CNS Drug Delivery and Barrier Modelling

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  1. 2021
  2. Published

    Brain endothelial cells metabolize glutamate via glutamate dehydrogenase to replenish TCA-intermediates and produce ATP under hypoglycemic conditions

    Hinca, S. B., Salcedo, C., Wagner, A., Goldeman, C., Sadat, E., Aibar, M. M. D., Maechler, P., Larsen, Birger Brodin, Aldana, Blanca & Helms, H. C. C., 2021, In: Journal of Neurochemistry. 157, 6, p. 1861-1875

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Human induced pluripotent stem cells (BIONi010-C) generate tight cell monolayers with blood-brain barrier traits and functional expression of large neutral amino acid transporter 1 (SLC7A5)

    Goldeman, C., Andersen, M., Al-Robai, A., Buchholtz, T., Svane, Nana Isabella, Ozgür, Burak, Holst, B., Shusta, E., Hall, Vanessa Jane, Saaby, Lasse, Hyttel, P. & Larsen, Birger Brodin, 2021, In: European Journal of Pharmaceutical Sciences. 156, 14 p., 105577.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Precapillary sphincters and pericytes at first-order capillaries as key regulators for brain capillary perfusion

    Zambach, S. A., Cai, Changsi, Helms, H. C. C., Hald, B. O., Dong, Y., Fordsmann, J. C., Nielsen, R. M., Hu, J., wbh615, wbh615, Larsen, Birger Brodin & Lauritzen, Martin, 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 26, e2023749118.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Revealing the importance of carrier-cargo association in delivery of insulin and lipidated insulin

    Diedrichsen, Ragna Guldsmed, Rønholt, Stine, Werner, U., Besenius, M., Leberer, E., Kristensen, Mie & Nielsen, Hanne Mørck, 2021, In: Journal of Controlled Release. 338, p. 8-21

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Screening novel CNS drug candidates for P-glycoprotein interactions using the cell line iP-gp: In vitro efflux ratios from iP-gp and MDCK-MDR1 monolayers compared to brain distribution data from mice

    Ozgür, Burak, Saaby, Lasse, Janfelt, Christian, Langthaler, K., Eneberg, E., Jacobsen, A., Badolo, L., Montanari, D. & Larsen, Birger Brodin, 2021, In: European Journal of Pharmaceutics and Biopharmaceutics. 169, p. 211-219

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Tight junctions in the blood–brain barrier promote edema formation and infarct size in stroke – Ambivalent effects of sealing proteins

    Winkler, L., Blasig, R., Breitkreuz-Korff, O., Berndt, P., Dithmer, S., Helms, H. C., Puchkov, D., Devraj, K., Kaya, M., Qin, Z., Liebner, S., Wolburg, H., Andjelkovic, A. V., Rex, A., Blasig, I. E. & Haseloff, R. F., 2021, In: Journal of Cerebral Blood Flow and Metabolism. 41, 1, p. 132-145

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Transendothelial electrical resistance measurement across the blood–brain barrier: A critical review of methods

    Vigh, J. P., Kincses, A., Ozgür, Burak, Walter, F. R., Santa-Maria, A. R., Valkai, S., Vastag, M., Neuhaus, W., Larsen, Birger Brodin, Dér, A. & Deli, M. A., 2021, In: Micromachines. 12, 6, 18 p., 685.

    Research output: Contribution to journal › Review › Research › peer-review

  9. 2020
  10. Published

    IPEC-J2 rMdr1a, a New Cell Line with Functional Expression of Rat P-glycoprotein Encoded by Rat Mdr1a for Drug Screening Purposes

    Saaby, Lasse, Trasborg, J., Rasmussen, M. A., Holst, B. & Larsen, Birger Brodin, 17 Jul 2020, In: Pharmaceutics. 12, 7, 17 p., 673.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Nitric oxide, KATP channels and endothelin-1 modulate brain pericyte function, vascular tone and neurovascular coupling

    Zambach, S. A., Cai, Changsi, Helms, H. C. C., Hald, B. O., Fordsmann, J. C., Nielsen, R. M., wbh615, wbh615, Larsen, Birger Brodin & Lauritzen, Martin, 8 Jun 2020, bioRxiv, 43 p.

    Research output: Working paper › Preprint › Research

  12. Published

    Culture of brain capillary pericytes for cytosolic calcium measurements and calcium imaging studies

    Hørlyck, S., Helms, H. C. C. & Larsen, Birger Brodin, May 2020, In: Journal of Visualized Experiments. 159, p. 1-9 9 p., e61253.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Culture-induced changes in mRNA expression levels of efflux and SLC-transporters in brain endothelial cells

    Goldeman, C., Ozgür, Burak & Larsen, Birger Brodin, 22 Apr 2020, In: Fluids and Barriers of the CNS. 17, 32, 12 p., 32.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    The Pyrazolo[3,4-d]pyrimidine Derivative, SCO-201, Reverses Multidrug Resistance Mediated by ABCG2/BCRP

    Ambjørner, S. E. B., Wiese, M., Köhler, S. C., Svindt, J., Lund, X. L., Gajhede, Michael, Saaby, Lasse, Larsen, Birger Brodin, Rump, S., Weigt, H., Brünner, N. & Stenvang, Jan, 4 Mar 2020, In: Cells. 9, 3, 22 p., 613.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    A novel derivative of thioridazine shows low toxicity and efficient activity against gram‐positive pathogens

