Kasper Dyrberg Rand
Professor
- 2006
- Published
Allosteric activation of coagulation factor VIIa visualized by hydrogen exchange
Rand, Kasper Dyrberg, Jørgensen, T., Olsen, Ole, Persson, E., Jensen, O., Stennicke, H. R. & Andersen, M., 2006, In: Journal of Biological Chemistry. 281, 32, p. 23018-24 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular analysis of the interaction between the hematopoietic master transcription factors GATA-1 and PU.1.
Liew, C. W., Rand, Kasper Dyrberg, Simpson, R. J. Y., Yung, W. W., Mansfield, R. E., Crossley, M., Proetorius-Ibba, M., Nerlov, C., Poulsen, F. M. & Mackay, J. P., 2006, In: Journal of Biological Chemistry. 281, 38, p. 28296-306 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
A combined structural dynamics approach identifies a putative switch in factor VIIa employed by tissue factor to initiate blood coagulation
Olsen, O. H., Rand, Kasper Dyrberg, Østergaard, H. & Persson, E., 2007, In: Protein Science. 16, 4, p. 671-82 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Development of a peptide probe for the occurrence of hydrogen (1H/2H) scrambling upon gas-phase fragmentation
Rand, Kasper Dyrberg & Jørgensen, T., 2007, In: Analytical Chemistry. 79, 22, p. 8686-93 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
Crystal structure of a prolactin receptor antagonist bound to the extracellular domain of the prolactin receptor
Svensson, L. A., Bondensgaard, K., Nørskov-Lauritsen, L., Christensen, L., Becker, P., Andersen, M., Maltesen, M. J., Rand, Kasper Dyrberg, Breinholt, J. & Maltesen, M. J., 2008, In: Journal of Biological Chemistry. 283, 27, p. 19085-94 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Electron capture dissociation proceeds with a low degree of intramolecular migration of peptide amide hydrogens
Rand, Kasper Dyrberg, Adams, C. M., Zubarev, R. & Jørgensen, T., 2008, In: Journal of the American Chemical Society. 130, 4, p. 1341-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Electron transfer dissociation facilitates the measurement of deuterium incorporation into selectively labeled peptides with single residue resolution
Zehl, M., Rand, Kasper Dyrberg, Jensen, O. & Jørgensen, T., 2008, In: Journal of the American Chemical Society. 130, 51, p. 17453-9 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Gas-phase fragmentation of peptides by MALDI in-source decay with limited amide hydrogen (1H/2H) scrambling
Bache, N., Rand, Kasper Dyrberg, Roepstorff, P. & Jørgensen, T., 2008, In: Analytical Chemistry. 80, 16, p. 6431-5 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hydrogen atom scrambling in selectively labeled anionic peptides upon collisional activation by MALDI tandem time-of-flight mass spectrometry
Bache, N., Rand, Kasper Dyrberg, Roepstorff, P., Ploug, Michael & Jørgensen, T., 2008, In: Journal of The American Society for Mass Spectrometry. 19, 12, p. 1719-25 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
The origins of enhanced activity in factor VIIa analogs and the interplay between key allosteric sites revealed by hydrogen exchange mass spectrometry
Rand, Kasper Dyrberg, Andersen, M., Olsen, O. H., Jørgensen, T., Ostergaard, H., Jensen, O., Stennicke, H. R. & Persson, E., 2008, In: Journal of Biological Chemistry. 283, 19, p. 13378-87 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
Gas-phase hydrogen/deuterium exchange in a traveling wave ion guide for the examination of protein conformations
Rand, Kasper Dyrberg, Pringle, S. D., Murphy, J. P., Fadgen, K. E., Brown, J. & Engen, J. R., 2009, In: Analytical Chemistry. 81, 24, p. 10019-28 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Protein hydrogen exchange measured at single-residue resolution by electron transfer dissociation mass spectrometry
Rand, Kasper Dyrberg, Zehl, M., Jensen, O. & Jørgensen, T., 2009, In: Analytical Chemistry. 81, 14, p. 5577-84 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
Conformational analysis of membrane proteins in phospholipid bilayer nanodiscs by hydrogen exchange mass spectrometry
Hebling, C. M., Morgan, C. R., Stafford, D. W., Jorgenson, J. W., Rand, Kasper Dyrberg & Engen, J. R., 2010, In: Analytical Chemistry. 82, 13, p. 5415-9 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
