Effects of film coating thickness and drug layer uniformity on in vitro drug release from sustained-release coated pellets: a case study using terahertz pulsed imaging

Research output: Contribution to journalJournal articleResearchpeer-review

  • Louise Ho
  • Yvonne Cuppok
  • Susanne Muschert
  • Keith C Gordon
  • Michael Pepper
  • Yaochun Shen
  • Florence Siepmann
  • Juergen Siepmann
  • Philip F Taday
  • Rades, Thomas
Film coating thickness and terahertz electric field peak strength (TEFPS) were determined using terahertz pulsed imaging (TPI) and employed for the analysis of sustained-release coated pellets (theophylline layered sugar cores coated with Kollicoat SR:Kollicoat IR polymer blends). The effects of coating thickness, drug layer uniformity and optional curing were investigated using eight batches of pellets. Ten pellets from each batch were imaged with TPI to analyse the coating morphology (depicted in TEFPS) and thickness prior to release measurements. The results showed TEFPS values of 15.8% and 14.5% for pellets with a smooth drug layer coated at 8.2 and 12.5% (w/w) polymer weight-gain, respectively. Whereas 6.7% was derived for pellets with a coarse drug layer coated at both weight-gains. Although there were major differences in TEFPS, the resulting drug release kinetics were very similar. It was also shown that a 36 microm coating thickness difference was not drug release rate determining. These results suggested that drug release for the pellets studied was not predominately governed by drug diffusion through the polymeric film coating but probably to a large extent limited by drug solubility. TPI proved to be highly suitable to detect non-homogeneities in the drug layer and polymeric film coating.
Original languageEnglish
JournalInternational Journal of Pharmaceutics
Issue number1-2
Pages (from-to)151-9
Number of pages9
Publication statusPublished - 2009
Externally publishedYes

ID: 40348975