Lasse Saaby
Affiliated Associate Professor, Guest Researcher
- Published
iP-gp , a novel cell line with tight barrier function and expression of human P-glycoprotein (ABCB1) for drug screening
Larsen, Birger Brodin, Ozgür, Burak & Saaby, Lasse, 23 May 2017.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Ubiquitous plant compounds disturb cell-based assays
Saaby, Lasse & Jäger, A. K., 1 Sep 2011, In: Journal of Ethnopharmacology. 137, 1, p. 942-943Research output: Contribution to journal › Comment/debate › Research › peer-review
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Triterpene Acids from Rose Hip Powder Inhibit Self-antigen- and LPS-induced Cytokine Production and CD4(+) T-cell Proliferation in Human Mononuclear Cell Cultures
Saaby, Lasse & Nielsen, Claus Henrik, Aug 2012, In: Phytotherapy Research. 26, 8, p. 1142-1147 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The putative proton-coupled organic cation antiporter is involved in uptake of triptans into human brain capillary endothelial cells
Svane, Nana Isabella, Pedersen, Alberte Bay Villekjær, Rodenberg, A., Ozgür, Burak, Saaby, Lasse, Bundgaard, C., Kristensen, Mie, Tfelt-Hansen, P. & Larsen, Birger Brodin, 2024, In: Fluids and Barriers of the CNS. 21, 19 p., 39.Research output: Contribution to journal › Journal article › Research › peer-review
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The putative P-gp inhibitor telmisartan does not affect the transcellular permeability and cellular uptake of the calcium channel antagonist verapamil in the P-glycoprotein expressing cell line MDCK II MDR1
Saaby, Lasse, Tfelt-Hansen, P. & Larsen, Birger Brodin, 11 Jun 2015, In: Pharmacology Research & Perspectives. 3, 4, p. 1-9 9 p., e00151.Research output: Contribution to journal › Journal article › Research › peer-review
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The iP-gp cell model is an improved tool for predicting the in vivo relevance of P-gp mediated efflux at the blood-brain barrier
Ozgür, Burak, Saaby, Lasse, Eneberg, E., Langthaler, K., Jacobsen, A., Janfelt, Christian, Badolo, L., Montanari, D. & Larsen, Birger Brodin, 22 Jun 2018.Research output: Contribution to conference › Poster › Research › peer-review
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The Pyrazolo[3,4-d]pyrimidine Derivative, SCO-201, Reverses Multidrug Resistance Mediated by ABCG2/BCRP
Ambjørner, S. E. B., Wiese, M., Köhler, S. C., Svindt, J., Lund, X. L., Gajhede, Michael, Saaby, Lasse, Larsen, Birger Brodin, Rump, S., Weigt, H., Brünner, N. & Stenvang, Jan, 4 Mar 2020, In: Cells. 9, 3, 22 p., 613.Research output: Contribution to journal › Journal article › Research › peer-review
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THE POSSIBLE EFFECT OF TELMISARTAN ON THE BLOOD-BRAIN BARRIER TRANSPORT OF VERAPAMIL.
Saaby, Lasse, Tfelt-Hansen, P. & Larsen, Birger Brodin, 18 Sep 2014. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Survival of Lactobacillus acidophilus NCFM® and Bifidobacterium lactis HN019 encapsulated in chocolate during in vitro simulated passage of the upper gastrointestinal tract
Klindt-Toldam, S., Larsen, S. K., Saaby, Lasse, Olsen, L. R., Svenstrup, G., Mullertz, Anette , Knoechel, Susanne, Heimdal, H., Nielsen, Dennis Sandris & Zielińska, D., 2016, In: Lebensmittel - Wissenschaft und Technologie. 74, p. 404-410 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Screening novel CNS drug candidates for P-glycoprotein interactions using the cell line iP-gp: In vitro efflux ratios from iP-gp and MDCK-MDR1 monolayers compared to brain distribution data from mice
Ozgür, Burak, Saaby, Lasse, Janfelt, Christian, Langthaler, K., Eneberg, E., Jacobsen, A., Badolo, L., Montanari, D. & Larsen, Birger Brodin, 2021, In: European Journal of Pharmaceutics and Biopharmaceutics. 169, p. 211-219Research output: Contribution to journal › Journal article › Research › peer-review
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SEDDS for intestinal absorption of insulin: Application of Caco-2 and Caco-2/HT29 co-culture monolayers and intra-jejunal instillation in rats
Liu, J., Werner, U., Funke, M., Besenius, M., Saaby, Lasse, Fano, M., Mu, Huiling & Mullertz, Anette , 5 Apr 2019, In: International Journal of Pharmaceutics. 560, p. 377-384Research output: Contribution to journal › Journal article › Research › peer-review
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Physical and barrier changes in gastrointestinal mucus induced by the permeation enhancer sodium 8-[(2-hydroxybenzoyl)amino]octanoate (SNAC)
Mortensen, Janni Støvring, Bohr, S. S. R., Rønholt, Stine, Hatzakis, Nikos, Saaby, Lasse & Nielsen, Hanne Mørck, 2022, In: Journal of Controlled Release. 352, p. 163-178 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Neonatal intestinal mucus barrier changes in response to maturity, inflammation, and sodium decanoate supplementation
Mortensen, Janni Støvring, Bohr, S. S. R., Krog, Lasse Skjoldborg, Bøtker, Johan Peter, Kapousidou, V., Saaby, Lasse, Hatzakis, Nikos, Nielsen, Hanne Mørck, Nguyen, Duc Ninh & Rønholt, Stine, 2024, In: Scientific Reports. 14, 1, 17 p., 7665.Research output: Contribution to journal › Journal article › Research › peer-review
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MAO-A inhibitory activity of quercetin from Calluna vulgaris Hull
Saaby, Lasse, Jäger, A. K. & Rasmussen, H. B., 2008.Research output: Contribution to conference › Poster › Research
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MAO-A inhibitory activity of quercetin from Calluna vulgaris (L.) Hull
Saaby, Lasse, Rasmussen, H. B. & Jäger, A. K., 2009, In: Journal of Ethnopharmacology. 121, 1, p. 178-181Research output: Contribution to journal › Journal article › Research › peer-review
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Isolation of immunomodulatory triterpene acids from a standardized rose hip powder (Rosa canina L.)
