Hanne Mørck Nielsen

Hanne Mørck Nielsen

Professor

ORCID: 0000-0002-7285-9100

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  1. Published

    The surface charge of liposomal adjuvants is decisive for their interactions with the Calu-3 and A549 airway epithelial cell culture models

    Ingvarsson, P. T., Rasmussen, I. S., Viaene, M., Irlik, P. J., Nielsen, Hanne Mørck & Foged, Camilla, Aug 2014, In: European Journal of Pharmaceutics and Biopharmaceutics. 87, 3, p. 480-8 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Engineering of an Inhalable DDA/TDB Liposomal Adjuvant: A Quality-by-Design Approach Towards Optimization of the Spray Drying Process

    Ingvarsson, P. T., Yang, Mingshi, Mulvad, H., Nielsen, Hanne Mørck, Rantanen, Jukka & Foged, Camilla, 22 Jun 2013, In: Pharmaceutical Research. 30, 11, p. 2772-2784

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Stabilization of liposomes during drying

    Ingvarsson, P. Þ., Yang, M., Nielsen, Hanne Mørck, Rantanen, J. T. & Foged, C., 2011, In: Expert Opinion on Drug Delivery. 8, 3, p. 375-388

    Research output: Contribution to journal › Review › Research

  4. Published

    Stabilization of liposomes during drying

    Ingvarsson, P. Þ., Yang, Mingshi, Nielsen, Hanne Mørck, Rantanen, Jukka & Foged, Camilla, 2011, In: Expert Opinion on Drug Delivery. 8, 3, p. 375-388

    Research output: Contribution to journal › Review › Research

  5. Published

    Tailoring Cytotoxicity of Antimicrobial Peptidomimetics with High Activity against Multidrug-Resistant Escherichia coli

    Jahnsen, R. D., Sandberg-Schaal, A., Vissing, K. J., Nielsen, Hanne Mørck, Frimodt-Møller, N. & Franzyk, Henrik, 20 Mar 2014, In: Journal of Medicinal Chemistry. 57, 7, p. 2864-2873

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    End Group Modification: Efficient Tool for Improving Activity of Antimicrobial Peptide Analogues towards Gram-Positive Bacteria

    Jahnsen, R. O., Sandberg-Schaal, A., Frimodt-Møller, N., Nielsen, Hanne Mørck & Franzyk, Henrik, 23 Jan 2015, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 95, Part A, p. 40–46 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Lipidoid-Polymer Hybrid Nanoparticles Loaded with TNF siRNA Suppress Inflammation after Intra-articular Administration in a Murine Experimental Arthritis Model

    Jansen, M. A. A., Klausen, L. H., Thanki, K., Lyngsø, J., Skov Pedersen, J., Franzyk, Henrik, Nielsen, Hanne Mørck, van Eden, W., Dong, M., Broere, F., Foged, Camilla & Zeng, X., 2019, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 142, p. 38-48

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Spray drying of siRNA-containing PLGA nanoparticles intended for inhalation

    Jensen, D. M. K., Cun, D., Maltesen, M. J., Frøkjær, Sven, Nielsen, Hanne Mørck & Foged, Camilla, 2010, In: Journal of Controlled Release. 142, p. 138-145

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Design of an inhalable dry powder formulation of DOTAP-modified PLGA nanoparticles loaded with siRNA

    Jensen, D. M. K., Jensen, L. B., Koocheki, S., Cun, D., Nielsen, Hanne Mørck, Foged, Camilla & Bengtson, L., 2012, In: Journal of Controlled Release. 157, 1, p. 141-148

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Spray drying of siRNA-containing PLGA nanoparticles intended for inhalation

    Jensen, D. M. K., Cun, D., Maltesen, M. J., Frøkjær, S., Nielsen, Hanne Mørck & Foged, C., 2010, In: Journal of Controlled Release. 142, p. 138-145

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Molecular Characterization of the Interaction between siRNA and PAMAM G7 Dendrimers by SAXS, ITC, and Molecular Dynamics Simulations

    Jensen, L. B., Mortensen, Kell, Pavan, G. M., Kasimova, M. R., Jensen, D. K., Gadzhyeva, V., Nielsen, Hanne Mørck & Foged, Camilla, Dec 2010, In: Biomacromolecules. 11, 12, p. 3571-3577

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Molecular characterization of the interaction between siRNA and PAMAM G7 dendrimers by SAXS, ITC, and molecular dynamics simultations

