Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems. / Boyd, Ben J.; Bergström, Christel A.S.; Vinarov, Zahari; Kuentz, Martin; Brouwers, Joachim; Augustijns, Patrick; Brandl, Martin; Bernkop-Schnürch, Andreas; Shrestha, Neha; Préat, Véronique; Müllertz, Anette; Bauer-Brandl, Annette; Jannin, Vincent.

In: European Journal of Pharmaceutical Sciences, Vol. 137, 104967, 2019.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Boyd, BJ, Bergström, CAS, Vinarov, Z, Kuentz, M, Brouwers, J, Augustijns, P, Brandl, M, Bernkop-Schnürch, A, Shrestha, N, Préat, V, Müllertz, A, Bauer-Brandl, A & Jannin, V 2019, 'Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems', European Journal of Pharmaceutical Sciences, vol. 137, 104967. https://doi.org/10.1016/j.ejps.2019.104967

APA

Boyd, B. J., Bergström, C. A. S., Vinarov, Z., Kuentz, M., Brouwers, J., Augustijns, P., Brandl, M., Bernkop-Schnürch, A., Shrestha, N., Préat, V., Müllertz, A., Bauer-Brandl, A., & Jannin, V. (2019). Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems. European Journal of Pharmaceutical Sciences, 137, [104967]. https://doi.org/10.1016/j.ejps.2019.104967

Vancouver

Boyd BJ, Bergström CAS, Vinarov Z, Kuentz M, Brouwers J, Augustijns P et al. Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems. European Journal of Pharmaceutical Sciences. 2019;137. 104967. https://doi.org/10.1016/j.ejps.2019.104967

Author

Boyd, Ben J. ; Bergström, Christel A.S. ; Vinarov, Zahari ; Kuentz, Martin ; Brouwers, Joachim ; Augustijns, Patrick ; Brandl, Martin ; Bernkop-Schnürch, Andreas ; Shrestha, Neha ; Préat, Véronique ; Müllertz, Anette ; Bauer-Brandl, Annette ; Jannin, Vincent. / Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems. In: European Journal of Pharmaceutical Sciences. 2019 ; Vol. 137.

Bibtex

@article{c0e75840dc7d4cd68257642e8b282a99,
title = "Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems",
abstract = "Poorly water-soluble drugs continue to be a problematic, yet important class of pharmaceutical compounds for treatment of a wide range of diseases. Their prevalence in discovery is still high, and their development is usually limited by our lack of a complete understanding of how the complex chemical, physiological and biochemical processes that occur between administration and absorption individually and together impact on bioavailability. This review defines the challenge presented by these drugs, outlines contemporary strategies to solve this challenge, and consequent in silico and in vitro evaluation of the delivery technologies for poorly water-soluble drugs. The next steps and unmet needs are proposed to present a roadmap for future studies for the field to consider enabling progress in delivery of poorly water-soluble compounds.",
keywords = "Bioavailability, Drug delivery, Formulation, Lipid formulations, Poorly water-soluble drugs, Solid state",
author = "Boyd, {Ben J.} and Bergstr{\"o}m, {Christel A.S.} and Zahari Vinarov and Martin Kuentz and Joachim Brouwers and Patrick Augustijns and Martin Brandl and Andreas Bernkop-Schn{\"u}rch and Neha Shrestha and V{\'e}ronique Pr{\'e}at and Anette M{\"u}llertz and Annette Bauer-Brandl and Vincent Jannin",
year = "2019",
doi = "10.1016/j.ejps.2019.104967",
language = "English",
volume = "137",
journal = "Norvegica Pharmaceutica Acta",
issn = "0928-0987",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems

AU - Boyd, Ben J.

AU - Bergström, Christel A.S.

AU - Vinarov, Zahari

AU - Kuentz, Martin

AU - Brouwers, Joachim

AU - Augustijns, Patrick

AU - Brandl, Martin

AU - Bernkop-Schnürch, Andreas

AU - Shrestha, Neha

AU - Préat, Véronique

AU - Müllertz, Anette

AU - Bauer-Brandl, Annette

AU - Jannin, Vincent

PY - 2019

Y1 - 2019

N2 - Poorly water-soluble drugs continue to be a problematic, yet important class of pharmaceutical compounds for treatment of a wide range of diseases. Their prevalence in discovery is still high, and their development is usually limited by our lack of a complete understanding of how the complex chemical, physiological and biochemical processes that occur between administration and absorption individually and together impact on bioavailability. This review defines the challenge presented by these drugs, outlines contemporary strategies to solve this challenge, and consequent in silico and in vitro evaluation of the delivery technologies for poorly water-soluble drugs. The next steps and unmet needs are proposed to present a roadmap for future studies for the field to consider enabling progress in delivery of poorly water-soluble compounds.

AB - Poorly water-soluble drugs continue to be a problematic, yet important class of pharmaceutical compounds for treatment of a wide range of diseases. Their prevalence in discovery is still high, and their development is usually limited by our lack of a complete understanding of how the complex chemical, physiological and biochemical processes that occur between administration and absorption individually and together impact on bioavailability. This review defines the challenge presented by these drugs, outlines contemporary strategies to solve this challenge, and consequent in silico and in vitro evaluation of the delivery technologies for poorly water-soluble drugs. The next steps and unmet needs are proposed to present a roadmap for future studies for the field to consider enabling progress in delivery of poorly water-soluble compounds.

KW - Bioavailability

KW - Drug delivery

KW - Formulation

KW - Lipid formulations

KW - Poorly water-soluble drugs

KW - Solid state

U2 - 10.1016/j.ejps.2019.104967

DO - 10.1016/j.ejps.2019.104967

M3 - Journal article

C2 - 31252052

AN - SCOPUS:85068036241

VL - 137

JO - Norvegica Pharmaceutica Acta

JF - Norvegica Pharmaceutica Acta

SN - 0928-0987

M1 - 104967

ER -

ID: 241099573