 3, 4, p. 1-9 9 p., e00151.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      The iP-gp cell model is an improved tool for predicting the in vivo relevance of P-gp mediated efflux at the blood-brain barrier

      Ozgür, Burak, Saaby, Lasse, Eneberg, E., Langthaler, K., Jacobsen, A., Janfelt, Christian, Badolo, L., Montanari, D. & Larsen, Birger Brodin, 22 Jun 2018.

      Research output: Contribution to conference › Poster › Research › peer-review

    7. Published

      The Pyrazolo[3,4-d]pyrimidine Derivative, SCO-201, Reverses Multidrug Resistance Mediated by ABCG2/BCRP

      Ambjørner, S. E. B., Wiese, M., Köhler, S. C., Svindt, J., Lund, X. L., Gajhede, Michael, Saaby, Lasse, Larsen, Birger Brodin, Rump, S., Weigt, H., Brünner, N. & Stenvang, Jan, 4 Mar 2020, In: Cells. 9, 3, 22 p., 613.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      THE POSSIBLE EFFECT OF TELMISARTAN ON THE BLOOD-BRAIN BARRIER TRANSPORT OF VERAPAMIL.

      Saaby, Lasse, Tfelt-Hansen, P. & Larsen, Birger Brodin, 18 Sep 2014. 1 p.

      Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

    9. Published

      Survival of Lactobacillus acidophilus NCFM® and Bifidobacterium lactis HN019 encapsulated in chocolate during in vitro simulated passage of the upper gastrointestinal tract

      Klindt-Toldam, S., Larsen, S. K., Saaby, Lasse, Olsen, L. R., Svenstrup, G., Mullertz, Anette , Knoechel, Susanne, Heimdal, H., Nielsen, Dennis Sandris & Zielińska, D., 2016, In: Lebensmittel - Wissenschaft und Technologie. 74, p. 404-410 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Screening novel CNS drug candidates for P-glycoprotein interactions using the cell line iP-gp: In vitro efflux ratios from iP-gp and MDCK-MDR1 monolayers compared to brain distribution data from mice

      Ozgür, Burak, Saaby, Lasse, Janfelt, Christian, Langthaler, K., Eneberg, E., Jacobsen, A., Badolo, L., Montanari, D. & Larsen, Birger Brodin, 2021, In: European Journal of Pharmaceutics and Biopharmaceutics. 169, p. 211-219

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      SEDDS for intestinal absorption of insulin: Application of Caco-2 and Caco-2/HT29 co-culture monolayers and intra-jejunal instillation in rats

      Liu, J., Werner, U., Funke, M., Besenius, M., Saaby, Lasse, Fano, M., Mu, Huiling & Mullertz, Anette , 5 Apr 2019, In: International Journal of Pharmaceutics. 560, p. 377-384

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Physical and barrier changes in gastrointestinal mucus induced by the permeation enhancer sodium 8-[(2-hydroxybenzoyl)amino]octanoate (SNAC)

      Mortensen, Janni Støvring, Bohr, S. S. R., Rønholt, Stine, Hatzakis, Nikos, Saaby, Lasse & Nielsen, Hanne Mørck, 2022, In: Journal of Controlled Release. 352, p. 163-178 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Neonatal intestinal mucus barrier changes in response to maturity, inflammation, and sodium decanoate supplementation

      Mortensen, Janni Støvring, Bohr, S. S. R., Krog, Lasse Skjoldborg, Bøtker, Johan Peter, Kapousidou, V., Saaby, Lasse, Hatzakis, Nikos, Nielsen, Hanne Mørck, Nguyen, Duc Ninh & Rønholt, Stine, 2024, In: Scientific Reports. 14, 1, 17 p., 7665.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      MAO-A inhibitory activity of quercetin from Calluna vulgaris Hull

      Saaby, Lasse, Jäger, A. K. & Rasmussen, H. B., 2008.