Saaby, Lasse, Jäger, A. K., Moesby, L., Hansen, E. W. & Christensen, Søren Brøgger, Feb 2011, In: Phytotherapy Research. 25, 2, p. 195-201Research output: Contribution to journal › Journal article › Research › peer-review
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Insight Into the Anti-staphylococcal Activity of JBC 1847 at Sub-Inhibitory Concentration
Ronco, T., Kappel, L. H., Aragao, M. F., Biagi, N., Svenningsen, Søren Wedel, Christensen, Jørn Bolstad, Permin, A., Saaby, Lasse, Holmstrøm, K., Klitgaard, J. K., Sabat, A. J., Akkerboom, V., Monaco, M., Tinelli, M., Friedrich, A. W., Jana, B. & Olsen, Rikke Heidemann, 2022, In: Frontiers in Microbiology. 12, 786173.Research output: Contribution to journal › Journal article › Research › peer-review
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IPEC-J2 rMdr1a, a New Cell Line with Functional Expression of Rat P-glycoprotein Encoded by Rat Mdr1a for Drug Screening Purposes
Saaby, Lasse, Trasborg, J., Rasmussen, M. A., Holst, B. & Larsen, Birger Brodin, 17 Jul 2020, In: Pharmaceutics. 12, 7, 17 p., 673.Research output: Contribution to journal › Journal article › Research › peer-review
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IPEC-J2 MDR1, a Novel High-Resistance Cell Line with Functional Expression of Human P-glycoprotein (ABCB1) for Drug Screening Studies
Saaby, Lasse, Helms, H. C. C. & Larsen, Birger Brodin, 1 Feb 2016, In: Molecular Pharmaceutics. 13, 2, p. 640-52 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Hydrolysed pea proteins mitigate in vitro wheat starch digiestibility
López-Barón , N., Sagnelli, D., Blennow, Andreas, Holse, M., Gao, J., Saaby, Lasse, Mullertz, Anette , Jespersen, Birthe P Møller & Vasanthan, T., Jun 2018, In: Food Hydrocolloids. 79, p. 117-126 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Human induced pluripotent stem cells (BIONi010-C) generate tight cell monolayers with blood-brain barrier traits and functional expression of large neutral amino acid transporter 1 (SLC7A5)
Goldeman, C., Andersen, M., Al-Robai, A., Buchholtz, T., Svane, Nana Isabella, Ozgür, Burak, Holst, B., Shusta, E., Hall, Vanessa Jane, Saaby, Lasse, Hyttel, P. & Larsen, Birger Brodin, 2021, In: European Journal of Pharmaceutical Sciences. 156, 14 p., 105577.Research output: Contribution to journal › Journal article › Research › peer-review
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Gluten Degradation, Pharmacokinetics, Safety, and Tolerability of TAK-062, an Engineered Enzyme to Treat Celiac Disease
Pultz, I. S., Hill, M., Vitanza, J. M., Wolf, C., Saaby, Lasse, Liu, T., Winkle, P. & Leffler, D. A., Jul 2021, In: Gastroenterology. 161, 1, p. 81-93.e3Research output: Contribution to journal › Journal article › Research › peer-review
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Generation of an iPSC-line (BIONi010C-48) with restored P-glycoprotein functionality following transfection with the human MDR1 gene in the AAVS1 locus
Nielsen, A. K. R., Lilieholm-Røngren, L., Schmid, B., Holst, B., Larsen, Birger Brodin & Saaby, Lasse, 2024, In: Stem Cell Research. 76, 5 p., 103348.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Flavonoids and the CNS
Jäger, A. K. & Saaby, Lasse, 10 Feb 2011, In: Molecules. 16, 2, p. 1471-1485Research output: Contribution to journal › Review › Research › peer-review
- Published
Evaluation of immunomodulating and anti-inflammatory effects of a herbal remedy based on rose hip powder (Rosa canina L.)
Saaby, Lasse, 2011, København: Det Farmaceutiske Fakultet. 130 p.Research output: Book/Report › Ph.D. thesis › Research
ID: 4863000
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Data demonstrating the challenges of determining the kinetic parameters of P-gp mediated transport of low-water soluble substrates
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
176
downloads
The Pyrazolo[3,4-d]pyrimidine Derivative, SCO-201, Reverses Multidrug Resistance Mediated by ABCG2/BCRP
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
68
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A novel derivative of thioridazine shows low toxicity and efficient activity against gram‐positive pathogens
Research output: Contribution to journal › Journal article › Research › peer-review
Published