Melt extrusion and spray drying of carbamazepine and dipyridamole with polyvinylpyrrolidone/vinyl acetate copolymers
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Melt extrusion and spray drying of carbamazepine and dipyridamole with polyvinylpyrrolidone/vinyl acetate copolymers. / Patterson, James E; James, Michael B; Forster, Angus H; Rades, Thomas.
In: Drug Development and Industrial Pharmacy, Vol. 34, No. 1, 2008, p. 95-106.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Melt extrusion and spray drying of carbamazepine and dipyridamole with polyvinylpyrrolidone/vinyl acetate copolymers
AU - Patterson, James E
AU - James, Michael B
AU - Forster, Angus H
AU - Rades, Thomas
PY - 2008
Y1 - 2008
N2 - Carbamazepine and dipyridamole are class II compounds (BCS) whose oral bioavailability is limited by poor solubility. The use of glass solutions to improve the bioavailability of this class of compound has been an area of research for a number of years. The influence of polymer parameters (Tg, hydrophilicity, solubility parameter, and ability to hydrogen bond) on glass solution properties is investigated.
AB - Carbamazepine and dipyridamole are class II compounds (BCS) whose oral bioavailability is limited by poor solubility. The use of glass solutions to improve the bioavailability of this class of compound has been an area of research for a number of years. The influence of polymer parameters (Tg, hydrophilicity, solubility parameter, and ability to hydrogen bond) on glass solution properties is investigated.
U2 - 10.1080/03639040701484627
DO - 10.1080/03639040701484627
M3 - Journal article
C2 - 18214761
VL - 34
SP - 95
EP - 106
JO - Drug Development and Industrial Pharmacy
JF - Drug Development and Industrial Pharmacy
SN - 0363-9045
IS - 1
ER -
ID: 40353767