Employees – University of Copenhagen

Innovative Methods and Applications in Mucoadhesion Research

Research output: Contribution to journalReviewResearchpeer-review

Alan R Mackie, Francisco M Goycoolea, Bianca Menchicchi, Carla Marcella Caramella, Francesca Saporito, Seunghwan Lee, Karen Stephansen, Ioannis S Chronakis, Marianne Hiorth, Malgorzata Adamczak, Max Waldner, Hanne Mørck Nielsen, Luciano Marcelloni

The present review is aimed at elucidating relatively new aspects of mucoadhesion/mucus interaction and related phenomena that emerged from a Mucoadhesion workshop held in Munster on 2-3 September 2015 as a satellite event of the ICCC 13th-EUCHIS 12th. After a brief outline of the new issues, the focus is on mucus description, purification, and mucus/mucin characterization, all steps that are pivotal to the understanding of mucus related phenomena and the choice of the correct mucosal model for in vitro and ex vivo experiments, alternative bio/mucomimetic materials are also presented. Then a selection of preparative techniques and testing methods are described (at molecular as well as micro and macroscale) that may support the pharmaceutical development of mucus interactive systems and assist formulators in the scale-up and industrialization steps. Recent applications of mucoadhesive systems (including medical devices) intended for different routes of administration (oral, gastrointestinal, vaginal, nasal, ocular, and intravesical) and for the treatment of difficult to treat pathologies or the alleviation of symptoms are described.

Original languageEnglish
Article number1600534
JournalMacromolecular Bioscience
Volume17
Issue number8
Number of pages32
ISSN1616-5187
DOIs
Publication statusPublished - Aug 2017

    Research areas

  • Journal Article, Review

ID: 185406676