- 2022
- Published
Highly cationic cell-penetrating peptides affect the barrier integrity and facilitates mannitol permeation in a human stem cell-based blood-brain barrier model
Frøslev, Patrick, Franzyk, Henrik, Ozgür, Burak, Larsen, Birger Brodin & Kristensen, Mie, 2022, In: European Journal of Pharmaceutical Sciences. 168, 10 p., 106054.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hypoxia increases expression of selected blood–brain barrier transporters GLUT-1, P-gp, SLC7A5 and TFRC, while maintaining barrier integrity, in brain capillary endothelial monolayers
Ozgür, Burak, Helms, H. C. C., Tornabene, E. & Larsen, Birger Brodin, 2022, In: Fluids and Barriers of the CNS. 19, 1, 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Physical and barrier changes in gastrointestinal mucus induced by the permeation enhancer sodium 8-[(2-hydroxybenzoyl)amino]octanoate (SNAC)
Mortensen, Janni Støvring, Bohr, S. S. R., Rønholt, Stine, Hatzakis, Nikos, Saaby, Lasse & Nielsen, Hanne Mørck, 2022, In: Journal of Controlled Release. 352, p. 163-178 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sortilin regulates blood-brain barrier integrity
Toth, A. E., Helms, H. C., Harazin, A., Johnsen, K. B., Goldeman, C., Burkhart, A., Thomsen, M. S., Kempen, P. J., Klepe, A., Lipka, D. V., Møller, P. L., Andresen, T. L., Nyegaard, M., Moos, T., Larsen, Birger Brodin & Nielsen, M. S., 2022, In: The FEBS Journal. 289, 4, p. 1062-1079Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tanycytes control hypothalamic liraglutide uptake and its anti-obesity actions
Imbernon, M., Saponaro, C., Helms, H. C. C., Duquenne, M., Fernandois, D., Deligia, E., Denis, R. G. P., Chao, D. H. M., Rasika, S., Staels, B., Pattou, F., Pfrieger, F. W., Larsen, Birger Brodin, Luquet, S., Bonner, C. & Prevot, V., 2022, In: Cell Metabolism. 34, 7, p. 1054-1063.e7Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Cell-Penetrating Peptide Tat Facilitates Effective Internalization of PSD-95 Inhibitors Into Blood–Brain Barrier Endothelial Cells but less Efficient Permeation Across the Blood–Brain Barrier In Vitro and In Vivo
Lisa Al Humaidan, E., Lund Pedersen, S., Burkhart, A., Laurfelt Munch Rasmussen, C., Moos, T., Fuchs, P., Alves Fernandes, E. F., Ozgür, Burak, Strømgaard, K., Bach, Anders, Larsen, Birger Brodin & Kristensen, Mie, 2022, In: Frontiers in Drug Delivery - CNS Drug Delivery. 2, 17 p., 854703.Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
Apicobasal transferrin receptor localization and trafficking in brain capillary endothelial cells
Nielsen, S. S. E., Holst, M. R., Langthaler, Kristine, Bruun, E. H., Larsen, Birger Brodin & Nielsen, M. S., 2023, In: Fluids and Barriers of the CNS. 20, 1, 15 p., 2.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Assessing extent of brain penetration in vivo (Kp,uu,brain) in Göttingen minipig using a diverse set of reference drugs
Langthaler, Kristine, Jones, C. R., Larsen, Birger Brodin & Bundgaard, C., 2023, In: European Journal of Pharmaceutical Sciences. 190, 11 p., 106554.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cell-Penetrating Peptides as Tools to Facilitate Oral Delivery of Biopharmaceuticals
Asgreen, Camilla Jantzen, Fredholt, Freja, Nielsen, Hanne Mørck & Kristensen, Mie, 2023, Cell-Penetrating Peptides: Design, Development and Applications. Oba, M. & Demizu, Y. (eds.). Wiley-VCH, p. 331-354Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Characterization of an iPSC-based barrier model for blood-brain barrier investigations using the SBAD0201 stem cell line
Ozgür, Burak, Puris, E., Brachner, A., Appelt-Menzel, A., Oerter, S., Balzer, V., Holst, M. R., Christiansen, R. F., Hyldig, K., Buckley, S. T., Kristensen, Mie, Auriola, S., Jensen, A., Fricker, G., Nielsen, M. S., Neuhaus, W. & Larsen, Birger Brodin, 2023, In: Fluids and Barriers of the CNS. 20, 1, 15 p., 96.Research output: Contribution to journal › Journal article › Research › peer-review
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200
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Data demonstrating the challenges of determining the kinetic parameters of P-gp mediated transport of low-water soluble substrates
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
173
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The Pyrazolo[3,4-d]pyrimidine Derivative, SCO-201, Reverses Multidrug Resistance Mediated by ABCG2/BCRP
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
105
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Effects of oxygen-glucose deprivation (OGD) on barrier properties and mRNA transcript levels of selected marker proteins in brain endothelial cells/astrocyte co-cultures
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Latest publications
Generation of an iPSC-line (BIONi010C-48) with restored P-glycoprotein functionality following transfection with the human MDR1 gene in the AAVS1 locus
Research output: Contribution to journal › Journal article › Research › peer-review
Neonatal intestinal mucus barrier changes in response to maturity, inflammation, and sodium decanoate supplementation
Research output: Contribution to journal › Journal article › Research › peer-review
The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier
Research output: Contribution to journal › Journal article › Research › peer-review