Birger Brodin Larsen
Professor
CNS Drug Delivery and Barrier Modelling
Universitetsparken 2
2100 København Ø
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Nitric oxide, KATP channels and endothelin-1 modulate brain pericyte function, vascular tone and neurovascular coupling
Zambach, S. A., Cai, Changsi, Helms, H. C. C., Hald, B. O., Fordsmann, J. C., Nielsen, R. M., wbh615, wbh615, Larsen, Birger Brodin & Lauritzen, Martin, 8 Jun 2020, bioRxiv, 43 p.Research output: Working paper › Preprint › Research
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Precapillary sphincters and pericytes at first-order capillaries as key regulators for brain capillary perfusion
Zambach, S. A., Cai, Changsi, Helms, H. C. C., Hald, B. O., Dong, Y., Fordsmann, J. C., Nielsen, R. M., Hu, J., wbh615, wbh615, Larsen, Birger Brodin & Lauritzen, Martin, 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 26, e2023749118.Research output: Contribution to journal › Journal article › Research › peer-review
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miRNA-27a-3p and miRNA-222-3p as Novel Modulators of Phosphodiesterase 3a (PDE3A) in Cerebral Microvascular Endothelial Cells
Yasmeen, S., Kaur, S., Mirza, A. H., Larsen, Birger Brodin, Pociot, Flemming & Kruuse, Christina Rostrup, Aug 2019, In: Molecular Neurobiology. 56, 8, p. 5304–5314Research output: Contribution to journal › Journal article › Research › peer-review
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In Vitro Blood-Brain Barrier Models-An Overview of Established Models and New Microfluidic Approaches
Wolff, A., Antfolk, M., Larsen, Birger Brodin & Tenje, M., 28 Jan 2015, In: Journal of Pharmaceutical Sciences. 104, 9, p. 2727-2746 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Carbonic anhydrase imhibitors. Transepithelial transport of novel anticancer sulfonamide inhibitors of the cancer-associated isozyme CA IX is dependent on the p.gp efflux transporter
Vullo, D., Steffansen, B., Larsen, Birger Brodin, Supuran, C. T., Scozzafava, A. & Nielsen, C. U., 2006, In: Bioorganic & Medicinal Chemistry Letters. 14, 7, p. 2418-2427Research output: Contribution to journal › Journal article › Research › peer-review
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Transendothelial electrical resistance measurement across the blood–brain barrier: A critical review of methods
Vigh, J. P., Kincses, A., Ozgür, Burak, Walter, F. R., Santa-Maria, A. R., Valkai, S., Vastag, M., Neuhaus, W., Larsen, Birger Brodin, Dér, A. & Deli, M. A., 2021, In: Micromachines. 12, 6, 18 p., 685.Research output: Contribution to journal › Review › Research › peer-review
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Sortilin regulates blood-brain barrier integrity
Toth, A. E., Helms, H. C., Harazin, A., Johnsen, K. B., Goldeman, C., Burkhart, A., Thomsen, M. S., Kempen, P. J., Klepe, A., Lipka, D. V., Møller, P. L., Andresen, T. L., Nyegaard, M., Moos, T., Larsen, Birger Brodin & Nielsen, M. S., 2022, In: The FEBS Journal. 289, 4, p. 1062-1079Research output: Contribution to journal › Journal article › Research › peer-review
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Stroke and Drug Delivery--In Vitro Models of the Ischemic Blood-Brain Barrier
Tornabene, E. & Larsen, Birger Brodin, Feb 2016, In: Journal of Pharmaceutical Sciences. 105, 2, p. 398-405 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of oxygen-glucose deprivation (OGD) on barrier properties and mRNA transcript levels of selected marker proteins in brain endothelial cells/astrocyte co-cultures
Tornabene, E., Helms, H. C. C., Pedersen, Stine Helene Falsig & Larsen, Birger Brodin, 2019, In: PLoS ONE. 14, 8, 20 p., e0221103.Research output: Contribution to journal › Journal article › Research › peer-review
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Prodrugs of purine and pyrimidine analogues for the intestinal di/tri-peptide transporter PepT1: affinity for hPepT1 in Caco-2 cells, drug release in aqueous media and in vitro metabolism
Thomsen, A. E., Friedrichsen, G. M., Sørensen, A. H., Andersen, R., Nielsen, C. U., Larsen, Birger Brodin, Begtrup, M., Frøkjær, Sven & Steffansen, B., 2003, In: Journal of Controlled Release. 86, 2-3, p. 279-92 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Erratum: Prodrugs of purine and pyrimidine analogues for the intestinal di/tri-peptide transporter PepT1: Affinity for hPepT1 in Caco-2 cells, drug release in aqueous media and in vitro metabolism (Journal of Controlled Release (2003) 86 (279-292) PII: S0168365902004133)
