Utilizing Laser Activation of Photothermal Plasmonic Nanoparticles to Induce On-Demand Drug Amorphization inside a Tablet

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Utilizing Laser Activation of Photothermal Plasmonic Nanoparticles to Induce On-Demand Drug Amorphization inside a Tablet. / Hempel, Nele Johanna; Merkl, Padryk; Asad, Shno; Knopp, Matthias Manne; Berthelsen, Ragna; Bergström, Christel A.S.; Teleki, Alexandra; Sotiriou, Georgios A.; Löbmann, Korbinian.

In: Molecular Pharmaceutics, Vol. 18, No. 6, 2021, p. 2254–2262.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hempel, NJ, Merkl, P, Asad, S, Knopp, MM, Berthelsen, R, Bergström, CAS, Teleki, A, Sotiriou, GA & Löbmann, K 2021, 'Utilizing Laser Activation of Photothermal Plasmonic Nanoparticles to Induce On-Demand Drug Amorphization inside a Tablet', Molecular Pharmaceutics, vol. 18, no. 6, pp. 2254–2262. https://doi.org/10.1021/acs.molpharmaceut.1c00077

APA

Hempel, N. J., Merkl, P., Asad, S., Knopp, M. M., Berthelsen, R., Bergström, C. A. S., Teleki, A., Sotiriou, G. A., & Löbmann, K. (2021). Utilizing Laser Activation of Photothermal Plasmonic Nanoparticles to Induce On-Demand Drug Amorphization inside a Tablet. Molecular Pharmaceutics, 18(6), 2254–2262. https://doi.org/10.1021/acs.molpharmaceut.1c00077

Vancouver

Hempel NJ, Merkl P, Asad S, Knopp MM, Berthelsen R, Bergström CAS et al. Utilizing Laser Activation of Photothermal Plasmonic Nanoparticles to Induce On-Demand Drug Amorphization inside a Tablet. Molecular Pharmaceutics. 2021;18(6):2254–2262. https://doi.org/10.1021/acs.molpharmaceut.1c00077

Author

Hempel, Nele Johanna ; Merkl, Padryk ; Asad, Shno ; Knopp, Matthias Manne ; Berthelsen, Ragna ; Bergström, Christel A.S. ; Teleki, Alexandra ; Sotiriou, Georgios A. ; Löbmann, Korbinian. / Utilizing Laser Activation of Photothermal Plasmonic Nanoparticles to Induce On-Demand Drug Amorphization inside a Tablet. In: Molecular Pharmaceutics. 2021 ; Vol. 18, No. 6. pp. 2254–2262.

Bibtex

@article{d1ffd1d1d3654fbf8738e4ba206ffacf,

title = "Utilizing Laser Activation of Photothermal Plasmonic Nanoparticles to Induce On-Demand Drug Amorphization inside a Tablet",

abstract = "Poor aqueous drug solubility represents a major challenge in oral drug delivery. A novel approach to overcome this challenge is drug amorphization inside a tablet, that is, on-demand drug amorphization. The amorphous form is a thermodynamically instable, disordered solid-state with increased dissolution rate and solubility compared to its crystalline counterpart. During on-demand drug amorphization, the drug molecularly disperses into a polymer to form an amorphous solid at elevated temperatures inside a tablet. This study investigates, for the first time, the utilization of photothermal plasmonic nanoparticles for on-demand drug amorphization as a new pharmaceutical application. For this, near-IR photothermal plasmonic nanoparticles were tableted together with a crystalline drug (celecoxib) and a polymer (polyvinylpyrrolidone). The tablets were subjected to a near-IR laser at different intensities and durations to study the rate of drug amorphization under each condition. During laser irradiation, the plasmonic nanoparticles homogeneously heated the tablet. The temperature was directly related to the rate and degree of amorphization. Exposure times as low as 180 s at 1.12 W cm-2 laser intensity with only 0.25 wt % plasmonic nanoparticles and up to 50 wt % drug load resulted in complete drug amorphization. Therefore, near-IR photothermal plasmonic nanoparticles are promising excipients for on-demand drug amorphization with laser irradiation.",

keywords = "amorphous solid dispersions, in situ drug amorphization, near-IR laser irradiation, plasmonic nanoaggregates",

