Kasper Dyrberg Rand

Kasper Dyrberg Rand

Professor

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    ORCID: 0000-0002-6337-5489

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    1. Published

      A Poly-ADP-Ribose Trigger Releases the Auto-Inhibition of a Chromatin Remodeling Oncogene

      Singh, H. R., Nardozza, A. P., Möller, I. R., Knobloch, G., Kistemaker, H. A. V., Hassler, M., Harrer, N., Blessing, C., Eustermann, S., Kotthoff, C., Huet, S., Mueller-Planitz, F., Filippov, D. V., Timinszky, G., Rand, Kasper Dyrberg & Ladurner, A. G., 7 Dec 2017, In: Molecular Cell. 68, 5, p. 860-871.e7

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      A Two-pronged Binding Mechanism of IgG to the Neonatal Fc Receptor Controls Complex Stability and IgG Serum Half-life

      Jensen, P. F., Schoch, A., Larraillet, V., Hilger, M., Schlothauer, T., Emrich, T. & Rand, Kasper Dyrberg, Mar 2017, In: Molecular and Cellular Proteomics. 16, 3, p. 451-456 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. A combined structural dynamics approach identifies a putative switch in factor VIIa employed by tissue factor to initiate blood coagulation

      Olsen, O. H., Rand, Kasper Dyrberg, Østergaard, H. & Persson, E., 2007, In: Protein Science. 16, 4, p. 671-82 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      A conformational investigation of propeptide binding to the integral membrane protein γ-glutamyl carboxylase using nanodisc hydrogen exchange mass spectrometry

      Parker, C. H., Morgan, C. R., Rand, Kasper Dyrberg, Engen, J. R., Jorgenson, J. W. & Stafford, D. W., 11 Mar 2014, In: Biochemistry. 53, 9, p. 1511-20 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      A novel sensitive sheathless CE-MS device for peptide and protein analysis

      Nguyen, T. T. T. N., Petersen, Nickolaj J. & Rand, Kasper Dyrberg, 8 Jun 2016. 1 p.

      Research output: Contribution to conference › Conference abstract for conference › Research

    6. Published

      A post-translational modification of human Norovirus capsid protein attenuates glycan binding

      Mallagaray, A., Creutznacher, R., Dülfer, J., Mayer, P. H. O., Grimm, L. L., Orduña, J. M., Trabjerg, Esben, Stehle, T., Rand, Kasper Dyrberg, Blaum, B. S., Uetrecht, C. & Peters, T., 21 Mar 2019, In: Nature Communications. 10, 1, 14 p., 1320.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      A simple sheathless CE-MS interface with a sub-micrometer electrical contact fracture for sensitive analysis of peptide and protein samples

      Nguyen, T. T. T. N., Petersen, Nickolaj J. & Rand, Kasper Dyrberg, 2016, In: Analytica Chimica Acta. 936, p. 157–167 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Allosteric activation of coagulation factor VIIa visualized by hydrogen exchange

      Rand, Kasper Dyrberg, Jørgensen, T., Olsen, Ole, Persson, E., Jensen, O., Stennicke, H. R. & Andersen, M., 2006, In: Journal of Biological Chemistry. 281, 32, p. 23018-24 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      An intact C-terminal end of albumin is required for its long half-life in humans

      Nilsen, J., Trabjerg, Esben, Grevys, A., Azevedo, C., Brennan, S. O., Stensland, M., Wilson, J., Sand, K. M. K., Bern, M., Dalhus, B., Roopenian, D. C., Sandlie, I., Rand, Kasper Dyrberg & Andersen, J. T., 20 Apr 2020, In: Communications Biology. 3, 1, 11 p., 181.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      An intact C-terminal end of albumin is required for long serum half-life

      Nilsen, J., Trabjerg, E., Grevys, A., Azevedo, C., Brennan, S. O., Stensland, M., Wilson, J., Sand, K. M. K., Bern, M., Dalhus, B., Roopenian, D. C., Sandlie, I., Rand, Kasper Dyrberg & Andersen, J. T., Dec 2019, p. 19. 1 p.

      Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

    11. Published

      Analytical Techniques in the Pharmaceutical Sciences

      Leurs, U., Mistarz, U. H. & Rand, Kasper Dyrberg, 2016, Analytical Techniques in the Pharmaceutical Sciences. Müllertz, A., Perrie, Y. & Rades, T. (eds.). Springer Publishing Company, p. 253-289 36 p. (Advances in Delivery Science and Technology).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    12. Antibody mechanics on a membrane-bound HIV segment essential for GP41-targeted viral neutralization

      Kim, M., Sun, Z. J., Rand, Kasper Dyrberg, Shi, X., Song, L., Cheng, Y., Fahmy, A. F., Majumdar, S., Ofek, G., Yang, Y., Kwong, P. D., Wang, J., Engen, J. R., Wagner, G. & Reinherz, E. L., 2011, In: Nature Structural and Molecular Biology. 18, 11, p. 1235-43 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Back Cover: Mapping the Interactions of Selective Biochemical Probes of Antibody Conformation by Hydrogen-Deuterium Exchange Mass Spectrometry (ChemBioChem 11/2017)

      Leurs, U., Beck, H., Bonnington, L., Lindner, I., Pol, E. & Rand, Kasper Dyrberg, 1 Jun 2017, In: ChemBioChem.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Benzisothiazolinone derivatives as potent allosteric monoacylglycerol lipase inhibitors that functionally mimic sulfenylation of regulatory cysteines

      Castelli, R., Scalvini, L., Vacondio, F., Lodola, A., Anselmi, M., Vezzosi, S., Carmi, C., Bassi, M., Ferlenghi, F., Rivara, S., Möller, I. R., Rand, K. D., Daglian, J., Wei, D., Dotsey, E. Y., Ahmed, F., Jung, K-M., Stella, N., Singh, S., Mor, M. & 1 others, Piomelli, D., 2020, In: Journal of Medicinal Chemistry. 63, 3, p. 1261-1280

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Circularized and solubility-enhanced MSPs facilitate simple and high-yield production of stable nanodiscs for studies of membrane proteins in solution

      Johansen, Nicolai Tidemand, Tidemand, Frederik Grønbæk, Nguyen, T. T. T. N., Rand, Kasper Dyrberg, Pedersen, Martin Cramer & Arleth, Lise, May 2019, In: F E B S Journal. 286, 9, p. 1734-1751

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Conformational Analysis of Proteins in Highly Concentrated Solutions by Dialysis-Coupled Hydrogen/Deuterium Exchange Mass Spectrometry

      Houde, D., Esmail Nazari, Z., Bou-Assaf, G. M., Weiskopf, A. S. & Rand, Kasper Dyrberg, 9 Feb 2016, In: Journal of the American Society for Mass Spectrometry. 27, 4, p. 669–676 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Conformational analysis of complex protein states by hydrogen/deuterium exchange mass spectrometry (HDX-MS): Challenges and emerging solutions

      Trabjerg, Esben, Nazari, Z. E. & Rand, Kasper Dyrberg, Sep 2018, In: Trends in Analytical Chemistry. 106, p. 125-138

      Research output: Contribution to journal › Review › Research › peer-review

    18. Published

      Conformational analysis of large and highly disulfide-stabilized proteins by integrating online electrochemical reduction into an optimized H/D exchange mass spectrometry workflow

      Trabjerg, Esben, Jakobsen, R. U., Mysling, S., Christensen, S., Jørgensen, T. J. D. & Rand, Kasper Dyrberg, 6 Aug 2015, In: Analytical Chemistry. 87, 17, p. 8880–8888 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Conformational analysis of membrane proteins in phospholipid bilayer nanodiscs by hydrogen exchange mass spectrometry

      Hebling, C. M., Morgan, C. R., Stafford, D. W., Jorgenson, J. W., Rand, Kasper Dyrberg & Engen, J. R., 2010, In: Analytical Chemistry. 82, 13, p. 5415-9 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Conformational characterization of nerve growth factor-β reveals that its regulatory pro-part domain stabilizes three loop regions in its mature part

