Evaluating the effect of coating equipment on tablet film quality using terahertz pulsed imaging

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In this study, terahertz pulsed imaging (TPI) was employed to investigate the effect of the coating equipment (fluid bed and drum coater) on the structure of the applied film coating and subsequent dissolution behaviour. Six tablets from every batch coated with the same delayed release coating formulation under recommended process conditions (provided by the coating polymer supplier) were mapped individually to evaluate the effect of coating device on critical coating characteristics (coating thickness, surface morphology and density). Although the traditional coating quality parameter (weight gain) indicated no differences between both batches, TPI analysis revealed a lower mean coating thickness (CT) for tablets coated in the drum coater compared to fluid bed coated tablets (p
Original languageEnglish
JournalEuropean Journal of Pharmaceutics and Biopharmaceutics
Issue number3 Pt B
Pages (from-to)1095-102
Number of pages8
Publication statusPublished - Nov 2013

ID: 104835134