Design of a self-unfolding delivery concept for oral administration of macromolecules

Research output: Contribution to journalJournal articlepeer-review

Documents

  • Fulltext

    Accepted author manuscript, 664 KB, PDF document

Delivering macromolecular drugs, e.g. peptides, to the systemic circulation by oral administration is challenging due to their degradation in the gastrointestinal tract and low transmucosal permeation. In this study, the concept of an oral delivery device utilizing an elastomeric material is presented with the potential of increasing the absorption of peptides, e.g. insulin. Absorption enhancement in the intestine is proposed as a result of self-unfolding of a polydimethylsiloxane foil upon release from enteric coated capsules. A pH-sensitive polymer coating prevents capsule disintegration until arrival in the small intestine where complete unfolding of the elastomeric foil ensures close contact with the intestinal mucosa. Foils with close-packed hexagonal compartments for optimal drug loading are produced by casting against a deep-etched silicon master. Complete unfolding of the foil upon capsule disintegration is verified in vitro and the insulin release profile of the final delivery device confirms insulin protection at gastric pH. In vivo performance is evaluated with the outcome of quantifiable plasma insulin concentrations in all rats receiving duodenal administration of the novel delivery device. By taking advantage of elastomeric material properties for drug delivery, this approach might serve as inspiration for further development of commercially viable biocompatible devices for oral delivery of macromolecules.

Original languageEnglish
JournalJournal of Controlled Release
Volume329
Pages (from-to)948-954
ISSN0168-3659
DOIs
Publication statusPublished - 2021

    Research areas

  • Delivery devices, Elastomers, Oral insulin, Permeation enhancers, Polydimethylsiloxane, Protease inhibitors

Number of downloads are based on statistics from Google Scholar and www.ku.dk


No data available

ID: 257326597