- Published
Apicobasal transferrin receptor localization and trafficking in brain capillary endothelial cells
Nielsen, S. S. E., Holst, M. R., Langthaler, Kristine, Bruun, E. H., Larsen, Birger Brodin & Nielsen, M. S., 2023, In: Fluids and Barriers of the CNS. 20, 1, 15 p., 2.Research output: Contribution to journal › Journal article › Research › peer-review
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Generation of an iPSC-line (BIONi010C-48) with restored P-glycoprotein functionality following transfection with the human MDR1 gene in the AAVS1 locus
Nielsen, A. K. R., Lilieholm-Røngren, L., Schmid, B., Holst, B., Larsen, Birger Brodin & Saaby, Lasse, 2024, In: Stem Cell Research. 76, 5 p., 103348.Research output: Contribution to journal › Journal article › Research › peer-review
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Neonatal intestinal mucus barrier changes in response to maturity, inflammation, and sodium decanoate supplementation
Mortensen, Janni Støvring, Bohr, S. S. R., Krog, Lasse Skjoldborg, Bøtker, Johan Peter, Kapousidou, V., Saaby, Lasse, Hatzakis, Nikos, Nielsen, Hanne Mørck, Nguyen, Duc Ninh & Rønholt, Stine, 2024, In: Scientific Reports. 14, 1, 17 p., 7665.Research output: Contribution to journal › Journal article › Research › peer-review
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Physical and barrier changes in gastrointestinal mucus induced by the permeation enhancer sodium 8-[(2-hydroxybenzoyl)amino]octanoate (SNAC)
Mortensen, Janni Støvring, Bohr, S. S. R., Rønholt, Stine, Hatzakis, Nikos, Saaby, Lasse & Nielsen, Hanne Mørck, 2022, In: Journal of Controlled Release. 352, p. 163-178 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Evaluating the involvement of cerebral microvascular endothelial Na+/K+-ATPase and Na+-K+-2Cl- co-transporter in electrolyte fluxes in an in vitro blood-brain barrier model of dehydration
Lykke, K., Assentoft, M., Hørlyck, S., Helms, H. C. C., Stoica, A., Toft-Bertelsen, Trine Lisberg, Tritsaris, Katerina, Vilhardt, Frederik, Larsen, Birger Brodin & MacAulay, Nanna, 2019, In: Journal of Cerebral Blood Flow and Metabolism. 39, 3, p. 497-512Research output: Contribution to journal › Journal article › Research › peer-review
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The Cell-Penetrating Peptide Tat Facilitates Effective Internalization of PSD-95 Inhibitors Into Blood–Brain Barrier Endothelial Cells but less Efficient Permeation Across the Blood–Brain Barrier In Vitro and In Vivo
Lisa Al Humaidan, E., Lund Pedersen, S., Burkhart, A., Laurfelt Munch Rasmussen, C., Moos, T., Fuchs, P., Alves Fernandes, E. F., Ozgür, Burak, Strømgaard, K., Bach, Anders, Larsen, Birger Brodin & Kristensen, Mie, 2022, In: Frontiers in Drug Delivery - CNS Drug Delivery. 2, 17 p., 854703.Research output: Contribution to journal › Journal article › Research › peer-review
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Application of a new MDCKII-MDR1 cell model to measure the extent of drug distribution in vitro at equilibrium for prediction of in vivo unbound brain-to-plasma drug distribution
Langthaler, Kristine, Jones, C. R., Saaby, Lasse, Bundgaard, C. & Larsen, Birger Brodin, 2024, In: Fluids and Barriers of the CNS. 21, 1, 15 p., 11.Research output: Contribution to journal › Journal article › Research › peer-review
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Assessing extent of brain penetration in vivo (Kp,uu,brain) in Göttingen minipig using a diverse set of reference drugs
Langthaler, Kristine, Jones, C. R., Larsen, Birger Brodin & Bundgaard, C., 2023, In: European Journal of Pharmaceutical Sciences. 190, 11 p., 106554.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterisation of intravenous pharmacokinetics in Göttingen minipig and clearance prediction using established in vitro to in vivo extrapolation methodologies