Thomsen, A. E., Friedrichsen, G. M., Sørensen, A. H., Andersen, R., Nielsen, C. U., Larsen, Birger Brodin, Begtrup, M., Frøkjær, Sven & Steffansen, B., 7 Mar 2003, In: Journal of Controlled Release. 88, 2Research output: Contribution to journal › Journal article › Research › peer-review
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Identification and Characterization of a Novel Nontranslated Sequence Variant of the Human Intestinal Di-/Tripeptide Transporter, hPEPT1
Søndergaard, H. B., Nielsen, C. U. & Larsen, Birger Brodin, 31 Dec 2012, In: International Journal of Peptides. 2012, 2012, 7 p., 743472.Research output: Contribution to journal › Journal article › Research › peer-review
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hPEPT1 is responsible for uptake and transport of Gly-Sar in the human bronchial airway epithelial cell-line Calu-3
Søndergaard, H. B., Larsen, Birger Brodin & Nielsen, C. U., 2008, In: Pflügers Archiv: European Journal of Physiology. 456, 3, p. 611-622Research output: Contribution to journal › Journal article › Research › peer-review
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Cloning of the pig PEPT2 (pPEPT2) and characterization of the effects of epidermal growth factor (EGF) on pPEPT2-mediated peptide uptake in the renal porcine cell line LLC-PK1
Søndergaard, H. B., Bravo, S. A., Nielsen, C. U., Frøkjær, Sven & Larsen, Birger Brodin, 2008, In: European Journal of Pharmaceutical Sciences. 33, 4-5, p. 332-342Research output: Contribution to journal › Journal article › Research › peer-review
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The putative proton-coupled organic cation antiporter is involved in uptake of triptans into human brain capillary endothelial cells
Svane, Nana Isabella, Pedersen, Alberte Bay Villekjær, Rodenberg, A., Ozgür, Burak, Saaby, Lasse, Bundgaard, C., Kristensen, Mie, Tfelt-Hansen, P. & Larsen, Birger Brodin, 2024, In: Fluids and Barriers of the CNS.Research output: Contribution to journal › Journal article › Research › peer-review
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Calu-3 cells grown under AIC and LCC conditions: implications for dipeptide uptake and transepithelial transport of substances
Stentebjerg-Andersen, A., Notlevesen, I. V., Larsen, Birger Brodin & Nielsen, C. U., 2011, In: European Journal of Pharmaceutics and Biopharmaceutics. 78, 1, p. 19-26Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular biopharmaceutics: Aspects of drug characterisation, drug delivery and dosage form evaluation
Steffansen, B., Larsen, Birger Brodin & Nielsen, C. U., 2010, Pharmaceutical Press. (ULLA Pharmacy Series).Research output: Book/Report › Book › Research › peer-review
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Kinetics of decomposition in aqueous solution
Steffansen, B., Nielsen, C. U. & Larsen, Birger Brodin, 2010, Molecular biopharmaceutics: Aspects of drug characterisation, drug delivery and dosage form evaluation. Steffansen, B., Brodin, B. & Nielsen, C. U. (eds.). Pharmaceutical Press, p. 51-69 (ULLA Pharmacy Series).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Introduction
Steffansen, B., Nielsen, C. U. & Larsen, Birger Brodin, 2010, Molecular biopharmaceutics: Aspects of drug characterisation, drug delivery and dosage from evaluation. Steffansen, B., Brodin, B. & Uhd Nielsen, C. (eds.). London: Pharmaceutical Press, p. 1-4 4 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Membrane Transporters in ADME
Steffansen, B., Nielsen, C. U. & Larsen, Birger Brodin, 2013, Transporters in drug development: discovery, optimization, clinical study and regulation. Steffansen, B. & Sugiyama, Y. (eds.). Springer Publishing Company, Vol. 7. p. 1-22 (AAPS Advances in the Pharmaceutical Sciences Series).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Acid/base properties, solubility and distribution of drug candidates
Steffansen, B., Nielsen, C. U. & Larsen, Birger Brodin, 2010, Molecular Biopharmaceutics: Aspects of drug characterization drug delivery and dosage form evaluation. Pharmaceutical Press, p. 5-31Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Intestinal solute carriers: an overview of trends and strategies for improving oral drug absorption