    Jensen, L. B., Mortensen, K., Pavan, G. M., Kasimova, M. R., Jensen, D. K., Gadzhyeva, V., Nielsen, Hanne Mørck & Foged, C., 2010, In: Biomacromolecules. 11, 12, p. 3571-3577

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Comparison of polymeric siRNA nanocarriers in murine LPS-activated macrophage cell line: Gene silencing, toxicity and off-target gene expression

    Jensen, L. B., Griger, J., Naeye, B., Varkouhi, A. K., Raemdonck, K., Schiffelers, R., Lammers, T., Storm, G., Smedt, S. C. D., Sproat, B. S., Nielsen, Hanne Mørck & Foged, Camilla, 2012, In: Pharmaceutical Research. 29, p. 669-682

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Dendritiske nanostrukturer som transportører af genestisk medicin

    Jensen, L. B., Nielsen, Hanne Mørck & Foged, Camilla, 2008, In: Lægemiddelforskning. p. 13-15

    Research output: Contribution to journal › Journal article › Communication

  15. Influence of skin barrier on in-vitro penetration properties of solid lipid nanoparticles

    Jensen, L. B., Nielsen, Hanne Mørck & Petersson, K., 2010, In: Journal of Pharmacy and Pharmacology. p. 793-794

    Research output: Contribution to journal › Conference abstract in journal › Research

  16. Published

    Elucidating the molecular mechanism of PAMAM-siRNA dendriplex self-assembly: Effect of dendrimer charge density

    Jensen, L. B., Pavan, G. M., Kasimova, M. R., Rutherford, S., Danani, A., Nielsen, Hanne Mørck & Foged, Camilla, 2011, In: International Journal of Pharmaceutics. 416, 2, p. 410-418

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    In vitro penetration properties of solid lipid nanoparticles in intact and barrier-impaired skin

    Jensen, L. B., Petersson, K. & Nielsen, Hanne Mørck, 2011, In: European Journal of Pharmaceutics and Biopharmaceutics. 79, 1, p. 68-75

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Influence of skin barrier on in-vitro penetration properties of solid lipid nanoparticles

    Jensen, L. B., Nielsen, Hanne Mørck & Petersson, K., 2010, In: Journal of Pharmacy and Pharmacology. p. 793-794

    Research output: Contribution to journal › Conference abstract in journal › Research

  19. Dendritiske nanostrukturer som transportører af genestisk medicin

    Jensen, L. B., Nielsen, Hanne Mørck & Foged, C., 2008, In: Lægemiddelforskning. p. 13-15

    Research output: Contribution to journal › Journal article › Communication

  20. Published

    Molecular characterization of the interaction between siRNA and PAMAM G7 dendrimers by SAXS, ITC, and molecular dynamics simultations

    Jensen, L. B., Mortensen, Kell, Pavan, G. M., Kasimova, M. R., Jensen, D. K., Gadzhyeva, V., Nielsen, Hanne Mørck & Foged, Camilla, 2010, In: Biomacromolecules. 11, 12, p. 3571-3577

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Corticosteroid solubility and lilpid polarity control release from solid lipid nanoparticles

    Jensen, L. B., Magnusson, E., Gunnarsson, L., Vermehren, C., Nielsen, Hanne Mørck & Petersson, K., 2010, In: Internation Journal of Pharmaceutics. 390, 1, p. 53-60

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Kan nanopartikler bruges i behandlingen af hudsygdomme?

    Jensen, L. B., Knudsen, N. Ø., Foged, Camilla & Nielsen, Hanne Mørck, 2010, In: Lægemiddelforskning. 2010, p. 10-12

    Research output: Contribution to journal › Journal article › Communication

  23. Kan nanopartikler bruges i behandlingen af hudsygdomme?

    Jensen, L. B., Knudsen, N. Ø., Foged, C. & Nielsen, Hanne Mørck, 2010, In: Lægemiddelforskning. 2010, p. 10-12

    Research output: Contribution to journal › Journal article › Communication

  24. Published

    Delivery of siRNA Complexed with Palmitoylated α-Peptide/β-Peptoid Cell-Penetrating Peptidomimetics: Membrane Interaction and Structural Characterization of a Lipid-Based Nanocarrier System.