Langthaler, Kristine, Jones, C. R., Christensen, R. B., Eneberg, E., Larsen, Birger Brodin & Bundgaard, C., 2022, In: Xenobiotica. 52, 6, p. 591-607Research output: Contribution to journal › Journal article › Research › peer-review
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The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier
Kurtyka, M., Wessely, F., Bau, S., Ifie, E., He, L., de Wit, N. M., Pedersen, A. B. V., Keller, M., Webber, C., de Vries, H. E., Ansorge, O., Betsholtz, C., De Bock, M., Chaves, C., Brodin, B., Nielsen, M. S., Neuhaus, W., Bell, R. D., Letoha, T., Meyer, A. H. & 7 others, , 2024, In: European Journal of Cell Biology. 103, 2, 14 p., 151406.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Two-photon fluorescence imaging: a platform to investigate cell-penetrating peptides and liposome-based nanocarriers for drug delivery across the heterogeneous BBB in vivo
Kucharz, K., Kristensen, K., Kristensen, Mie, Lund, M., Andresen, T., Larsen, Birger Brodin & Lauritzen, M., 2019, In: Journal of Cerebral Blood Flow and Metabolism. 39, p. 60 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Cellular effects and delivery propensity of penetratin is influenced by conjugation to parathyroid hormone fragment 1-34 in synergy with pH
Kristensen, Mie, Nielsen, L. H., Zor, K., Boisen, A., Christensen, M. V., Berthelsen, J. & Nielsen, Hanne Mørck, 2018, In: Bioconjugate Chemistry. 29, 2, p. 371-381Research output: Contribution to journal › Journal article › Research › peer-review
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Conjugation of Therapeutic PSD-95 Inhibitors to the Cell-Penetrating Peptide Tat Affects Blood-Brain Barrier Adherence, Uptake, and Permeation
Kristensen, Mie, Kucharz, Krzysztof, Alves Fernandes, Eduardo Felipe, Strømgaard, Kristian, Schallburg Nielsen, M., Cederberg Helms, H. C., Bach, Anders, Ulrikkaholm Tofte-Hansen, M., Aldana, Blanca, Lauritzen, Martin & Larsen, Birger Brodin, 2020, In: Pharmaceutics. 12, 7, 24 p., 661.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Increased Carrier Peptide Stability through pH Adjustment Improves Insulin and PTH(1-34) Delivery In Vitro and In Vivo Rather than by Enforced Carrier Peptide-Cargo Complexation
Kristensen, Mie, Diedrichsen, Ragna Guldsmed, Vetri, V., Foderà, Vito & Nielsen, Hanne Mørck, 2020, In: Pharmaceutics. 12, 10, 18 p., 993.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A novel derivative of thioridazine shows low toxicity and efficient activity against gram‐positive pathogens
Jørgensen, N. S., Saaby, Lasse, Andersson, A. M., Kromann, Sofie, Sheikhsamani, E., Permin, A., Ronco, T., Svenningsen, Søren Wedel, Christensen, Jørn Bolstad & Olsen, Rikke Heidemann, 2020, In: Antibiotics. 9, 6, 11 p., 327.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Clinical and Regulatory Aspects of Companion Diagnostic Development in Oncology
Jorgensen, J. T. & Hersom, M., Jun 2018, In: Clinical Pharmacology & Therapeutics. 103, 6, p. 999-1008Research output: Contribution to journal › Review › Research › peer-review
- Published
Tanycytes control hypothalamic liraglutide uptake and its anti-obesity actions
Imbernon, M., Saponaro, C., Helms, H. C. C., Duquenne, M., Fernandois, D., Deligia, E., Denis, R. G. P., Chao, D. H. M., Rasika, S., Staels, B., Pattou, F., Pfrieger, F. W., Larsen, Birger Brodin, Luquet, S., Bonner, C. & Prevot, V., 2022, In: Cell Metabolism. 34, 7, p. 1054-1063.e7Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tanycytes Control the Hypothalamic Uptake and Metabolic Actions of Liraglutide
Imbernon, M., Saponaro, C., Helms, H. C. C., Zubiaga, L., Bitsi, S., Duquenne, M., Tomas, A., Chen, S., Salem, V., Deligia, E., Gmyr, V., Denis, R., Kerr-Conte, J., Chao, D. H. M., Beiroa, D., Steals, B., Pattou, F., Pfrieger, F., Brodin, B., Jones, B. & 3 others, , Jul 2021, In: Glia. 69, S1, p. E237-E237Research output: Contribution to journal › Conference abstract in journal › Research
