A capillary-based microfluidic device incorporating optical fibers for flow induced dispersion analysis

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Communication

In this paper, we describe a capillary-based microfluidic device utilizing flow induced dispersion analysis (FIDA) for quantitative characterization of biomarkers. The microfluidic device is fabricated by micromilling technology and has incorporated buried optical fibers for light detection. The angle and distance between the fiber guiding the excitation light source and the fiber collecting fluorescent emission light were optimized to enhance signal-to-noise ratio (SNR) and limit of detection (LOD). The prototype achieves a LOD of 50 nM for the fluorescein indicator by using a low-cost Miniature Fiber Optic Spectrometer. The FIDA-based procedure employing fluorescein as the indicator and human serum albumin (HSA) as the analyte is carried out in the microfluidic device.

Original languageEnglish
Title of host publication8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013
Number of pages4
Publication date2 Sep 2013
Pages1054-1057
Article number6559903
ISBN (Print)9781467363525
DOIs
Publication statusPublished - 2 Sep 2013
Event8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013 - Suzhou, China
Duration: 7 Apr 2013 → 10 Apr 2013

Conference

Conference8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013
LandChina
BySuzhou
Periode07/04/2013 → 10/04/2013
SponsorInstitute of Electrical and Electronics Engineers (IEEE), IEEE Nanotechnology Council (NTC), Peking University, Soochow University, Chinese Academy of Sciences

    Research areas

  • flow induced dispersion analysis, microfluidics, optical fibers

ID: 202480321