Two new antiprotozoal 5-methylcoumarins from Vernonia brachycalyx

Research output: Contribution to journalJournal articleResearchpeer-review

Two new isomeric 5-methylcoumarins, 2'-epicycloisobrachycoumarinone epoxide (1) and cycloisobrachycoumarinone epoxide (2), have been isolated from the roots of Vernonia brachycalyx by means of bioactivity-guided fractionation. The structures were elucidated by MS and NMR spectroscopic methods. Compounds 1 and 2 showed in vitro activity against Leishmania major promastigotes and against Plasmodium falciparum schizonts and demonstrated an inhibition on the proliferation of human lymphocytes, which was significantly weaker than the antiparasitic effects.
Original languageEnglish
JournalJournal of Natural Products
Issue number5
Pages (from-to)458-61
Number of pages3
Publication statusPublished - 1997

Bibliographical note

Keywords: Animals; Antimalarials; Antiprotozoal Agents; Coumarins; Furans; Leishmania major; Lymphocyte Activation; Magnetic Resonance Spectroscopy; Plant Roots; Plants, Medicinal; Plasmodium falciparum

ID: 6766230