Conformational dynamics of the Escherichia coli DNA polymerase manager proteins UmuD and UmuD'
Fang, J., Rand, Kasper Dyrberg, Silva, M. C., Wales, T. E., Engen, J. R. & Beuning, P. J., 2010, In: Journal of Molecular Biology. 398, 1, p. 40-53 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
Loss of ammonia during electron-transfer dissociation of deuterated peptides as an inherent gauge of gas-phase hydrogen scrambling
Rand, Kasper Dyrberg, Zehl, M., Jensen, O. & Jørgensen, T., 2010, In: Analytical Chemistry. 82, 23, p. 9755-62 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
Antibody mechanics on a membrane-bound HIV segment essential for GP41-targeted viral neutralization
Kim, M., Sun, Z. J., Rand, Kasper Dyrberg, Shi, X., Song, L., Cheng, Y., Fahmy, A. F., Majumdar, S., Ofek, G., Yang, Y., Kwong, P. D., Wang, J., Engen, J. R., Wagner, G. & Reinherz, E. L., 2011, In: Nature Structural and Molecular Biology. 18, 11, p. 1235-43 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Conformational transitions in the membrane scaffold protein of phospholipid bilayer nanodiscs
Morgan, C. R., Hebling, C. M., Rand, Kasper Dyrberg, Stafford, D. W., Jorgenson, J. W. & Engen, J. R., 2011, In: Molecular and Cellular Proteomics. 10, 9, p. M111.010876Research output: Contribution to journal › Journal article › Research › peer-review
- Published
ETD in a traveling wave ion guide at tuned Z-spray ion source conditions allows for site-specific hydrogen/deuterium exchange measurements
Rand, Kasper Dyrberg, Pringle, S. D., Morris, M., Engen, J. R. & Brown, J. M., 2011, In: Journal of The American Society for Mass Spectrometry. 22, 10, p. 1784-1793Research output: Contribution to journal › Journal article › Research › peer-review
False EX1 signatures caused by sample carryover during HX MS analyses
Fang, J., Rand, Kasper Dyrberg, Beuning, P. J. & Engen, J. R., 2011, In: International Journal of Mass Spectrometry. 302, 1-3, p. 19-25 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Spatially resolved protein hydrogen exchange measured by matrix-assisted laser desorption ionization in-source decay
Rand, Kasper Dyrberg, Bache, N., Nedertoft, M. M. & Jørgensen, T., 2011, In: Analytical Chemistry. 83, 23, p. 8859-62 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Investigation of amide hydrogen back-exchange in Asp and His repeats measured by hydrogen (1H/2H) exchange mass spectrometry
Rand, Kasper Dyrberg, Lund, F. W., Amon, S. & Jørgensen, Thomas, Apr 2011, In: International Journal of Mass Spectrometry.Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
Massespektrometri viser vejen til forbedrede proteinlægemidler
Song, H. & Rand, Kasper Dyrberg, 2012, In: Lægemiddelforskning. 2012, p. 43-46Research output: Contribution to journal › Journal article › Communication
- Published
Site-specific analysis of gas-phase hydrogen/deuterium exchange of peptides and proteins by electron transfer dessociation
Rand, Kasper Dyrberg, Pringle, S. D., Morris, M. & Brown, J. M., 2012, In: Analytical Chemistry. 84, 4, p. 1931-1940Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
Pinpointing changes in higher-order protein structure by hydrogen/deuterium exchange coupled to electron transfer dissociation mass spectrometry
Rand, Kasper Dyrberg, 15 Mar 2013, In: International Journal of Mass Spectrometry. 338, p. 2-10 9 p.Research output: Contribution to journal › Review › Research › peer-review
- 2014
- Published
A conformational investigation of propeptide binding to the integral membrane protein γ-glutamyl carboxylase using nanodisc hydrogen exchange mass spectrometry
Parker, C. H., Morgan, C. R., Rand, Kasper Dyrberg, Engen, J. R., Jorgenson, J. W. & Stafford, D. W., 11 Mar 2014, In: Biochemistry. 53, 9, p. 1511-20 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Substrate- and Cofactor-independent Inhibition of Histone Demethylase KDM4C
Leurs, U., Lohse, B., Rand, Kasper Dyrberg, Ming, S., Riise, E. S., Cole, P. A., Kristensen, Jesper Langgaard & Clausen, Rasmus Prætorius, 11 Jul 2014, In: A C S Chemical Biology. 9, 9, p. 2131-2138 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dissecting the Binding Mode of Low Affinity Phage Display Peptide Ligands to Protein Targets by Hydrogen/Deuterium Exchange Coupled to Mass Spectrometry
