A Bayesian Generative Model with Gaussian Process Priors for Thermomechanical Analysis of Micro-Resonators

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

  • Maximillian F. Vording
  • Peter O. Okeyo
  • Juan J.R. Guillamon
  • Peter E. Larsen
  • Mikkel N. Schmidt
  • Tommy S. Alstrom

Thermal analysis using resonating micro-electromechanical systems shows great promise in characterizing materials in the early stages of research. Through thermal cycles and actuation using a piezoelectric speaker, the resonant behaviour of a model drug, theophylline monohydrate, is measured across the surface whilst using a laser-Doppler vibrometer for readout. Acquired is a sequence of spectra that are strongly correlated in time, temperature and spatial location of the readout. Traditionally, each spectrum is analyzed individually to locate the resonance peak. We propose a Bayesian model using a warped Gaussian process prior taking the correlations into account and demonstrate on both synthetic and experimental data, that it yields better estimates of both location and amplitude of the resonance peak. Thus, the proposed model can give a more precise characterization of drugs, which is important in drug discovery and development.

Original languageEnglish
Title of host publication2019 IEEE 29th International Workshop on Machine Learning for Signal Processing, MLSP 2019
PublisherIEEE
Publication date2019
Article number8918876
ISBN (Electronic)9781728108247
DOIs
Publication statusPublished - 2019
Event29th IEEE International Workshop on Machine Learning for Signal Processing, MLSP 2019 - Pittsburgh, United States
Duration: 13 Oct 201916 Oct 2019

Conference

Conference29th IEEE International Workshop on Machine Learning for Signal Processing, MLSP 2019
LandUnited States
ByPittsburgh
Periode13/10/201916/10/2019
SeriesIEEE International Workshop on Machine Learning for Signal Processing, MLSP
Volume2019-October
ISSN2161-0363

    Research areas

  • Bayesian learning and modeling, drug characterisation, Gaussian processes, thermomechanical analysis

ID: 241596297