Two new antiprotozoal 5-methylcoumarins from Vernonia brachycalyx

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Two new antiprotozoal 5-methylcoumarins from Vernonia brachycalyx. / Oketch-Rabah, H A; Lemmich, E; Dossaji, S F; Theander, T G; Olsen, C E; Cornett, C; Kharazmi, A; Christensen, S B.

In: Journal of Natural Products, Vol. 60, No. 5, 1997, p. 458-61.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Oketch-Rabah, HA, Lemmich, E, Dossaji, SF, Theander, TG, Olsen, CE, Cornett, C, Kharazmi, A & Christensen, SB 1997, 'Two new antiprotozoal 5-methylcoumarins from Vernonia brachycalyx', Journal of Natural Products, vol. 60, no. 5, pp. 458-61. https://doi.org/10.1021/np970030o

APA

Oketch-Rabah, H. A., Lemmich, E., Dossaji, S. F., Theander, T. G., Olsen, C. E., Cornett, C., Kharazmi, A., & Christensen, S. B. (1997). Two new antiprotozoal 5-methylcoumarins from Vernonia brachycalyx. Journal of Natural Products, 60(5), 458-61. https://doi.org/10.1021/np970030o

Vancouver

Oketch-Rabah HA, Lemmich E, Dossaji SF, Theander TG, Olsen CE, Cornett C et al. Two new antiprotozoal 5-methylcoumarins from Vernonia brachycalyx. Journal of Natural Products. 1997;60(5):458-61. https://doi.org/10.1021/np970030o

Author

Oketch-Rabah, H A ; Lemmich, E ; Dossaji, S F ; Theander, T G ; Olsen, C E ; Cornett, C ; Kharazmi, A ; Christensen, S B. / Two new antiprotozoal 5-methylcoumarins from Vernonia brachycalyx. In: Journal of Natural Products. 1997 ; Vol. 60, No. 5. pp. 458-61.

Bibtex

@article{465f6ff0a0d911dd86a6000ea68e967b,
title = "Two new antiprotozoal 5-methylcoumarins from Vernonia brachycalyx",
abstract = "Two new isomeric 5-methylcoumarins, 2'-epicycloisobrachycoumarinone epoxide (1) and cycloisobrachycoumarinone epoxide (2), have been isolated from the roots of Vernonia brachycalyx by means of bioactivity-guided fractionation. The structures were elucidated by MS and NMR spectroscopic methods. Compounds 1 and 2 showed in vitro activity against Leishmania major promastigotes and against Plasmodium falciparum schizonts and demonstrated an inhibition on the proliferation of human lymphocytes, which was significantly weaker than the antiparasitic effects.",
author = "Oketch-Rabah, {H A} and E Lemmich and Dossaji, {S F} and Theander, {T G} and Olsen, {C E} and C Cornett and A Kharazmi and Christensen, {S B}",
note = "Keywords: Animals; Antimalarials; Antiprotozoal Agents; Coumarins; Furans; Leishmania major; Lymphocyte Activation; Magnetic Resonance Spectroscopy; Plant Roots; Plants, Medicinal; Plasmodium falciparum",
year = "1997",
doi = "10.1021/np970030o",
language = "English",
volume = "60",
pages = "458--61",
journal = "Journal of Natural Products",
issn = "0163-3864",
publisher = "American Chemical Society",
number = "5",

}

RIS

TY - JOUR

T1 - Two new antiprotozoal 5-methylcoumarins from Vernonia brachycalyx

AU - Oketch-Rabah, H A

AU - Lemmich, E

AU - Dossaji, S F

AU - Theander, T G

AU - Olsen, C E

AU - Cornett, C

AU - Kharazmi, A

AU - Christensen, S B

N1 - Keywords: Animals; Antimalarials; Antiprotozoal Agents; Coumarins; Furans; Leishmania major; Lymphocyte Activation; Magnetic Resonance Spectroscopy; Plant Roots; Plants, Medicinal; Plasmodium falciparum

PY - 1997

Y1 - 1997

N2 - Two new isomeric 5-methylcoumarins, 2'-epicycloisobrachycoumarinone epoxide (1) and cycloisobrachycoumarinone epoxide (2), have been isolated from the roots of Vernonia brachycalyx by means of bioactivity-guided fractionation. The structures were elucidated by MS and NMR spectroscopic methods. Compounds 1 and 2 showed in vitro activity against Leishmania major promastigotes and against Plasmodium falciparum schizonts and demonstrated an inhibition on the proliferation of human lymphocytes, which was significantly weaker than the antiparasitic effects.

AB - Two new isomeric 5-methylcoumarins, 2'-epicycloisobrachycoumarinone epoxide (1) and cycloisobrachycoumarinone epoxide (2), have been isolated from the roots of Vernonia brachycalyx by means of bioactivity-guided fractionation. The structures were elucidated by MS and NMR spectroscopic methods. Compounds 1 and 2 showed in vitro activity against Leishmania major promastigotes and against Plasmodium falciparum schizonts and demonstrated an inhibition on the proliferation of human lymphocytes, which was significantly weaker than the antiparasitic effects.

U2 - 10.1021/np970030o

DO - 10.1021/np970030o

M3 - Journal article

C2 - 9170288

VL - 60

SP - 458

EP - 461

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

IS - 5

ER -

ID: 6766230