Leurs, U., Lohse, B., Ming, S. A., Cole, P. A., Clausen, Rasmus Prætorius, Kristensen, Jesper Langgaard & Rand, Kasper Dyrberg, 17 Oct 2014, In: Analytical Chemistry. 86, 23, p. 11734-11741 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Measuring the hydrogen/deuterium exchange of proteins at high spatial resolution by mass spectrometry: overcoming gas-phase hydrogen/deuterium scrambling
Rand, Kasper Dyrberg, Zehl, M. & Jørgensen, T. J. D., 21 Oct 2014, In: Accounts of Chemical Research. 47, 10, p. 3018-27 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sites involved in intra- and interdomain allostery associated with the activation of factor VIIa pinpointed by hydrogen-deuterium exchange and electron transfer dissociation mass spectrometry
Song, H., Olsen, O. H., Persson, E. & Rand, Kasper Dyrberg, 24 Oct 2014, In: The Journal of Biological Chemistry. 289, p. 35388-96 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Simple setup for gas-phase H/D exchange mass spectrometry coupled to electron transfer dissociation and ion mobility for analysis of polypeptide structure on a liquid chromatographic time scale
Mistarz, U. H., Brown, J. M., Haselmann, K. F. & Rand, Kasper Dyrberg, 2 Dec 2014, In: Analytical Chemistry. 86, 23, p. 11868-76 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
Getting to the core of protein pharmaceuticals – comprehensive structure analysis by mass spectrometry
Leurs, U., Mistarz, U. H. & Rand, Kasper Dyrberg, 2015, In: European Journal of Pharmaceutics and Biopharmaceutics. 93, p. 95-109 15 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Measuring the binding interfaces of protein complexes by gas-phase hydrogen/deuterium exchange mass spectrometry (gas-phase HDX-MS)
Mistarz, U. H., Brown, J. M., Haselmann, K. F. & Rand, Kasper Dyrberg, 2015.Research output: Contribution to conference › Conference abstract for conference › Research
- Published
Rapid and simple preparation of thiol-ene emulsion-templated monoliths and their application as enzymatic microreactors
Lafleur, J. P., Senkbeil, S., Novotny, J., Nys, G., Bøgelund, N., Rand, Kasper Dyrberg, Foret, F. & Kutter, Jörg P., 2015, In: Lab On a Chip. 15, 10, p. 2162-72 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Investigating the Interaction between the Neonatal Fc Receptor and Monoclonal Antibody Variants by Hydrogen/Deuterium Exchange Mass Spectrometry
Jensen, P. F., Larraillet, V., Schlothauer, T., Kettenberger, H., Hilger, M. & Rand, Kasper Dyrberg, Jan 2015, In: Molecular and Cellular Proteomics. 14, 1, p. 148-61 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Probing the Conformational and Functional Consequences of Disulfide Bond Engineering in Growth Hormone by Hydrogen-Deuterium Exchange Mass Spectrometry Coupled to Electron Transfer Dissociation
Seger, S. T., Breinholt, J., Faber, J. H., Andersen, M. D., Wiberg, C., Schjødt, C. B. & Rand, Kasper Dyrberg, 16 Jun 2015, In: Analytical Chemistry. 87, 12, p. 5973-80 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conformational analysis of large and highly disulfide-stabilized proteins by integrating online electrochemical reduction into an optimized H/D exchange mass spectrometry workflow
Trabjerg, Esben, Jakobsen, R. U., Mysling, S., Christensen, S., Jørgensen, T. J. D. & Rand, Kasper Dyrberg, 6 Aug 2015, In: Analytical Chemistry. 87, 17, p. 8880–8888 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Formation of covalent di-tyrosine dimers in recombinant α-synuclein
van Maarschalkerweerd, A., Pedersen, M., Peterson, H., Nilsson, M., Nguyen, T., Skamris, T., Rand, Kasper Dyrberg, Vetri, V., Langkilde, Annette Eva & Vestergaard, Bente, 19 Oct 2015, In: Intrinsically Disordered Proteins. 3, 1, p. 1-12 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
A simple sheathless CE-MS interface with a sub-micrometer electrical contact fracture for sensitive analysis of peptide and protein samples
Nguyen, T. T. T. N., Petersen, Nickolaj J. & Rand, Kasper Dyrberg, 2016, In: Analytica Chimica Acta. 936, p. 157–167 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Analytical Techniques in the Pharmaceutical Sciences
Leurs, U., Mistarz, U. H. & Rand, Kasper Dyrberg, 2016, Analytical Techniques in the Pharmaceutical Sciences. Müllertz, A., Perrie, Y. & Rades, T. (eds.). Springer Publishing Company, p. 253-289 36 p. (Advances in Delivery Science and Technology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Direct coupling of a flow-flow electromembrane extraction probe to LC-MS
