Functionalized Food-Grade Biopolymer-Nanosilica Based Hybrid Hydrogels as Sustained Delivery Devices of Rutin

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  • Hriday Bera
  • Yasir Faraz Abbasi
  • Ang Kah Hoong
  • Low Phoe Be
  • Tay Juan Wuan
  • Haifei Guo
  • Dongmei Cun
  • Yang, Mingshi
  • Leong Yock Seen
  • Lim Lip Woan
  • Sia Qing Ying

Novel tamarind gum (TG) or carboxymethyl tamarind gum (CMTG) blended diethanolamine-functionalized pectin (DFP) based hydrogels reinforced with calcium silicate (CS) were developed for sustained delivery of rutin (RUT). The DFP (DA, 48.7%) and CMTG (DS, 50.0%) were initially synthesized and analyzed through 1H-NMR, FTIR, XRD and DSC studies. RUT-loaded hybrid hydrogels were subsequently afforded by Ca2+-induced gelation protocol. The hydrogels portrayed acceptable RUT entrapping efficiency (DEE, 29–43%), delayed eluting behaviour (Q6h, 65–100%) and variable swelling at 6 h (16–172%), which were significantly influenced by formulation variables. The RUT dissolution profile of the optimized hydrogels (F-5) obeyed Korsmeyer–Peppas kinetic model with anomalous transport driven mechanism. These matrices also demonstrated excellent mucoadhesion property and biodegradability. Furthermore, the hydrogels revealed their smooth but distorted surface morphology and drug-carrier compatibility with attenuated RUT crystallinity. These hydrogels matrices were thus evidenced to be appropriate for the delivery of hydrophobic RUT in its solubilised form.

Original languageEnglish
JournalJournal of Polymers and the Environment
Pages (from-to)260-270
Publication statusPublished - 2021

    Research areas

  • Biopolymer modification, Calcium silicate, High-methoxyl pectin, Nutraceuticals, Tamarind gum

ID: 250377150