author = "Hempel, {Nele Johanna} and Padryk Merkl and Shno Asad and Knopp, {Matthias Manne} and Ragna Berthelsen and Bergstr{\"o}m, {Christel A.S.} and Alexandra Teleki and Sotiriou, {Georgios A.} and Korbinian L{\"o}bmann",

year = "2021",

doi = "10.1021/acs.molpharmaceut.1c00077",

language = "English",

volume = "18",

pages = "2254–2262",

journal = "Molecular Pharmaceutics",

issn = "1543-8384",

publisher = "American Chemical Society",

number = "6",

}

RIS

TY - JOUR

T1 - Utilizing Laser Activation of Photothermal Plasmonic Nanoparticles to Induce On-Demand Drug Amorphization inside a Tablet

AU - Hempel, Nele Johanna

AU - Merkl, Padryk

AU - Asad, Shno

AU - Knopp, Matthias Manne

AU - Berthelsen, Ragna

AU - Bergström, Christel A.S.

AU - Teleki, Alexandra

AU - Sotiriou, Georgios A.

AU - Löbmann, Korbinian

PY - 2021

Y1 - 2021

N2 - Poor aqueous drug solubility represents a major challenge in oral drug delivery. A novel approach to overcome this challenge is drug amorphization inside a tablet, that is, on-demand drug amorphization. The amorphous form is a thermodynamically instable, disordered solid-state with increased dissolution rate and solubility compared to its crystalline counterpart. During on-demand drug amorphization, the drug molecularly disperses into a polymer to form an amorphous solid at elevated temperatures inside a tablet. This study investigates, for the first time, the utilization of photothermal plasmonic nanoparticles for on-demand drug amorphization as a new pharmaceutical application. For this, near-IR photothermal plasmonic nanoparticles were tableted together with a crystalline drug (celecoxib) and a polymer (polyvinylpyrrolidone). The tablets were subjected to a near-IR laser at different intensities and durations to study the rate of drug amorphization under each condition. During laser irradiation, the plasmonic nanoparticles homogeneously heated the tablet. The temperature was directly related to the rate and degree of amorphization. Exposure times as low as 180 s at 1.12 W cm-2 laser intensity with only 0.25 wt % plasmonic nanoparticles and up to 50 wt % drug load resulted in complete drug amorphization. Therefore, near-IR photothermal plasmonic nanoparticles are promising excipients for on-demand drug amorphization with laser irradiation.

AB - Poor aqueous drug solubility represents a major challenge in oral drug delivery. A novel approach to overcome this challenge is drug amorphization inside a tablet, that is, on-demand drug amorphization. The amorphous form is a thermodynamically instable, disordered solid-state with increased dissolution rate and solubility compared to its crystalline counterpart. During on-demand drug amorphization, the drug molecularly disperses into a polymer to form an amorphous solid at elevated temperatures inside a tablet. This study investigates, for the first time, the utilization of photothermal plasmonic nanoparticles for on-demand drug amorphization as a new pharmaceutical application. For this, near-IR photothermal plasmonic nanoparticles were tableted together with a crystalline drug (celecoxib) and a polymer (polyvinylpyrrolidone). The tablets were subjected to a near-IR laser at different intensities and durations to study the rate of drug amorphization under each condition. During laser irradiation, the plasmonic nanoparticles homogeneously heated the tablet. The temperature was directly related to the rate and degree of amorphization. Exposure times as low as 180 s at 1.12 W cm-2 laser intensity with only 0.25 wt % plasmonic nanoparticles and up to 50 wt % drug load resulted in complete drug amorphization. Therefore, near-IR photothermal plasmonic nanoparticles are promising excipients for on-demand drug amorphization with laser irradiation.

KW - amorphous solid dispersions

KW - in situ drug amorphization

KW - near-IR laser irradiation

KW - plasmonic nanoaggregates

U2 - 10.1021/acs.molpharmaceut.1c00077

DO - 10.1021/acs.molpharmaceut.1c00077

M3 - Journal article

C2 - 33951909

AN - SCOPUS:85106503744

VL - 18

SP - 2254

EP - 2262

JO - Molecular Pharmaceutics

JF - Molecular Pharmaceutics

SN - 1543-8384

IS - 6

ER -

ID: 273634612

Department of Pharmacy