Transdermal delivery of hydrophobic and hydrophilic local anesthetics from o/w and w/o Brij 97-based microemulsions

Research output: Contribution to journalJournal articleResearchpeer-review

  • Varaporn Buraphacheep Junyaprasert
  • Prapaporn Boonme
  • Sarunyoo Songkro
  • Karen Krauel
  • Rades, Thomas
To characterize the physicochemical properties of drug-loaded oil-in-water (o/w) and water-in-oil (w/o) Brij 97-based microemulsions in comparison to their blank counterparts and to investigate the influence of microemulsion type on in vitro skin permeation of model hydrophobic drugs and their hydrophilic salts.
Original languageEnglish
JournalJournal of Pharmacy and Pharmaceutical Sciences
Issue number3
Pages (from-to)288-98
Number of pages11
Publication statusPublished - 2007

    Research areas

  • 1-Butanol, Administration, Cutaneous, Anesthetics, Local, Calorimetry, Differential Scanning, Dibucaine, Electric Conductivity, Emulsions, Epidermis, Humans, Hydrogen-Ion Concentration, Hydrophobic and Hydrophilic Interactions, Lidocaine, Molecular Weight, Palmitates, Permeability, Plant Oils, Polyethylene Glycols, Skin Absorption, Tetracaine, Viscosity, Water

ID: 40354169