Does systemic hydrochlorothiazide increase the risk of developing ultraviolet radiation-induced skin tumours in hairless mice?

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Does systemic hydrochlorothiazide increase the risk of developing ultraviolet radiation-induced skin tumours in hairless mice? / Lerche, Catharina M.; Al-Chaer, Rami Nabil; Wulf, Hans Christian.

In: Experimental Dermatology, Vol. 32, No. 4, 2023, p. 341-347.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Lerche, CM, Al-Chaer, RN & Wulf, HC 2023, 'Does systemic hydrochlorothiazide increase the risk of developing ultraviolet radiation-induced skin tumours in hairless mice?', Experimental Dermatology, vol. 32, no. 4, pp. 341-347. https://doi.org/10.1111/exd.14703

APA

Lerche, C. M., Al-Chaer, R. N., & Wulf, H. C. (2023). Does systemic hydrochlorothiazide increase the risk of developing ultraviolet radiation-induced skin tumours in hairless mice? Experimental Dermatology, 32(4), 341-347. https://doi.org/10.1111/exd.14703

Vancouver

Lerche CM, Al-Chaer RN, Wulf HC. Does systemic hydrochlorothiazide increase the risk of developing ultraviolet radiation-induced skin tumours in hairless mice? Experimental Dermatology. 2023;32(4):341-347. https://doi.org/10.1111/exd.14703

Author

Lerche, Catharina M. ; Al-Chaer, Rami Nabil ; Wulf, Hans Christian. / Does systemic hydrochlorothiazide increase the risk of developing ultraviolet radiation-induced skin tumours in hairless mice?. In: Experimental Dermatology. 2023 ; Vol. 32, No. 4. pp. 341-347.

Bibtex

@article{7c7843cd15914e5abc4316acd25b3a40,
title = "Does systemic hydrochlorothiazide increase the risk of developing ultraviolet radiation-induced skin tumours in hairless mice?",
abstract = "Hydrochlorothiazide (HCTZ) is a frequently prescribed diuretic that exhibits photosensitizing properties. It is used to treat hypertension and edema. Dermato-epidemiological studies in various populations have linked HCTZ treatment with increased risk of particular types of skin cancer, including malignant melanoma (lentigo subtype), and both basal cell carcinoma and squamous cell carcinoma (SCC). This study investigated whether either of two different doses of HCTZ increased the risk of SCC development in mice exposed to ultraviolet radiation (UVR). A total of three groups of hairless mice were used in this study (total, N = 71). One group received a low dose (0.26 mg/mouse/day) and another group received a high dose (0.52 mg/mouse/day) of HCTZ in their drinking water; a third UVR control group received only tap water. All three groups were irradiated with UVR until the mice developed three tumours that were 4 mm in size. The times to SCC tumour development were recorded. In the low-dose group, the median time to develop an SCC tumour was 170 days; in both the high-dose group and the control group, the median time to develop anexd SCC tumour was 163 days (p ≥ 0.331). In our hairless mouse model, we found that mice treated with UVR plus HCTZ did not develop SCCs more rapidly than mice treated with UVR but not HCTZ.",
keywords = "hairless mice, hydrochlorothiazide, photocarcinogenesis, skin tumours, squamous cell carcinoma",
author = "Lerche, {Catharina M.} and Al-Chaer, {Rami Nabil} and Wulf, {Hans Christian}",
note = "Funding Information: The work was funded by the Copenhagen University Hospital, Bispebjerg and Frederiksberg. Funding Information: C.M.L is funded by an unrestricted grant from the Lundbeck Foundation (R307‐2018‐3318). ",
year = "2023",
doi = "10.1111/exd.14703",
language = "English",
volume = "32",
pages = "341--347",
journal = "Experimental Dermatology",
issn = "1600-0625",
publisher = "Wiley",
number = "4",

}

RIS

TY - JOUR

T1 - Does systemic hydrochlorothiazide increase the risk of developing ultraviolet radiation-induced skin tumours in hairless mice?

AU - Lerche, Catharina M.

AU - Al-Chaer, Rami Nabil

AU - Wulf, Hans Christian

N1 - Funding Information: The work was funded by the Copenhagen University Hospital, Bispebjerg and Frederiksberg. Funding Information: C.M.L is funded by an unrestricted grant from the Lundbeck Foundation (R307‐2018‐3318).

PY - 2023

Y1 - 2023

N2 - Hydrochlorothiazide (HCTZ) is a frequently prescribed diuretic that exhibits photosensitizing properties. It is used to treat hypertension and edema. Dermato-epidemiological studies in various populations have linked HCTZ treatment with increased risk of particular types of skin cancer, including malignant melanoma (lentigo subtype), and both basal cell carcinoma and squamous cell carcinoma (SCC). This study investigated whether either of two different doses of HCTZ increased the risk of SCC development in mice exposed to ultraviolet radiation (UVR). A total of three groups of hairless mice were used in this study (total, N = 71). One group received a low dose (0.26 mg/mouse/day) and another group received a high dose (0.52 mg/mouse/day) of HCTZ in their drinking water; a third UVR control group received only tap water. All three groups were irradiated with UVR until the mice developed three tumours that were 4 mm in size. The times to SCC tumour development were recorded. In the low-dose group, the median time to develop an SCC tumour was 170 days; in both the high-dose group and the control group, the median time to develop anexd SCC tumour was 163 days (p ≥ 0.331). In our hairless mouse model, we found that mice treated with UVR plus HCTZ did not develop SCCs more rapidly than mice treated with UVR but not HCTZ.

AB - Hydrochlorothiazide (HCTZ) is a frequently prescribed diuretic that exhibits photosensitizing properties. It is used to treat hypertension and edema. Dermato-epidemiological studies in various populations have linked HCTZ treatment with increased risk of particular types of skin cancer, including malignant melanoma (lentigo subtype), and both basal cell carcinoma and squamous cell carcinoma (SCC). This study investigated whether either of two different doses of HCTZ increased the risk of SCC development in mice exposed to ultraviolet radiation (UVR). A total of three groups of hairless mice were used in this study (total, N = 71). One group received a low dose (0.26 mg/mouse/day) and another group received a high dose (0.52 mg/mouse/day) of HCTZ in their drinking water; a third UVR control group received only tap water. All three groups were irradiated with UVR until the mice developed three tumours that were 4 mm in size. The times to SCC tumour development were recorded. In the low-dose group, the median time to develop an SCC tumour was 170 days; in both the high-dose group and the control group, the median time to develop anexd SCC tumour was 163 days (p ≥ 0.331). In our hairless mouse model, we found that mice treated with UVR plus HCTZ did not develop SCCs more rapidly than mice treated with UVR but not HCTZ.

KW - hairless mice

KW - hydrochlorothiazide

KW - photocarcinogenesis

KW - skin tumours

KW - squamous cell carcinoma

U2 - 10.1111/exd.14703

DO - 10.1111/exd.14703

M3 - Journal article

C2 - 36333872

AN - SCOPUS:85142255270

VL - 32

SP - 341

EP - 347

JO - Experimental Dermatology

JF - Experimental Dermatology

SN - 1600-0625

IS - 4

ER -

ID: 328693448