Raman spectroscopy in pharmaceutical product design

Research output: Contribution to journalJournal articleResearchpeer-review

Amrit Paudel, Dhara Raijada, Jukka Rantanen

Almost 100 years after the discovery of the Raman scattering phenomenon, related analytical techniques have emerged as important tools in biomedical sciences. Raman spectroscopy and microscopy are frontier, non-invasive analytical techniques amenable for diverse biomedical areas, ranging from molecular-based drug discovery, design of innovative drug delivery systems and quality control of finished products. This review presents concise accounts of various conventional and emerging Raman instrumentations including associated hyphenated tools of pharmaceutical interest. Moreover, relevant application cases of Raman spectroscopy in early and late phase pharmaceutical development, process analysis and micro-structural analysis of drug delivery systems are introduced. Finally, potential areas of future advancement and application of Raman spectroscopic techniques are discussed.

Original languageEnglish
JournalAdvanced Drug Delivery Reviews
Volume89
Pages (from-to)3-20
Number of pages18
ISSN0169-409X
DOIs
Publication statusPublished - 15 Jul 2015

    Research areas

  • Chemistry, Pharmaceutical, Drug Delivery Systems, Drug Design, Drug Discovery, Humans, Pharmaceutical Preparations, Quality Control, Spectrum Analysis, Raman, Technology, Pharmaceutical

ID: 161624362