Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems

Research output: Contribution to journalJournal articleResearchpeer-review


  • Ben J. Boyd
  • Christel A.S. Bergström
  • Zahari Vinarov
  • Martin Kuentz
  • Joachim Brouwers
  • Patrick Augustijns
  • Martin Brandl
  • Andreas Bernkop-Schnürch
  • Neha Shrestha
  • Véronique Préat
  • Müllertz, Anette
  • Annette Bauer-Brandl
  • Vincent Jannin

Poorly water-soluble drugs continue to be a problematic, yet important class of pharmaceutical compounds for treatment of a wide range of diseases. Their prevalence in discovery is still high, and their development is usually limited by our lack of a complete understanding of how the complex chemical, physiological and biochemical processes that occur between administration and absorption individually and together impact on bioavailability. This review defines the challenge presented by these drugs, outlines contemporary strategies to solve this challenge, and consequent in silico and in vitro evaluation of the delivery technologies for poorly water-soluble drugs. The next steps and unmet needs are proposed to present a roadmap for future studies for the field to consider enabling progress in delivery of poorly water-soluble compounds.

Original languageEnglish
Article number104967
JournalEuropean Journal of Pharmaceutical Sciences
Number of pages27
Publication statusPublished - 2019

    Research areas

  • Bioavailability, Drug delivery, Formulation, Lipid formulations, Poorly water-soluble drugs, Solid state

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