    Jing, X., Foged, Camilla, Martin-Bertelsen, Birte, Yaghmur, Anan, Knapp, K. M., Malmsten, M., Franzyk, Henrik & Nielsen, Hanne Mørck, 6 Jun 2016, In: Molecular Pharmaceutics. 13, 6, p. 1739-1749 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Membrane adsorption and binding, cellular uptake and cytotoxicity of cell-penetrating peptidomimetics with α-peptide/β-peptoid backbone: effects of hydrogen bonding and α-chirality in the β-peptoid residues

    Jing, X., Yang, M., Kasimova, M. R., Malmsten, M., Franzyk, Henrik, Jørgensen, Lene, Foged, Camilla & Nielsen, Hanne Mørck, 2012, In: BBA General Subjects. 1818, 11, p. 2660-2668 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Microcalorimetric and spectroscopic studies on the mechanism of interaction between novel peptoids and lipid bilayers - effect of length, charge and N-terminal end group

    Jing, X., Simonsen, A. H., Kasimova, M. R., Franzyk, Henrik, Foged, Camilla & Nielsen, Hanne Mørck, 2010, In: Drug Discovery Today. 15, 23/24, p. 1109

    Research output: Contribution to journal › Conference abstract in journal › Research

  27. Microcalorimetric and spectroscopic studies on the mechanism of interaction between novel peptoids and lipid bilayers - effect of length, charge and N-terminal end group

    Jing, X., Simonsen, A. H., Kasimova, M. R., Franzyk, H., Foged, C. & Nielsen, Hanne Mørck, 2010, In: Drug Discovery Today. 15, 23/24, p. 1109

    Research output: Contribution to journal › Conference abstract in journal › Research

  28. Cellular and intracellular distribution of recombinant activated factor VII in the rat liver

    Johansen, T. S., Nielsen, Hanne Mørck, Christensen, E. I. & Appa, R. S., 2010, In: Thrombosis and Haemostasis. 103, 4, p. 860-862

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    The unsialylated subpopulation of recombinant activated factor VII binds to the asialo-glycoprotein receptor (ASGPR) on primary rat hepatocytes

    Johansen, T. S., Nielsen, Hanne Mørck, Christensen, E. I. & Appa, R. S., 2010, In: Thrombosis and Haemostasis. 104, 6, p. 1166-1173

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. The unsialylated subpopulation of recombinant activated factor VII binds to the asialo-glycoprotein receptor (ASGPR) on primary rat hepatocytes

    Johansen, T. S., Nielsen, Hanne Mørck, Christensen, E. I. & Appa, R. S., 2010, In: Thrombosis and Haemostasis. 104, 6, p. 1166-1173

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. In vivo clearance and metabolism of recombinant activated factor VII (rFVIIa) and its complexes with plasma protease inhibitors in the liver

    Johansen, T. S., Appa, R. S., Christensen, E. I., Ioannou, Y. A., Krogh, T. N., Karpf, D. M. & Nielsen, Hanne Mørck, 2011, In: Thrombosis Research. 127, 4, p. 356-362

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    In vivo clearance and metabolism of recombinant activated factor VII (rFVIIa) and its complexes with plasma protease inhibitors in the liver

    Johansen, T. S., Appa, R. S., Christensen, E. I., Ioannou, Y. A., Krogh, T. N., Karpf, D. M. & Nielsen, Hanne Mørck, 2011, In: Thrombosis Research. 127, 4, p. 356-362

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Cellular and intracellular distribution of recombinant activated factor VII in the rat liver

    Johansen, T. S., Nielsen, Hanne Mørck, Christensen, E. I. & Appa, R. S., 2010, In: Thrombosis and Haemostasis. 103, 4, p. 860-862

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Design of a self-unfolding delivery concept for oral administration of macromolecules

    Jørgensen, J. R., Thamdrup, L. H. E., Kamguyan, K., Nielsen, L. H., Nielsen, Hanne Mørck, Boisen, A., Rades, Thomas & Mullertz, Anette , 2021, In: Journal of Controlled Release. 329, p. 948-954

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    In Vitro, Ex Vivo and In Vivo Evaluation of Microcontainers for Oral Delivery of Insulin

    Jørgensen, J. R., Yu, F., Ramakrishnan, V., Nielsen, L. H., Nielsen, Hanne Mørck, Boisen, A., Rades, Thomas & Mullertz, Anette , 7 Jan 2020, In: Pharmaceutics. 12, 1, 14 p., 48.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Delivery technologies for biopharmaceuticals: Peptides, proteins, nucleic acids and vaccines

    Jørgensen, Lene & Nielsen, Hanne Mørck, 2009, Wiley. 413 p.