      Research output: Contribution to conference › Poster › Research

    15. Published

      MAO-A inhibitory activity of quercetin from Calluna vulgaris (L.) Hull

      Saaby, Lasse, Rasmussen, H. B. & Jäger, A. K., 2009, In: Journal of Ethnopharmacology. 121, 1, p. 178-181

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Isolation of immunomodulatory triterpene acids from a standardized rose hip powder (Rosa canina L.)

      Saaby, Lasse, Jäger, A. K., Moesby, L., Hansen, E. W. & Christensen, Søren Brøgger, Feb 2011, In: Phytotherapy Research. 25, 2, p. 195-201

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Insight Into the Anti-staphylococcal Activity of JBC 1847 at Sub-Inhibitory Concentration

      Ronco, T., Kappel, L. H., Aragao, M. F., Biagi, N., Svenningsen, Søren Wedel, Christensen, Jørn Bolstad, Permin, A., Saaby, Lasse, Holmstrøm, K., Klitgaard, J. K., Sabat, A. J., Akkerboom, V., Monaco, M., Tinelli, M., Friedrich, A. W., Jana, B. & Olsen, Rikke Heidemann, 2022, In: Frontiers in Microbiology. 12, 786173.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      IPEC-J2 rMdr1a, a New Cell Line with Functional Expression of Rat P-glycoprotein Encoded by Rat Mdr1a for Drug Screening Purposes

      Saaby, Lasse, Trasborg, J., Rasmussen, M. A., Holst, B. & Larsen, Birger Brodin, 17 Jul 2020, In: Pharmaceutics. 12, 7, 17 p., 673.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      IPEC-J2 MDR1, a Novel High-Resistance Cell Line with Functional Expression of Human P-glycoprotein (ABCB1) for Drug Screening Studies

      Saaby, Lasse, Helms, H. C. C. & Larsen, Birger Brodin, 1 Feb 2016, In: Molecular Pharmaceutics. 13, 2, p. 640-52 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Hydrolysed pea proteins mitigate in vitro wheat starch digiestibility

      López-Barón , N., Sagnelli, D., Blennow, Andreas, Holse, M., Gao, J., Saaby, Lasse, Mullertz, Anette , Jespersen, Birthe P Møller & Vasanthan, T., Jun 2018, In: Food Hydrocolloids. 79, p. 117-126 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Human induced pluripotent stem cells (BIONi010-C) generate tight cell monolayers with blood-brain barrier traits and functional expression of large neutral amino acid transporter 1 (SLC7A5)

      Goldeman, C., Andersen, M., Al-Robai, A., Buchholtz, T., Svane, Nana Isabella, Ozgür, Burak, Holst, B., Shusta, E., Hall, Vanessa Jane, Saaby, Lasse, Hyttel, P. & Larsen, Birger Brodin, 2021, In: European Journal of Pharmaceutical Sciences. 156, 14 p., 105577.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Gluten Degradation, Pharmacokinetics, Safety, and Tolerability of TAK-062, an Engineered Enzyme to Treat Celiac Disease

      Pultz, I. S., Hill, M., Vitanza, J. M., Wolf, C., Saaby, Lasse, Liu, T., Winkle, P. & Leffler, D. A., Jul 2021, In: Gastroenterology. 161, 1, p. 81-93.e3

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Generation of an iPSC-line (BIONi010C-48) with restored P-glycoprotein functionality following transfection with the human MDR1 gene in the AAVS1 locus

      Nielsen, A. K. R., Lilieholm-Røngren, L., Schmid, B., Holst, B., Larsen, Birger Brodin & Saaby, Lasse, 2024, In: Stem Cell Research. 76, 5 p., 103348.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Flavonoids and the CNS

      Jäger, A. K. & Saaby, Lasse, 10 Feb 2011, In: Molecules. 16, 2, p. 1471-1485

      Research output: Contribution to journal › Review › Research › peer-review

    25. Published

      Evaluation of immunomodulating and anti-inflammatory effects of a herbal remedy based on rose hip powder (Rosa canina L.)

      Saaby, Lasse, 2011, København: Det Farmaceutiske Fakultet. 130 p.

      Research output: Book/Report › Ph.D. thesis › Research

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