- Published
Hypoxia increases expression of selected blood–brain barrier transporters GLUT-1, P-gp, SLC7A5 and TFRC, while maintaining barrier integrity, in brain capillary endothelial monolayers
Ozgür, Burak, Helms, H. C. C., Tornabene, E. & Larsen, Birger Brodin, 2022, In: Fluids and Barriers of the CNS. 19, 1, 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Human induced pluripotent stem cells (BIONi010-C) generate tight cell monolayers with blood-brain barrier traits and functional expression of large neutral amino acid transporter 1 (SLC7A5)
Goldeman, C., Andersen, M., Al-Robai, A., Buchholtz, T., Svane, Nana Isabella, Ozgür, Burak, Holst, B., Shusta, E., Hall, Vanessa Jane, Saaby, Lasse, Hyttel, P. & Larsen, Birger Brodin, 2021, In: European Journal of Pharmaceutical Sciences. 156, 14 p., 105577.Research output: Contribution to journal › Journal article › Research › peer-review
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Highly cationic cell-penetrating peptides affect the barrier integrity and facilitates mannitol permeation in a human stem cell-based blood-brain barrier model
Frøslev, Patrick, Franzyk, Henrik, Ozgür, Burak, Larsen, Birger Brodin & Kristensen, Mie, 2022, In: European Journal of Pharmaceutical Sciences. 168, 10 p., 106054.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Gluten Degradation, Pharmacokinetics, Safety, and Tolerability of TAK-062, an Engineered Enzyme to Treat Celiac Disease
Pultz, I. S., Hill, M., Vitanza, J. M., Wolf, C., Saaby, Lasse, Liu, T., Winkle, P. & Leffler, D. A., Jul 2021, In: Gastroenterology. 161, 1, p. 81-93.e3Research output: Contribution to journal › Journal article › Research › peer-review
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Generation of transient and tunable oxygen gradients in microfluidic channels utilizing the oxygen scavenging properties of thiol-ene polymers
Yuan, Z., Sticker, Drago, Helms, H. C. C. & Kutter, Jörg P., 2022, In: Microfluidics and Nanofluidics. 26, 6, 10 p., 42.Research output: Contribution to journal › Journal article › Research › peer-review
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Generation of primary cultures of bovine brain endothelial cells and setup of cocultures with rat astrocytes
Helms, H. C. & Larsen, Birger Brodin, 2014, In: Methods in molecular biology (Clifton, N.J.). 1135, p. 365-82 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Generation of an iPSC-line (BIONi010C-48) with restored P-glycoprotein functionality following transfection with the human MDR1 gene in the AAVS1 locus
Nielsen, A. K. R., Lilieholm-Røngren, L., Schmid, B., Holst, B., Larsen, Birger Brodin & Saaby, Lasse, 2024, In: Stem Cell Research. 76, 5 p., 103348.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evidence for P2Y-type ATP receptors on the serosal membrane of frog skin epithelium
Larsen, Birger Brodin & Nielsen, R., 1 Jan 2000, In: Pflugers Archiv European Journal of Physiology. 439, 3, p. 234-239 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evaluating the involvement of cerebral microvascular endothelial Na+/K+-ATPase and Na+-K+-2Cl- co-transporter in electrolyte fluxes in an in vitro blood-brain barrier model of dehydration
Lykke, K., Assentoft, M., Hørlyck, S., Helms, H. C. C., Stoica, A., Toft-Bertelsen, Trine Lisberg, Tritsaris, Katerina, Vilhardt, Frederik, Larsen, Birger Brodin & MacAulay, Nanna, 2019, In: Journal of Cerebral Blood Flow and Metabolism. 39, 3, p. 497-512Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Epithelium dynamics differ in time and space when exposed to the permeation enhancers penetramax and EGTA. A head-to-head mechanistic comparison
Panou, D. A., Pedersen, Stine Helene Falsig, Kristensen, Mie & Nielsen, Hanne Mørck, 2023, In: Frontiers in Drug Delivery. 3, 16 p., 1221628.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
En af hjernens forsvarsmure: Blod-hjerne-barrieren
Ozgür, Burak, 2022, In: Pharma. 2022, 4, p. 15-17Research output: Contribution to journal › Contribution to newspaper - Newspaper article › Communication
- Published
Effects of oxygen-glucose deprivation (OGD) on barrier properties and mRNA transcript levels of selected marker proteins in brain endothelial cells/astrocyte co-cultures
Tornabene, E., Helms, H. C. C., Pedersen, Stine Helene Falsig & Larsen, Birger Brodin, 2019, In: PLoS ONE. 14, 8, 20 p., e0221103.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Drug Delivery Strategies to Overcome the Blood-Brain Barrier (BBB)
Helms, H. C. C., Kristensen, Mie, Saaby, Lasse, Fricker, G. & Larsen, Birger Brodin, 2020, Handbook of Experimental Pharmacology. Springer, Vol. 273. p. 151-183Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication
- Published
Data demonstrating the challenges of determining the kinetic parameters of P-gp mediated transport of low-water soluble substrates