    Jørgensen, N. S., Saaby, Lasse, Andersson, A. M., Kromann, Sofie, Sheikhsamani, E., Permin, A., Ronco, T., Svenningsen, Søren Wedel, Christensen, Jørn Bolstad & Olsen, Rikke Heidemann, 2020, In: Antibiotics. 9, 6, 11 p., 327.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Conjugation of Therapeutic PSD-95 Inhibitors to the Cell-Penetrating Peptide Tat Affects Blood-Brain Barrier Adherence, Uptake, and Permeation

    Kristensen, Mie, Kucharz, Krzysztof, Alves Fernandes, Eduardo Felipe, Strømgaard, Kristian, Schallburg Nielsen, M., Cederberg Helms, H. C., Bach, Anders, Ulrikkaholm Tofte-Hansen, M., Aldana, Blanca, Lauritzen, Martin & Larsen, Birger Brodin, 2020, In: Pharmaceutics. 12, 7, 24 p., 661.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Drug Delivery Strategies to Overcome the Blood-Brain Barrier (BBB)

    Helms, H. C. C., Kristensen, Mie, Saaby, Lasse, Fricker, G. & Larsen, Birger Brodin, 2020, Handbook of Experimental Pharmacology. Springer, Vol. 273. p. 151-183

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication

  18. Published

    Increased Carrier Peptide Stability through pH Adjustment Improves Insulin and PTH(1-34) Delivery In Vitro and In Vivo Rather than by Enforced Carrier Peptide-Cargo Complexation

    Kristensen, Mie, Diedrichsen, Ragna Guldsmed, Vetri, V., Foderà, Vito & Nielsen, Hanne Mørck, 2020, In: Pharmaceutics. 12, 10, 18 p., 993.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. 2019
  20. Published

    Effects of oxygen-glucose deprivation (OGD) on barrier properties and mRNA transcript levels of selected marker proteins in brain endothelial cells/astrocyte co-cultures

    Tornabene, E., Helms, H. C. C., Pedersen, Stine Helene Falsig & Larsen, Birger Brodin, 2019, In: PLoS ONE. 14, 8, 20 p., e0221103.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Evaluating the involvement of cerebral microvascular endothelial Na+/K+-ATPase and Na+-K+-2Cl- co-transporter in electrolyte fluxes in an in vitro blood-brain barrier model of dehydration

    Lykke, K., Assentoft, M., Hørlyck, S., Helms, H. C. C., Stoica, A., Toft-Bertelsen, Trine Lisberg, Tritsaris, Katerina, Vilhardt, Frederik, Larsen, Birger Brodin & MacAulay, Nanna, 2019, In: Journal of Cerebral Blood Flow and Metabolism. 39, 3, p. 497-512

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Two-photon fluorescence imaging: a platform to investigate cell-penetrating peptides and liposome-based nanocarriers for drug delivery across the heterogeneous BBB in vivo

    Kucharz, K., Kristensen, K., Kristensen, Mie, Lund, M., Andresen, T., Larsen, Birger Brodin & Lauritzen, M., 2019, In: Journal of Cerebral Blood Flow and Metabolism. 39, p. 60 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  23. 2018
  24. Published

    Validation of reference genes for normalization of real-time quantitative PCR studies of gene expression in brain capillary endothelial cells cultured in vitro

    Hersom, M., Goldeman, C., Pretzer, N. & Larsen, Birger Brodin, Dec 2018, In: Molecular and Cellular Neuroscience. 93, p. 27-35 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    The iP-gp cell model is an improved tool for predicting the in vivo relevance of P-gp mediated efflux at the blood-brain barrier

    Ozgür, Burak, Saaby, Lasse, Eneberg, E., Langthaler, K., Jacobsen, A., Janfelt, Christian, Badolo, L., Montanari, D. & Larsen, Birger Brodin, 22 Jun 2018.

    Research output: Contribution to conference › Poster › Research › peer-review

  26. Published

    Clinical and Regulatory Aspects of Companion Diagnostic Development in Oncology

    Jorgensen, J. T. & Hersom, M., Jun 2018, In: Clinical Pharmacology & Therapeutics. 103, 6, p. 999-1008

    Research output: Contribution to journal › Review › Research › peer-review

  27. Published

    Companion and Complementary Diagnostics-Focus on PD-L1 Expression Assays for PD-1/PD-L1 Checkpoint Inhibitors in Non-Small Cell Lung Cancer

    Hersom, M. & Jorgensen, J. T., Feb 2018, In: Therapeutic Drug Monitoring. 40, 1, p. 9-16

    Research output: Contribution to journal › Review › Research › peer-review

  28. Published

    Cellular effects and delivery propensity of penetratin is influenced by conjugation to parathyroid hormone fragment 1-34 in synergy with pH

    Kristensen, Mie, Nielsen, L. H., Zor, K., Boisen, A., Christensen, M. V., Berthelsen, J. & Nielsen, Hanne Mørck, 2018, In: Bioconjugate Chemistry. 29, 2, p. 371-381

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Characterization of the IPEC-J2 MDR1 (iP-gp) cell line as a tool for identification of P-gp substrates

    Ozgür, Burak, Saaby, Lasse, Langthaler, K. & Larsen, Birger Brodin, 2018, In: European Journal of Pharmaceutical Sciences. 112, p. 112-121 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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