    Research output: Book/Report › Book › Research › peer-review

  37. Published

    Issues in development of biodrug delivery systems

    Jørgensen, Lene, Frøkjær, Sven & Nielsen, Hanne Mørck, 2010, Biodrug delivery systems: fundamentals, applications and clinical development. Morishita, M. & Park, K. (eds.). New York: Informa Healthcare, p. 13-25

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  38. Published

    Biotechnology-based pharmaceuticals

    Jørgensen, Lene, Nielsen, Hanne Mørck & Frøkjær, Sven, 2009, Modern pharmaceutics: applications and advances. Florence, A. T. & Siepmann, J. (eds.). 5 ed. New York: Informa Healthcare, Vol. 2. p. 259-293 (Drugs and the Pharmaceutical Sciences, Vol. 188).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  39. Biotechnology-based pharmaceuticals

    Jørgensen, L., Nielsen, Hanne Mørck & Frøkjær, S., 2009, Modern pharmaceutics: applications and advances. Florence, A. T. & Siepmann, J. (eds.). 5 ed. New York: Informa Healthcare, Vol. 2. p. 259-293 (Drugs and the Pharmaceutical Sciences, Vol. 188).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  40. Published

    Issues in Development of Biodrug Delivery Systems

    Jørgensen, Lene, Frøkjær, Sven & Nielsen, Hanne Mørck, 2010, Biodrug Delivery Systems: Fundamentals, Applications and Clinical Development. Morishita, M. & Park, K. (eds.). 1 ed. Informa Healthcare, p. 13-25

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  41. Delivery technologies for biopharmaceuticals: Peptides, proteins, nucleic acids and vaccines

    Jørgensen, L. & Nielsen, Hanne Mørck, 2009, Wiley. 413 p.

    Research output: Book/Report › Book › Research › peer-review

  42. Published

    Electrospun α-lactalbumin nanofibers for site-specific and fast-onset delivery of nicotine in the oral cavity: an in vitro, ex vivo and tissue spatial distribution study

    Kalouta, Kleopatra, Stie, Mai Bay, Janfelt, Christian, Chronakis, I. S., Jacobsen, Jette, Nielsen, Hanne Mørck & Foderà, Vito, 2020, In: Molecular Pharmaceutics. 17, 11, p. 4189-4200

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    On the temperature dependence of complex formation between chitosan and proteins

    Kasimova, M. R., Valázquez-Campoy, A. & Nielsen, Hanne Mørck, 2011, In: Biomacromolecules. 12, 7, p. 2534-2543

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. On the temperature dependence of complex formation between chitosan and proteins

    Kasimova, M. R., Valázquez-Campoy, A. & Nielsen, Hanne Mørck, 2011, In: Biomacromolecules. 12, 7, p. 2534-2543

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Inhalable Antimicrobials for Treatment of Bacterial Biofilm-Associated Sinusitis in Cystic Fibrosis Patients: Challenges and Drug Delivery Approaches

    Klodzinska, S. N., Priemel, P. A., Rades, Thomas & Nielsen, Hanne Mørck, 9 Oct 2016, In: International Journal of Molecular Sciences . 17, 10, 19 p., 1688.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Combining diagnostic methods for antimicrobial susceptibility testing – A comparative approach

    Klodzinska, S. N., Priemel, P. A., Rades, Thomas & Nielsen, Hanne Mørck, Jan 2018, In: Journal of Microbiological Methods. 144, p. 177-185

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Cellular effects and delivery propensity of penetratin is influenced by conjugation to parathyroid hormone fragment 1-34 in synergy with pH

    Kristensen, Mie, Nielsen, L. H., Zor, K., Boisen, A., Christensen, M. V., Berthelsen, J. & Nielsen, Hanne Mørck, 2018, In: Bioconjugate Chemistry. 29, 2, p. 371-381

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Penetratin-Mediated Transepithelial Insulin Permeation: Importance of Cationic Residues and pH for Complexation and Permeation

    Kristensen, Mie, Franzyk, Henrik, Klausen, M. T., Iversen, A., Bahnsen, J. S., Skyggebjerg, R. B., Foderà, Vito & Nielsen, Hanne Mørck, 2015, In: A A P S Journal. 17, 5, p. 1200-1209 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Reversible tight junction modulation using an enterotoxin-derived peptide as enhancer for delivery of biopharmaceuticals across biobarriers

    Kristensen, M. & Nielsen, Hanne Mørck, 2015.

    Research output: Contribution to conference › Poster › Research › peer-review

  50. Published

    Applications and Challenges for Use of Cell-Penetrating Peptides as Delivery Vectors for Peptide and Protein Cargos

    Kristensen, Mie, Birch, D. & Nielsen, Hanne Mørck, 30 Jan 2016, In: International Journal of Molecular Sciences . 17, 2, p. 1-17 17 p., 185.

    Research output: Contribution to journal › Review › Research › peer-review

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