Steffansen, B., Nielsen, C. U., Larsen, Birger Brodin, Eriksson, A. H., Andersen, R. & Frøkjær, Sven, 2004, In: European Journal of Pharmaceutical Sciences. 21, 1, p. 3-16 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mechanism of decomposition of drug candidates
Steffansen, B., Nielsen, C. U. & Larsen, Birger Brodin, 2010, Molecular Biopharmaceutics: Aspects of drug characterization, drug delivery and dosage form evaluation. Pharmaceutical Press, p. 35-48 13 p. (ULLA Pharmacy Series).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Serotonin transporter protein (SERT) and P-glycoprotein (P-gp) binding activity of montanine and coccinine from three species of Haemanthus L. (Amaryllidaceae)
Stafford, G. I., Birer, C., Larsen, Birger Brodin, Christensen, Søren Brøgger, Eriksson, A. H., Jäger, A. & Rønsted, Nina, Sep 2013, In: South African Journal of Botany. 88, p. 101-106 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Bidirectional apical-basal traffic of the cation-independent mannose-6-phosphate receptor in brain endothelial cells
Siupka, P., Hersom, M. N., Lykke-Hartmann, K., Johnsen, K. B., Thomsen, L. B., Andresen, T. L., Moos, T., Abbott, N. J. & Larsen, Birger Brodin, 1 Jan 2017, In: Journal of Cerebral Blood Flow and Metabolism. 37, 7, p. 2598-2613Research output: Contribution to journal › Journal article › Research › peer-review
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VPS10P domain receptor trafficking in brain endothelial cells
Siupka, P., Højland, A., Thomsen, L. B., Lykke-Hartmann, K., Helms, H. C. C., Larsen, Birger Brodin, Moos, T., Madsen, P. S. & Nielsen, M. S., 10 Dec 2014. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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The putative P-gp inhibitor telmisartan does not affect the transcellular permeability and cellular uptake of the calcium channel antagonist verapamil in the P-glycoprotein expressing cell line MDCK II MDR1
Saaby, Lasse, Tfelt-Hansen, P. & Larsen, Birger Brodin, 11 Jun 2015, In: Pharmacology Research & Perspectives. 3, 4, p. 1-9 9 p., e00151.Research output: Contribution to journal › Journal article › Research › peer-review
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A Critical View on In Vitro Analysis of P-glycoprotein (P-gp) Transport Kinetics
Saaby, Lasse & Larsen, Birger Brodin, Sep 2017, In: Journal of Pharmaceutical Sciences. 106, 9, p. 2257-2264 8 p.Research output: Contribution to journal › Review › Research › peer-review
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THE POSSIBLE EFFECT OF TELMISARTAN ON THE BLOOD-BRAIN BARRIER TRANSPORT OF VERAPAMIL.
Saaby, Lasse, Tfelt-Hansen, P. & Larsen, Birger Brodin, 18 Sep 2014. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Substrate-Dependent Inhibition of P-glycoprotein Mediated Efflux Transport of Digoxin
Saaby, L., Ozgür, Burak & Larsen, Birger Brodin, 14 Nov 2017, p. T7089.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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IPEC-J2 rMdr1a, a New Cell Line with Functional Expression of Rat P-glycoprotein Encoded by Rat Mdr1a for Drug Screening Purposes
Saaby, Lasse, Trasborg, J., Rasmussen, M. A., Holst, B. & Larsen, Birger Brodin, 17 Jul 2020, In: Pharmaceutics. 12, 7, 17 p., 673.Research output: Contribution to journal › Journal article › Research › peer-review
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Current status of rational design of prodrugs targeting the intestinal di/tri-peptide transporter hPEPT1 (SLC15A1)
Saaby, Lasse, Nielsen, C. U., Steffansen, B., Larsen, Birger Brodin & Larsen, S. B. L., 2013, In: Journal of Drug Delivery Science and Technology. 23, 4, p. 307–314Research output: Contribution to journal › Journal article › Research › peer-review
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IPEC-J2 MDR1, a Novel High-Resistance Cell Line with Functional Expression of Human P-glycoprotein (ABCB1) for Drug Screening Studies
Saaby, Lasse, Helms, H. C. C. & Larsen, Birger Brodin, 1 Feb 2016, In: Molecular Pharmaceutics. 13, 2, p. 640-52 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Prostaglandin E2 release from the dermis regulates sodium permeability of frog skin epithelium
Rytved, K. A., Larsen, Birger Brodin & Nielsen, R., 1995, In: Acta Physiologica Scandinavica. 153, p. 263-270Research output: Contribution to journal › Journal article › Research › peer-review
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Insulin increases peptide transport capacity in the proximal tubule kidney cell line SKPT0193-Cl.2.