- Published
ATP induces contraction of cultured brain capillary pericytes, via activation of P2Y type purinergic receptors
Hørlyck, S., Cai, Changsi, Helms, H. C., Lauritzen, Martin & Larsen, Birger Brodin, 2021, In: American Journal of Physiology: Heart and Circulatory Physiology. 320, p. H699–H712 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Culture of brain capillary pericytes for cytosolic calcium measurements and calcium imaging studies
Hørlyck, S., Helms, H. C. C. & Larsen, Birger Brodin, May 2020, In: Journal of Visualized Experiments. 159, p. 1-9 9 p., e61253.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Subcellular trafficking and transcytosis efficacy of different receptor types for therapeutic antibody delivery at the blood‒brain barrier
Holst, M. R., de Wit, N. M., Ozgür, Burak, Brachner, A., Hyldig, K., Appelt-Menzel, A., Sleven, H., Cader, Z., de Vries, H. E., Neuhaus, W., Jensen, A., Larsen, Birger Brodin & Nielsen, M. S., 2023, In: Fluids and Barriers of the CNS. 20, 1, 17 p., 82.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Brain endothelial cells metabolize glutamate via glutamate dehydrogenase to replenish TCA-intermediates and produce ATP under hypoglycemic conditions
Hinca, S. B., Salcedo, C., Wagner, A., Goldeman, C., Sadat, E., Aibar, M. M. D., Maechler, P., Larsen, Birger Brodin, Aldana, Blanca & Helms, H. C. C., 2021, In: Journal of Neurochemistry. 157, 6, p. 1861-1875Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The insulin receptor is expressed and functional in cultured blood-brain barrier endothelial cells, but does not mediate insulin entry from blood-to-brain
Hersom, M., Helms, H. C., Schmalz, C., Pedersen, T. Å., Buckley, S. T. & Larsen, Birger Brodin, 2018, In: American Journal of Physiology: Endocrinology and Metabolism. 315, 4, p. E531-E542Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Companion and Complementary Diagnostics-Focus on PD-L1 Expression Assays for PD-1/PD-L1 Checkpoint Inhibitors in Non-Small Cell Lung Cancer
Hersom, M. & Jorgensen, J. T., Feb 2018, In: Therapeutic Drug Monitoring. 40, 1, p. 9-16Research output: Contribution to journal › Review › Research › peer-review
- Published
Validation of reference genes for normalization of real-time quantitative PCR studies of gene expression in brain capillary endothelial cells cultured in vitro
Hersom, M., Goldeman, C., Pretzer, N. & Larsen, Birger Brodin, Dec 2018, In: Molecular and Cellular Neuroscience. 93, p. 27-35 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Data demonstrating the challenges of determining the kinetic parameters of P-gp mediated transport of low-water soluble substrates
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176
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The Pyrazolo[3,4-d]pyrimidine Derivative, SCO-201, Reverses Multidrug Resistance Mediated by ABCG2/BCRP
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Effects of oxygen-glucose deprivation (OGD) on barrier properties and mRNA transcript levels of selected marker proteins in brain endothelial cells/astrocyte co-cultures
Research output: Contribution to journal › Journal article › Research › peer-review
Published
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Generation of an iPSC-line (BIONi010C-48) with restored P-glycoprotein functionality following transfection with the human MDR1 gene in the AAVS1 locus
Research output: Contribution to journal › Journal article › Research › peer-review
Neonatal intestinal mucus barrier changes in response to maturity, inflammation, and sodium decanoate supplementation
Research output: Contribution to journal › Journal article › Research › peer-review
The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier
Research output: Contribution to journal › Journal article › Research › peer-review