Birger Brodin Larsen

Birger Brodin Larsen

Professor


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  1. Published

    The expression of Claudin-5 correlates with transendothelial electrical resistance (TEER) in BCEC/rat astrocyte blood-brain barrier models

    Helms, H. C. C., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 2010.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  2. Published

    Characterization of in vitro blood-brain barrier models

    Helms, H. C. C., Eriksson, A. H., Nielsen, C. U., Waagepetersen, Helle S., Walls, Anne Byriel & Larsen, Birger Brodin, 9 Aug 2009. 1 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  3. Published

    Excitatory amino acid transporter-1 (EAAT1) is the main transporter responsible for abluminal uptake of L-glutamate in bovine brain endothelial cells

    Helms, H. C. C., Groth, S., Mikél, M., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 27 May 2013.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  4. Published

    A Tight Blood-Brain Barrier Model Displays Brain-to-Blood Efflux of Substrates for the ABC-Transporters, P-gp, BCRP and MRP-1

    Helms, H. C. C., Hersom, M. N. S., Kuhlmann, L. B., Badolo, L., Nielsen, C. U. & Larsen, Birger Brodin, 11 Sep 2014. 1 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  5. Published

    Glutamate efflux from brain to blood - Studies in an in vitro blood-brain barrier model

    Helms, H. C. C., Madelung, R., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 2012.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  6. Published

    Efflux transporter expression in a tight in vitro model of the blood brain barrier

    Helms, H. C. C., Hersom, M. N. S., Kuhlmann, L. B., Badolo, L., Nielsen, C. U. & Larsen, Birger Brodin, 10 Dec 2014. 1 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  7. Published

    In vitro models of the blood-brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use

    Helms, H. C. C., Abbott, N. J., Burek, M., Cecchelli, R., Couraud, P., Deli, M. A., Förster, C., Galla, H. J., Romero, I. A., Shusta, E. V., Stebbins, M. J., Vandenhaute, E., Weksler, B. & Larsen, Birger Brodin, May 2016, In: Journal of Cerebral Blood Flow and Metabolism. 36, 5, p. 862-90 29 p.

    Research output: Contribution to journal › Review › Research › peer-review

  8. Published

    Hjernens forsvarsmur kortlagt og kopieret

    Helms, H. C., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 2010, In: Lægemiddelforskning. 2010, p. 22-24

    Research output: Contribution to journal › Journal article › Communication

  9. Published

    An Electrically Tight In Vitro Blood-Brain Barrier Model Displays Net Brain-to-Blood Efflux of Substrates for the ABC Transporters, P-gp, Bcrp and Mrp-1

    Helms, H. C., Hersom, M., Kuhlmann, L. B., Badolo, L., Nielsen, C. U. & Larsen, Birger Brodin, 17 Jun 2014, In: A A P S Journal. 16, 5, p. 1046-1055 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Paracellular tightness and claudin-5 expression is increased in the BCEC/Astrocyte blood-brain barrier model by increasing media buffer capacity during growth

    Helms, H. C., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, Dec 2010, In: The AAPS Journal. 12, 4, p. 759-770

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Characterisation of in-vitro blood-brain barrier models

    Helms, H. C., Eriksson, A. H., Waagepetersen, Helle S. & Larsen, Birger Brodin, 2009.

    Research output: Contribution to conference › Poster › Research

  12. Published

    In vitro evidence for the brain glutamate efflux hypothesis: brain endothelial cells cocultured with astrocytes display a polarized brain-to-blood transport of glutamate

    Helms, H. C., Madelung, R., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 2012, In: Glia. 60, 6, p. 882-893

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Characterization of the L-glutamate clearance pathways across the blood-brain barrier and the effect of astrocytes in an in vitro blood-brain barrier model

    Helms, H. C., Aldana, Blanca, Groth, S., Jensen, M. M., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 2017, In: Journal of Cerebral Blood Flow and Metabolism. 37, 12, p. 3744–3758

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Generation of primary cultures of bovine brain endothelial cells and setup of cocultures with rat astrocytes

    Helms, H. C. & Larsen, Birger Brodin, 2014, In: Methods in molecular biology (Clifton, N.J.). 1135, p. 365-82 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories

    Hayeshi, R., Hilgendorf, C., Arthursson, P., Augustijns, P., Larsen, Birger Brodin, Dehertogh, P., Fisher, K., Fossati, L., Hovenkamp, E., Korjamo, T., Masungi, C., Maubon, N., Mols, R., Mullertz, Anette , Mönkkönen, J., O´Driscoll, C., Oppers-Tiemissen, H. M., Ragnarsson, E. G. E., Rooseboom, M. & Ungell, A., 2008, In: European Journal of Pharmaceutical Sciences. 35, 5, p. 383-396

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Generation of a rat in-vitro blood-brain barrier model and initial insights on excitatory amino acid transporter expression

    Groth, S., Moos, T., Helms, H. C. C. & Larsen, Birger Brodin, 2012. 1 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  17. Published

    Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017

    Greenwood, J., Hammarlund-Udenaes, M., Jones, H. C., Stitt, A. W., Vandenbrouke, R. E., Romero, I. A., Campbell, M., Fricker, G., Larsen, Birger Brodin, Manninga, H., Gaillard, P. J., Schwaninger, M., Webster, C., Wicher, K. B. & Khrestchatisky, M., 7 Nov 2017, In: Fluids and Barriers of the CNS. 14, 11 p., 31.

    Research output: Contribution to journal › Review › Research › peer-review

  18. Published

    Molekylær biofarmaci - når medicinen skyder genvej!

    Gram, L. K., Omkvist, D. H., Larsen, M., Nielsen, C. U., Larsen, Birger Brodin & Steffansen, I. D., 2007, In: Lægemiddelforskning. p. 16-17

    Research output: Contribution to journal › Journal article › Communication

  19. Published

    Down-regulation of selected Blood-brain Barrier Specific Genes from Capillaries to Bovine In Vitro Models

    Goldeman, C., Saaby, L. & Larsen, Birger Brodin, 14 Sep 2016. 1 p.

    Research output: Contribution to conference › Poster › Research › peer-review

  20. Published

    Initial Attempts of Development and Characterization of an In Vitro Blood Brain Barrier Model Derived from Human Pluripotent Stem Cells

    Goldeman, C., Saaby, L., Hall, Vanessa Jane, Hyttel, P. & Larsen, Birger Brodin, 8 Dec 2016. 1 p.

    Research output: Contribution to conference › Poster › Research › peer-review

  21. Published

    Development and Characterization of a Brain Endothelial Cell Phenotype using Human Induced Pluripotent Stem Cells

    Goldeman, C., Saaby, L., Holst, B., Hall, Vanessa Jane, Hyttel, P. & Larsen, Birger Brodin, 2 Nov 2017.

    Research output: Contribution to conference › Poster › Research › peer-review

  22. Published

    Culture-induced changes in mRNA expression levels of efflux and SLC-transporters in brain endothelial cells

    Goldeman, C., Ozgür, Burak & Larsen, Birger Brodin, 22 Apr 2020, In: Fluids and Barriers of the CNS. 17, 32, 12 p., 32.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Human induced pluripotent stem cells (BIONi010-C) generate tight cell monolayers with blood-brain barrier traits and functional expression of large neutral amino acid transporter 1 (SLC7A5)

    Goldeman, C., Andersen, M., Al-Robai, A., Buchholtz, T., Svane, Nana Isabella, Ozgür, Burak, Holst, B., Shusta, E., Hall, Vanessa Jane, Saaby, Lasse, Hyttel, P. & Larsen, Birger Brodin, 2021, In: European Journal of Pharmaceutical Sciences. 156, 14 p., 105577.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Highly cationic cell-penetrating peptides affect the barrier integrity and facilitates mannitol permeation in a human stem cell-based blood-brain barrier model

    Frøslev, Patrick, Franzyk, Henrik, Ozgür, Burak, Larsen, Birger Brodin & Kristensen, Mie, 2022, In: European Journal of Pharmaceutical Sciences. 168, 10 p., 106054.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Gly-sar is a substrate for the human proton coupled amino acid trasporter 1, hPAT1 (SLC36A1)

    Frølund, S. B., Holm, R., Larsen, Birger Brodin & Nielsen, C. U., 2010.

    Research output: Contribution to conference › Poster › Research

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