Rquez, B., Nielsen, C. U. & Larsen, Birger Brodin, 2006. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Prostaglandin E2 release from dermis regulates sodium permeability of frog skin epithelium
RYTVED, K. A., Larsen, Birger Brodin & NIELSEN, R., 1 Jan 1995, In: Acta Physiologica Scandinavica. 153, 3, p. 263-270 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular mechanisms underlying potassium transport in an in vitro model of the blood-brain barrier
Pedersen, K. L., Assentoft, M., Helms, H. C. C., Larsen, Birger Brodin & MacAulay, N., 12 May 2014. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Screening novel CNS drug candidates for P-glycoprotein interactions using the cell line iP-gp: In vitro efflux ratios from iP-gp and MDCK-MDR1 monolayers compared to brain distribution data from mice
Ozgür, Burak, Saaby, Lasse, Janfelt, Christian, Langthaler, K., Eneberg, E., Jacobsen, A., Badolo, L., Montanari, D. & Larsen, Birger Brodin, 2021, In: European Journal of Pharmaceutics and Biopharmaceutics. 169, p. 211-219Research output: Contribution to journal › Journal article › Research › peer-review
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Hypoxia increases expression of selected blood–brain barrier transporters GLUT-1, P-gp, SLC7A5 and TFRC, while maintaining barrier integrity, in brain capillary endothelial monolayers
Ozgür, Burak, Helms, H. C. C., Tornabene, E. & Larsen, Birger Brodin, 2022, In: Fluids and Barriers of the CNS. 19, 1, 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Data demonstrating the challenges of determining the kinetic parameters of P-gp mediated transport of low-water soluble substrates
Ozgür, Burak, Saaby, Lasse, Langthaler, K. & Larsen, Birger Brodin, 2018, In: Data in Brief. 16, p. 655-659 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of the IPEC-J2 MDR1 (iP-gp) cell line as a tool for identification of P-gp substrates
Ozgür, Burak, Saaby, Lasse, Langthaler, K. & Larsen, Birger Brodin, 2018, In: European Journal of Pharmaceutical Sciences. 112, p. 112-121 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of an iPSC-based barrier model for blood-brain barrier investigations using the SBAD0201 stem cell line
Ozgür, Burak, Puris, E., Brachner, A., Appelt-Menzel, A., Oerter, S., Balzer, V., Holst, M. R., Christiansen, R. F., Hyldig, K., Buckley, S. T., Kristensen, Mie, Auriola, S., Jensen, A., Fricker, G., Nielsen, M. S., Neuhaus, W. & Larsen, Birger Brodin, 2023, In: Fluids and Barriers of the CNS. 20, 1, 15 p., 96.Research output: Contribution to journal › Journal article › Research › peer-review
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The iP-gp cell model is an improved tool for predicting the in vivo relevance of P-gp mediated efflux at the blood-brain barrier
Ozgür, Burak, Saaby, Lasse, Eneberg, E., Langthaler, K., Jacobsen, A., Janfelt, Christian, Badolo, L., Montanari, D. & Larsen, Birger Brodin, 22 Jun 2018.Research output: Contribution to conference › Poster › Research › peer-review
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Design of prodrugs targeting the intestinal di/tri‐peptide transporter hPEPT1 (SLC15A1
Omkvist, D. H., Nielsen, C. U., Steffansen, B., Larsen, S. B., Olsen, L., Jørgensen, Flemming Steen & Larsen, Birger Brodin, 4 Apr 2014. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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A quantitative structure-activity relationship for translocation of tripeptides via the human proton-coupled peptide transporter, hPEPT1 (SLC15A1)
Omkvist, D. H., Larsen, S. B., Nielsen, C. U., Steffansen, B., Olsen, L., Jørgensen, Flemming Steen & Larsen, Birger Brodin, 2010, In: The AAPS Journal. 12, 3, p. 385-396Research output: Contribution to journal › Journal article › Research › peer-review
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Optimization of a cell-based flourescent probe assay for measuring substrate translocation via the proton-coupled intestinal di/tri-peptide transporter hPEPT1
Omkvist, D. H., Nielsen, C. U., Steffansen, B. & Larsen, Birger Brodin, 2007. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Ibuprofen is an inhibitor of hPEPT1: Implications for drug-drug interactions at the level of drug absorption
Omkvist, D. H., Larsen, Birger Brodin & Nielsen, C. U., Mar 2010. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Ibuprofen is an inhibitor of hPEPT1: Implications for drug-drug interactions at the level of drug absorption
Omkvist, D. H., Larsen, Birger Brodin & Nielsen, C. U., 2010.Research output: Contribution to conference › Poster › Research
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Affinity and translocation relationships via hPEPT1 of H-Xaa-Ser-OH dipeptides: evaluation of H-Phe-Ser-OH as a pro-moiety for ibuprofen and benzoic acid prodrugs
Omkvist, D. H., Trangbæk, D. J., Mildon, J., Paine, J. S., Larsen, Birger Brodin, Begtrup, M. & Nielsen, C. U., 2011, In: European Journal of Pharmaceutics and Biopharmaceutics. 77, 2, p. 327-331Research output: Contribution to journal › Journal article › Research › peer-review
ID: 1299175
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Design of prodrugs targeting the intestinal di/tri‐peptide transporter hPEPT1 (SLC15A1
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A bovine in vitro blood-brain barrier model under oxygenglucose deprivation (OGD) condition
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