Fuchs, D., Gabel-Jensen, C., Jensen, H., Rand, Kasper Dyrberg, Pedersen-Bjergaard, Stig, Hansen, S. H. & Petersen, Nickolaj J., 2016, In: Analytica Chimica Acta. 905, p. 93-99 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Impact of the ‘Austrian’ Mutation of the Amyloid Precursor Protein Transmembrane Helix is Communicated to the Hinge Region
Stelzer, W., Scharnagl, C., Leurs, U., Rand, Kasper Dyrberg & Langosch, D., 2016, In: ChemistrySelect. 1, 15, p. 4408-4412 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conformational destabilization of Immunoglobulin G increases the low pH-binding affinity with the Neonatal Fc Receptor
Walters, B. T., Jensen, P. F., Larraillet, V., Lin, K., Patapoff, T., Schlothauer, T., Rand, Kasper Dyrberg & Zhang, J., 22 Jan 2016, In: Journal of Biological Chemistry. 291, 4, p. 1817-1825 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Probing the Binding Interfaces of Protein Complexes Using Gas-Phase H/D Exchange Mass Spectrometry
Mistarz, U. H., Brown, J. M., Haselmann, K. F. & Rand, Kasper Dyrberg, 2 Feb 2016, In: Structure. 24, 2, p. 310-318 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conformational Analysis of Proteins in Highly Concentrated Solutions by Dialysis-Coupled Hydrogen/Deuterium Exchange Mass Spectrometry
Houde, D., Esmail Nazari, Z., Bou-Assaf, G. M., Weiskopf, A. S. & Rand, Kasper Dyrberg, 9 Feb 2016, In: Journal of the American Society for Mass Spectrometry. 27, 4, p. 669–676 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Gas-phase fragmentation of peptides to increase the spatial resolution of the Hydrogen Exchange Mass Spectrometry experiment
Jensen, P. F. & Rand, Kasper Dyrberg, Mar 2016, Hydrogen Exchange Mass Spectrometry of Proteins: Fundamentals, Methods and Applications. Weis, D. (ed.). Wiley, p. 127-148 22 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Hydrogen exchange: A sensitive analytical window into protein conformation and dynamics
Jensen, P. F. & Rand, Kasper Dyrberg, Mar 2016, Hydrogen Exchange Mass Spectrometry of protein: Fundamentals, Methods and Applications. Weis, D. (ed.). Wiley, p. 1-17 17 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Fully Automated Electro Membrane Extraction Autosampler for LC-MS Systems Allowing Soft Extractions for High-Throughput Applications.
Fuchs, D., Pedersen-Bjergaard, Stig, Jensen, H., Rand, Kasper Dyrberg, Hansen, S. H. & Petersen, Nickolaj J., 29 May 2016, In: Analytical Chemistry. 88, 13, p. 6797−6804 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Investigating the Role of Artemin Glycosylation
Danwen, Q., Code, C., Quan, C., Gong, B., Arndt, J., Pepinsky, B., Rand, Kasper Dyrberg & Houde, D., Jun 2016, In: Pharmaceutical Research. 33, 6, p. 1383-1398 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A novel sensitive sheathless CE-MS device for peptide and protein analysis
Nguyen, T. T. T. N., Petersen, Nickolaj J. & Rand, Kasper Dyrberg, 8 Jun 2016. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research
- Published
Rapid Conformational Analysis of Protein Drugs in Formulation by Hydrogen/Deuterium Exchange Mass Spectrometry (HDX-MS)
Esmail Nazari, Z., van de Weert, Marco, Bou-Assaf, G., Houde, D., Weiskopf, A. & Rand, Kasper Dyrberg, 1 Jul 2016, In: Journal of Pharmaceutical Sciences. 105, 11, p. 3269–3277 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 34783804
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Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments
Research output: Contribution to journal › Journal article › Research › peer-review
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The First Community-Wide, Comparative Cross-linking Mass Spectrometry Study
Research output: Contribution to journal › Journal article › Research › peer-review
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Construct design, production, and characterization of Plasmodium falciparum 48/45 R0.6C subunit protein produced in Lactococcus lactis as candidate vaccine
Research output: Contribution to journal › Journal article › Research › peer-review
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