      Trabjerg, Esben, Kartberg, F., Christensen, S. & Rand, Kasper Dyrberg, 6 Oct 2017, In: Journal of Biological Chemistry. 292, 40, p. 16665-16676 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Conformational destabilization of Immunoglobulin G increases the low pH-binding affinity with the Neonatal Fc Receptor

      Walters, B. T., Jensen, P. F., Larraillet, V., Lin, K., Patapoff, T., Schlothauer, T., Rand, Kasper Dyrberg & Zhang, J., 22 Jan 2016, In: Journal of Biological Chemistry. 291, 4, p. 1817-1825 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Conformational dynamics of free and membrane-bound human Hsp70 in model cytosolic and endo-lysosomal environments

      Calvaresi, V., Truelsen, L. T., Larsen, S. B., Petersen, N. H. T., Kirkegaard, T. & Rand, Kasper Dyrberg, 2021, In: Communications Biology . 4, 1369.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Conformational dynamics of the Escherichia coli DNA polymerase manager proteins UmuD and UmuD'

      Fang, J., Rand, Kasper Dyrberg, Silva, M. C., Wales, T. E., Engen, J. R. & Beuning, P. J., 2010, In: Journal of Molecular Biology. 398, 1, p. 40-53 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Conformational dynamics of the human serotonin transporter during substrate and drug binding

      Möller, I. R., Slivacka, M., Nielsen, A. K., Rasmussen, Søren Gøgsig Faarup, Gether, Ulrik, Loland, Claus Juul & Rand, Kasper Dyrberg, 11 Apr 2019, In: Nature Communications. 10, 1, 1687.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Conformational heterogeneity of Savinase from NMR, HDX-MS and X-ray diffraction analysis

      Wu, S., Nguyen, T. T. T. N., Moroz, O. V., Turkenburg, J. P., Nielsen, J. E., Wilson, K. S., Rand, Kasper Dyrberg & Teilum, Kaare, 2020, In: PeerJ. 8, 17 p., e9408.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Conformational transitions in the membrane scaffold protein of phospholipid bilayer nanodiscs

      Morgan, C. R., Hebling, C. M., Rand, Kasper Dyrberg, Stafford, D. W., Jorgenson, J. W. & Engen, J. R., 2011, In: Molecular and Cellular Proteomics. 10, 9, p. M111.010876

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Conformationally Restricted Glycopeptide Backbone Inhibits Gas-Phase H/D Scrambling between Glycan and Peptide Moieties

      Code, C., Qiu, D., Solov'yov, I. A., Lee, J., Shin, H., Roland, C., Sagui, C., Houde, D., Rand, Kasper Dyrberg & Jørgensen, T. J. D., 2023, In: Journal of the American Chemical Society. 145, 44, p. 23925-23938

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Construct design, production, and characterization of Plasmodium falciparum 48/45 R0.6C subunit protein produced in Lactococcus lactis as candidate vaccine

      Singh, S. K., Roeffen, W., Mistarz, U. H., Chourasia, B. K., Yang, F., Rand, Kasper Dyrberg, Sauerwein, R. W. & Theisen, Michael, 2017, In: Microbial Cell Factories. 16, 1, 11 p., 97.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Crystal structure of a prolactin receptor antagonist bound to the extracellular domain of the prolactin receptor

      Svensson, L. A., Bondensgaard, K., Nørskov-Lauritsen, L., Christensen, L., Becker, P., Andersen, M., Maltesen, M. J., Rand, Kasper Dyrberg, Breinholt, J. & Maltesen, M. J., 2008, In: Journal of Biological Chemistry. 283, 27, p. 19085-94 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Deglycosylation by the Acidic Glycosidase PNGase H+ Enables Analysis of N-Linked Glycoproteins by Hydrogen/Deuterium Exchange Mass Spectrometry

