Functionalized Food-Grade Biopolymer-Nanosilica Based Hybrid Hydrogels as Sustained Delivery Devices of Rutin
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Functionalized Food-Grade Biopolymer-Nanosilica Based Hybrid Hydrogels as Sustained Delivery Devices of Rutin. / Bera, Hriday; Abbasi, Yasir Faraz; Hoong, Ang Kah; Be, Low Phoe; Wuan, Tay Juan; Guo, Haifei; Cun, Dongmei; Yang, Mingshi; Seen, Leong Yock; Woan, Lim Lip; Ying, Sia Qing.
In: Journal of Polymers and the Environment, Vol. 29, 2021, p. 260-270.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Functionalized Food-Grade Biopolymer-Nanosilica Based Hybrid Hydrogels as Sustained Delivery Devices of Rutin
AU - Bera, Hriday
AU - Abbasi, Yasir Faraz
AU - Hoong, Ang Kah
AU - Be, Low Phoe
AU - Wuan, Tay Juan
AU - Guo, Haifei
AU - Cun, Dongmei
AU - Yang, Mingshi
AU - Seen, Leong Yock
AU - Woan, Lim Lip
AU - Ying, Sia Qing
PY - 2021
Y1 - 2021
N2 - Novel tamarind gum (TG) or carboxymethyl tamarind gum (CMTG) blended diethanolamine-functionalized pectin (DFP) based hydrogels reinforced with calcium silicate (CS) were developed for sustained delivery of rutin (RUT). The DFP (DA, 48.7%) and CMTG (DS, 50.0%) were initially synthesized and analyzed through 1H-NMR, FTIR, XRD and DSC studies. RUT-loaded hybrid hydrogels were subsequently afforded by Ca2+-induced gelation protocol. The hydrogels portrayed acceptable RUT entrapping efficiency (DEE, 29–43%), delayed eluting behaviour (Q6h, 65–100%) and variable swelling at 6 h (16–172%), which were significantly influenced by formulation variables. The RUT dissolution profile of the optimized hydrogels (F-5) obeyed Korsmeyer–Peppas kinetic model with anomalous transport driven mechanism. These matrices also demonstrated excellent mucoadhesion property and biodegradability. Furthermore, the hydrogels revealed their smooth but distorted surface morphology and drug-carrier compatibility with attenuated RUT crystallinity. These hydrogels matrices were thus evidenced to be appropriate for the delivery of hydrophobic RUT in its solubilised form.
AB - Novel tamarind gum (TG) or carboxymethyl tamarind gum (CMTG) blended diethanolamine-functionalized pectin (DFP) based hydrogels reinforced with calcium silicate (CS) were developed for sustained delivery of rutin (RUT). The DFP (DA, 48.7%) and CMTG (DS, 50.0%) were initially synthesized and analyzed through 1H-NMR, FTIR, XRD and DSC studies. RUT-loaded hybrid hydrogels were subsequently afforded by Ca2+-induced gelation protocol. The hydrogels portrayed acceptable RUT entrapping efficiency (DEE, 29–43%), delayed eluting behaviour (Q6h, 65–100%) and variable swelling at 6 h (16–172%), which were significantly influenced by formulation variables. The RUT dissolution profile of the optimized hydrogels (F-5) obeyed Korsmeyer–Peppas kinetic model with anomalous transport driven mechanism. These matrices also demonstrated excellent mucoadhesion property and biodegradability. Furthermore, the hydrogels revealed their smooth but distorted surface morphology and drug-carrier compatibility with attenuated RUT crystallinity. These hydrogels matrices were thus evidenced to be appropriate for the delivery of hydrophobic RUT in its solubilised form.
KW - Biopolymer modification
KW - Calcium silicate
KW - High-methoxyl pectin
KW - Nutraceuticals
KW - Tamarind gum
U2 - 10.1007/s10924-020-01876-8
DO - 10.1007/s10924-020-01876-8
M3 - Journal article
AN - SCOPUS:85090944850
VL - 29
SP - 260
EP - 270
JO - Journal of Polymers and the Environment
JF - Journal of Polymers and the Environment
SN - 1566-2543
ER -
ID: 250377150