SELECTIVE TRANSFORMATIONS OF THE CA-2+ PUMP INHIBITOR THAPSIGARGIN
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SELECTIVE TRANSFORMATIONS OF THE CA-2+ PUMP INHIBITOR THAPSIGARGIN. / Andersen, A.; Cornett, Claus; Lauridsen, A.; Olsen, C. E.; Christensen, S. B.
In: Acta Chemica Scandinavica. Supplementum, Vol. 48, No. 4, 1994, p. 340-346.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - SELECTIVE TRANSFORMATIONS OF THE CA-2+ PUMP INHIBITOR THAPSIGARGIN
AU - Andersen, A.
AU - Cornett, Claus
AU - Lauridsen, A.
AU - Olsen, C. E.
AU - Christensen, S. B.
PY - 1994
Y1 - 1994
N2 - The importance of the sesquiterpene lactone thapsigargin as a tool for studying Ca2+ homeostasis has created a need for structure-activity relationship studies and consequently for procedures for selective transformations of the functional groups in the molecule. Methods for the selective inversion of configuration at C-3 and C-8, selective acetylation, and selective cleavage of the ester groups at 0-3, 0-8 and 0-10 are presented.
AB - The importance of the sesquiterpene lactone thapsigargin as a tool for studying Ca2+ homeostasis has created a need for structure-activity relationship studies and consequently for procedures for selective transformations of the functional groups in the molecule. Methods for the selective inversion of configuration at C-3 and C-8, selective acetylation, and selective cleavage of the ester groups at 0-3, 0-8 and 0-10 are presented.
KW - ca2+ transport atpases reticulum ca-2+-atpase thapsia-garganica tumor promoter high-affinity
M3 - Tidsskriftartikel
VL - 48
SP - 340
EP - 346
JO - Acta Chemica Scandinavica. Supplementum
JF - Acta Chemica Scandinavica. Supplementum
SN - 0065-1133
IS - 4
ER -
ID: 38061031