      Comamala, G., Madsen, J. B., Voglmeir, J., Du, Y., Jensen, P. F., Østerlund, E. C., Trelle, M. B. & Rand, Kasper Dyrberg, 2020, In: Journal of the American Society for Mass Spectrometry. 31, 11, p. 2305-2312

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Development of a PNGase Rc Column for Online Deglycosylation of Complex Glycoproteins during HDX-MS

      Lambert, Thomas Ole Tandrup, Gramlich, M., Stutzke, L., Smith, L., Deng, D., Kaiser, P. D., Rothbauer, U., Benesch, J. L. P., Wagner, C., Koenig, M., Pompach, P., Novak, P., Zeck, A. & Rand, Kasper Dyrberg, 2023, In: Journal of the American Society for Mass Spectrometry. 34, 11, p. 2556–2566

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Development of a peptide probe for the occurrence of hydrogen (1H/2H) scrambling upon gas-phase fragmentation

      Rand, Kasper Dyrberg & Jørgensen, T., 2007, In: Analytical Chemistry. 79, 22, p. 8686-93 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Direct coupling of a flow-flow electromembrane extraction probe to LC-MS

      Fuchs, D., Gabel-Jensen, C., Jensen, H., Rand, Kasper Dyrberg, Pedersen-Bjergaard, Stig, Hansen, S. H. & Petersen, Nickolaj J., 2016, In: Analytica Chimica Acta. 905, p. 93-99 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Discovery of Highly Active Recombinant PNGase H+ Variants Through the Rational Exploration of Unstudied Acidobacterial Genomes

      Guo, R., Comamala, G., Yang, H., Gramlich, M., Du, Y., Wang, T., Zeck, A., Rand, Kasper Dyrberg, Liu, L. & Voglmeir, J., 2020, In: Frontiers in Bioengineering and Biotechnology. 8, 7 p., 741.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Dissecting the Binding Mode of Low Affinity Phage Display Peptide Ligands to Protein Targets by Hydrogen/Deuterium Exchange Coupled to Mass Spectrometry

      Leurs, U., Lohse, B., Ming, S. A., Cole, P. A., Clausen, Rasmus Prætorius, Kristensen, Jesper Langgaard & Rand, Kasper Dyrberg, 17 Oct 2014, In: Analytical Chemistry. 86, 23, p. 11734-11741 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      ETD in a traveling wave ion guide at tuned Z-spray ion source conditions allows for site-specific hydrogen/deuterium exchange measurements

      Rand, Kasper Dyrberg, Pringle, S. D., Morris, M., Engen, J. R. & Brown, J. M., 2011, In: Journal of The American Society for Mass Spectrometry. 22, 10, p. 1784-1793

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Electron capture dissociation proceeds with a low degree of intramolecular migration of peptide amide hydrogens

      Rand, Kasper Dyrberg, Adams, C. M., Zubarev, R. & Jørgensen, T., 2008, In: Journal of the American Chemical Society. 130, 4, p. 1341-9 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Electron transfer dissociation facilitates the measurement of deuterium incorporation into selectively labeled peptides with single residue resolution

      Zehl, M., Rand, Kasper Dyrberg, Jensen, O. & Jørgensen, T., 2008, In: Journal of the American Chemical Society. 130, 51, p. 17453-9 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Epitope Mapping of Human Polyclonal Antibodies to the fHbp Antigen of a Neisseria Meningitidis Vaccine by Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS)

      Grauslund, L. R., Ständer, S., Veggi, D., Andreano, E., Rand, Kasper Dyrberg & Norais, N., 2024, In: Molecular & cellular proteomics : MCP. 23, 3, 100734.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Epitope Mapping of Polyclonal Antibodies by Hydrogen–Deuterium Exchange Mass Spectrometry (HDX-MS)

      Ständer, S., Grauslund, L. R., Scarselli, M., Norais, N. & Rand, Kasper Dyrberg, 2021, In: Analytical Chemistry. 93, 34, p. 11669–11678

