Evaluating the effect of coating equipment on tablet film quality using terahertz pulsed imaging

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Evaluating the effect of coating equipment on tablet film quality using terahertz pulsed imaging. / Haaser, Miriam; Naelapaa, Kaisa; Gordon, Keith C; Pepper, Michael; Rantanen, Jukka; Strachan, Clare J; Taday, Philip F; Zeitler, J Axel; Rades, Thomas.

In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 85, No. 3 Pt B, 11.2013, p. 1095-102.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Haaser, M, Naelapaa, K, Gordon, KC, Pepper, M, Rantanen, J, Strachan, CJ, Taday, PF, Zeitler, JA & Rades, T 2013, 'Evaluating the effect of coating equipment on tablet film quality using terahertz pulsed imaging', European Journal of Pharmaceutics and Biopharmaceutics, vol. 85, no. 3 Pt B, pp. 1095-102. https://doi.org/10.1016/j.ejpb.2013.03.019

APA

Haaser, M., Naelapaa, K., Gordon, K. C., Pepper, M., Rantanen, J., Strachan, C. J., Taday, P. F., Zeitler, J. A., & Rades, T. (2013). Evaluating the effect of coating equipment on tablet film quality using terahertz pulsed imaging. European Journal of Pharmaceutics and Biopharmaceutics, 85(3 Pt B), 1095-102. https://doi.org/10.1016/j.ejpb.2013.03.019

Vancouver

Haaser M, Naelapaa K, Gordon KC, Pepper M, Rantanen J, Strachan CJ et al. Evaluating the effect of coating equipment on tablet film quality using terahertz pulsed imaging. European Journal of Pharmaceutics and Biopharmaceutics. 2013 Nov;85(3 Pt B):1095-102. https://doi.org/10.1016/j.ejpb.2013.03.019

Author

Haaser, Miriam ; Naelapaa, Kaisa ; Gordon, Keith C ; Pepper, Michael ; Rantanen, Jukka ; Strachan, Clare J ; Taday, Philip F ; Zeitler, J Axel ; Rades, Thomas. / Evaluating the effect of coating equipment on tablet film quality using terahertz pulsed imaging. In: European Journal of Pharmaceutics and Biopharmaceutics. 2013 ; Vol. 85, No. 3 Pt B. pp. 1095-102.

Bibtex

@article{92e832d5ccee40f7ba18374de9503213,
title = "Evaluating the effect of coating equipment on tablet film quality using terahertz pulsed imaging",
abstract = "In this study, terahertz pulsed imaging (TPI) was employed to investigate the effect of the coating equipment (fluid bed and drum coater) on the structure of the applied film coating and subsequent dissolution behaviour. Six tablets from every batch coated with the same delayed release coating formulation under recommended process conditions (provided by the coating polymer supplier) were mapped individually to evaluate the effect of coating device on critical coating characteristics (coating thickness, surface morphology and density). Although the traditional coating quality parameter (weight gain) indicated no differences between both batches, TPI analysis revealed a lower mean coating thickness (CT) for tablets coated in the drum coater compared to fluid bed coated tablets (p",
author = "Miriam Haaser and Kaisa Naelapaa and Gordon, {Keith C} and Michael Pepper and Jukka Rantanen and Strachan, {Clare J} and Taday, {Philip F} and Zeitler, {J Axel} and Thomas Rades",
note = "Copyright {\textcopyright} 2013 Elsevier B.V. All rights reserved.",
year = "2013",
month = nov,
doi = "10.1016/j.ejpb.2013.03.019",
language = "English",
volume = "85",
pages = "1095--102",
journal = "European Journal of Pharmaceutics and Biopharmaceutics",
issn = "0939-6411",
publisher = "Elsevier",
number = "3 Pt B",

}

RIS

TY - JOUR

T1 - Evaluating the effect of coating equipment on tablet film quality using terahertz pulsed imaging

AU - Haaser, Miriam

AU - Naelapaa, Kaisa

AU - Gordon, Keith C

AU - Pepper, Michael

AU - Rantanen, Jukka

AU - Strachan, Clare J

AU - Taday, Philip F

AU - Zeitler, J Axel

AU - Rades, Thomas

N1 - Copyright © 2013 Elsevier B.V. All rights reserved.

PY - 2013/11

Y1 - 2013/11

N2 - In this study, terahertz pulsed imaging (TPI) was employed to investigate the effect of the coating equipment (fluid bed and drum coater) on the structure of the applied film coating and subsequent dissolution behaviour. Six tablets from every batch coated with the same delayed release coating formulation under recommended process conditions (provided by the coating polymer supplier) were mapped individually to evaluate the effect of coating device on critical coating characteristics (coating thickness, surface morphology and density). Although the traditional coating quality parameter (weight gain) indicated no differences between both batches, TPI analysis revealed a lower mean coating thickness (CT) for tablets coated in the drum coater compared to fluid bed coated tablets (p

AB - In this study, terahertz pulsed imaging (TPI) was employed to investigate the effect of the coating equipment (fluid bed and drum coater) on the structure of the applied film coating and subsequent dissolution behaviour. Six tablets from every batch coated with the same delayed release coating formulation under recommended process conditions (provided by the coating polymer supplier) were mapped individually to evaluate the effect of coating device on critical coating characteristics (coating thickness, surface morphology and density). Although the traditional coating quality parameter (weight gain) indicated no differences between both batches, TPI analysis revealed a lower mean coating thickness (CT) for tablets coated in the drum coater compared to fluid bed coated tablets (p

U2 - 10.1016/j.ejpb.2013.03.019

DO - 10.1016/j.ejpb.2013.03.019

M3 - Journal article

C2 - 23563103

VL - 85

SP - 1095

EP - 1102

JO - European Journal of Pharmaceutics and Biopharmaceutics

JF - European Journal of Pharmaceutics and Biopharmaceutics

SN - 0939-6411

IS - 3 Pt B

ER -

ID: 104835134