SELECTIVE TRANSFORMATIONS OF THE CA-2+ PUMP INHIBITOR THAPSIGARGIN

Research output: Contribution to journalJournal article

The importance of the sesquiterpene lactone thapsigargin as a tool for studying Ca2+ homeostasis has created a need for structure-activity relationship studies and consequently for procedures for selective transformations of the functional groups in the molecule. Methods for the selective inversion of configuration at C-3 and C-8, selective acetylation, and selective cleavage of the ester groups at 0-3, 0-8 and 0-10 are presented.
Original languageUndefined/Unknown
JournalActa Chemica Scandinavica. Supplementum
Volume48
Issue number4
Pages (from-to)340-346
Number of pages7
ISSN0065-1133
Publication statusPublished - 1994

ID: 38061031