Ozgür, Burak, Saaby, Lasse, Langthaler, K. & Larsen, Birger Brodin, 2018, In: Data in Brief. 16, p. 655-659 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Culture-induced changes in mRNA expression levels of efflux and SLC-transporters in brain endothelial cells
Goldeman, C., Ozgür, Burak & Larsen, Birger Brodin, 22 Apr 2020, In: Fluids and Barriers of the CNS. 17, 32, 12 p., 32.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Culture of brain capillary pericytes for cytosolic calcium measurements and calcium imaging studies
Hørlyck, S., Helms, H. C. C. & Larsen, Birger Brodin, May 2020, In: Journal of Visualized Experiments. 159, p. 1-9 9 p., e61253.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Considerations regarding use of solvents in in vitro cell based assays
Timm, M., Saaby, Lasse, Moesby, L. & Hansen, E. W., Oct 2013, In: Cytotechnology. 65, 5, p. 887-894 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conjugation of Therapeutic PSD-95 Inhibitors to the Cell-Penetrating Peptide Tat Affects Blood-Brain Barrier Adherence, Uptake, and Permeation
Kristensen, Mie, Kucharz, Krzysztof, Alves Fernandes, Eduardo Felipe, Strømgaard, Kristian, Schallburg Nielsen, M., Cederberg Helms, H. C., Bach, Anders, Ulrikkaholm Tofte-Hansen, M., Aldana, Blanca, Lauritzen, Martin & Larsen, Birger Brodin, 2020, In: Pharmaceutics. 12, 7, 24 p., 661.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Companion and Complementary Diagnostics-Focus on PD-L1 Expression Assays for PD-1/PD-L1 Checkpoint Inhibitors in Non-Small Cell Lung Cancer
Hersom, M. & Jorgensen, J. T., Feb 2018, In: Therapeutic Drug Monitoring. 40, 1, p. 9-16Research output: Contribution to journal › Review › Research › peer-review
- Published
Clinical and Regulatory Aspects of Companion Diagnostic Development in Oncology
Jorgensen, J. T. & Hersom, M., Jun 2018, In: Clinical Pharmacology & Therapeutics. 103, 6, p. 999-1008Research output: Contribution to journal › Review › Research › peer-review
- Published
Characterization of the IPEC-J2 MDR1 (iP-gp) cell line as a tool for identification of P-gp substrates
Ozgür, Burak, Saaby, Lasse, Langthaler, K. & Larsen, Birger Brodin, 2018, In: European Journal of Pharmaceutical Sciences. 112, p. 112-121 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of an iPSC-based barrier model for blood-brain barrier investigations using the SBAD0201 stem cell line
Ozgür, Burak, Puris, E., Brachner, A., Appelt-Menzel, A., Oerter, S., Balzer, V., Holst, M. R., Christiansen, R. F., Hyldig, K., Buckley, S. T., Kristensen, Mie, Auriola, S., Jensen, A., Fricker, G., Nielsen, M. S., Neuhaus, W. & Larsen, Birger Brodin, 2023, In: Fluids and Barriers of the CNS. 20, 1, 15 p., 96.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterisation of intravenous pharmacokinetics in Göttingen minipig and clearance prediction using established in vitro to in vivo extrapolation methodologies
Langthaler, Kristine, Jones, C. R., Christensen, R. B., Eneberg, E., Larsen, Birger Brodin & Bundgaard, C., 2022, In: Xenobiotica. 52, 6, p. 591-607Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cellular effects and delivery propensity of penetratin is influenced by conjugation to parathyroid hormone fragment 1-34 in synergy with pH
Kristensen, Mie, Nielsen, L. H., Zor, K., Boisen, A., Christensen, M. V., Berthelsen, J. & Nielsen, Hanne Mørck, 2018, In: Bioconjugate Chemistry. 29, 2, p. 371-381Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cell-penetrating peptides as carriers for transepithelial drug delivery in vitro
Rønholt, Stine, Kristensen, Mie & Nielsen, Hanne Mørck, 2015, In: Methods in Molecular Biology. 1324, p. 261-277 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Data demonstrating the challenges of determining the kinetic parameters of P-gp mediated transport of low-water soluble substrates
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The Pyrazolo[3,4-d]pyrimidine Derivative, SCO-201, Reverses Multidrug Resistance Mediated by ABCG2/BCRP
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Effects of oxygen-glucose deprivation (OGD) on barrier properties and mRNA transcript levels of selected marker proteins in brain endothelial cells/astrocyte co-cultures
Research output: Contribution to journal › Journal article › Research › peer-review
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Generation of an iPSC-line (BIONi010C-48) with restored P-glycoprotein functionality following transfection with the human MDR1 gene in the AAVS1 locus
Research output: Contribution to journal › Journal article › Research › peer-review
Neonatal intestinal mucus barrier changes in response to maturity, inflammation, and sodium decanoate supplementation
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The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier
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