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Epitope and Paratope Mapping by HDX-MS Combined with SPR Elucidates the Difference in Bactericidal Activity of Two Anti-NadA Monoclonal Antibodies

      Grauslund, L. R., Calvaresi, V., Pansegrau, W., Norais, N. & Rand, Kasper Dyrberg, 2021, In: Journal of the American Society for Mass Spectrometry. 32, 7, p. 1575–1582

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Epitope mapping of a blood-brain barrier crossing antibody targeting the cysteine-rich region of IGF1R using hydrogen-exchange mass spectrometry enabled by electrochemical reduction

      Sheff, J., Kelly, J., Foss, M., Brunette, E., Kemmerich, K., van Faassen, H., Raphael, S., Hussack, G., Comamala, G., Rand, Kasper Dyrberg & Stanimirovic, D. B., 2023, In: Journal of Biochemistry. 173, 2, p. 95-105

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Expression, Purification and Characterization of GMZ2'.10C, a Complex Disulphide-Bonded Fusion Protein Vaccine Candidate against the Asexual and Sexual Life-Stages of the Malaria-Causing Plasmodium falciparum Parasite

      Mistarz, U. H., Singh, S. K., Nguyen, T. T. T. N., Roeffen, W., Yang, F., Lissau, C., Madsen, S. M., Vrang, A., Tiendrebeogo, R. W., Kana, Ikhlaq Hussain, Sauerwein, R. W., Theisen, Michael & Rand, Kasper Dyrberg, 1 Sep 2017, In: Pharmaceutical Research. 34, 9, p. 1970-1983 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. False EX1 signatures caused by sample carryover during HX MS analyses

      Fang, J., Rand, Kasper Dyrberg, Beuning, P. J. & Engen, J. R., 2011, In: International Journal of Mass Spectrometry. 302, 1-3, p. 19-25 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Formation of covalent di-tyrosine dimers in recombinant α-synuclein

      van Maarschalkerweerd, A., Pedersen, M., Peterson, H., Nilsson, M., Nguyen, T., Skamris, T., Rand, Kasper Dyrberg, Vetri, V., Langkilde, Annette Eva & Vestergaard, Bente, 19 Oct 2015, In: Intrinsically Disordered Proteins. 3, 1, p. 1-12 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Fully Automated Electro Membrane Extraction Autosampler for LC-MS Systems Allowing Soft Extractions for High-Throughput Applications.

      Fuchs, D., Pedersen-Bjergaard, Stig, Jensen, H., Rand, Kasper Dyrberg, Hansen, S. H. & Petersen, Nickolaj J., 29 May 2016, In: Analytical Chemistry. 88, 13, p. 6797−6804 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Gas-phase fragmentation of peptides by MALDI in-source decay with limited amide hydrogen (1H/2H) scrambling

      Bache, N., Rand, Kasper Dyrberg, Roepstorff, P. & Jørgensen, T., 2008, In: Analytical Chemistry. 80, 16, p. 6431-5 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Gas-phase fragmentation of peptides to increase the spatial resolution of the Hydrogen Exchange Mass Spectrometry experiment

      Jensen, P. F. & Rand, Kasper Dyrberg, Mar 2016, Hydrogen Exchange Mass Spectrometry of Proteins: Fundamentals, Methods and Applications. Weis, D. (ed.). Wiley, p. 127-148 22 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    49. Gas-phase hydrogen/deuterium exchange in a traveling wave ion guide for the examination of protein conformations

      Rand, Kasper Dyrberg, Pringle, S. D., Murphy, J. P., Fadgen, K. E., Brown, J. & Engen, J. R., 2009, In: Analytical Chemistry. 81, 24, p. 10019-28 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Getting to the core of protein pharmaceuticals – comprehensive structure analysis by mass spectrometry

      Leurs, U., Mistarz, U. H. & Rand, Kasper Dyrberg, 2015, In: European Journal of Pharmaceutics and Biopharmaceutics. 93, p. 95-109 15 p.

      Research output: Contribution to journal › Review › Research › peer-review

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