Effects of film coating thickness and drug layer uniformity on in vitro drug release from sustained-release coated pellets: a case study using terahertz pulsed imaging

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Effects of film coating thickness and drug layer uniformity on in vitro drug release from sustained-release coated pellets : a case study using terahertz pulsed imaging. / Ho, Louise; Cuppok, Yvonne; Muschert, Susanne; Gordon, Keith C; Pepper, Michael; Shen, Yaochun; Siepmann, Florence; Siepmann, Juergen; Taday, Philip F; Rades, Thomas.

In: International Journal of Pharmaceutics, Vol. 382, No. 1-2, 2009, p. 151-9.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Ho, L, Cuppok, Y, Muschert, S, Gordon, KC, Pepper, M, Shen, Y, Siepmann, F, Siepmann, J, Taday, PF & Rades, T 2009, 'Effects of film coating thickness and drug layer uniformity on in vitro drug release from sustained-release coated pellets: a case study using terahertz pulsed imaging', International Journal of Pharmaceutics, vol. 382, no. 1-2, pp. 151-9. https://doi.org/10.1016/j.ijpharm.2009.08.025

APA

Ho, L., Cuppok, Y., Muschert, S., Gordon, K. C., Pepper, M., Shen, Y., Siepmann, F., Siepmann, J., Taday, P. F., & Rades, T. (2009). Effects of film coating thickness and drug layer uniformity on in vitro drug release from sustained-release coated pellets: a case study using terahertz pulsed imaging. International Journal of Pharmaceutics, 382(1-2), 151-9. https://doi.org/10.1016/j.ijpharm.2009.08.025

Vancouver

Ho L, Cuppok Y, Muschert S, Gordon KC, Pepper M, Shen Y et al. Effects of film coating thickness and drug layer uniformity on in vitro drug release from sustained-release coated pellets: a case study using terahertz pulsed imaging. International Journal of Pharmaceutics. 2009;382(1-2):151-9. https://doi.org/10.1016/j.ijpharm.2009.08.025

Author

Ho, Louise ; Cuppok, Yvonne ; Muschert, Susanne ; Gordon, Keith C ; Pepper, Michael ; Shen, Yaochun ; Siepmann, Florence ; Siepmann, Juergen ; Taday, Philip F ; Rades, Thomas. / Effects of film coating thickness and drug layer uniformity on in vitro drug release from sustained-release coated pellets : a case study using terahertz pulsed imaging. In: International Journal of Pharmaceutics. 2009 ; Vol. 382, No. 1-2. pp. 151-9.

Bibtex

@article{06ccac0ff6c043d796fa28cd92597059,
title = "Effects of film coating thickness and drug layer uniformity on in vitro drug release from sustained-release coated pellets: a case study using terahertz pulsed imaging",
abstract = "Film coating thickness and terahertz electric field peak strength (TEFPS) were determined using terahertz pulsed imaging (TPI) and employed for the analysis of sustained-release coated pellets (theophylline layered sugar cores coated with Kollicoat SR:Kollicoat IR polymer blends). The effects of coating thickness, drug layer uniformity and optional curing were investigated using eight batches of pellets. Ten pellets from each batch were imaged with TPI to analyse the coating morphology (depicted in TEFPS) and thickness prior to release measurements. The results showed TEFPS values of 15.8% and 14.5% for pellets with a smooth drug layer coated at 8.2 and 12.5% (w/w) polymer weight-gain, respectively. Whereas 6.7% was derived for pellets with a coarse drug layer coated at both weight-gains. Although there were major differences in TEFPS, the resulting drug release kinetics were very similar. It was also shown that a 36 microm coating thickness difference was not drug release rate determining. These results suggested that drug release for the pellets studied was not predominately governed by drug diffusion through the polymeric film coating but probably to a large extent limited by drug solubility. TPI proved to be highly suitable to detect non-homogeneities in the drug layer and polymeric film coating.",
author = "Louise Ho and Yvonne Cuppok and Susanne Muschert and Gordon, {Keith C} and Michael Pepper and Yaochun Shen and Florence Siepmann and Juergen Siepmann and Taday, {Philip F} and Thomas Rades",
year = "2009",
doi = "10.1016/j.ijpharm.2009.08.025",
language = "English",
volume = "382",
pages = "151--9",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - Effects of film coating thickness and drug layer uniformity on in vitro drug release from sustained-release coated pellets

T2 - a case study using terahertz pulsed imaging

AU - Ho, Louise

AU - Cuppok, Yvonne

AU - Muschert, Susanne

AU - Gordon, Keith C

AU - Pepper, Michael

AU - Shen, Yaochun

AU - Siepmann, Florence

AU - Siepmann, Juergen

AU - Taday, Philip F

AU - Rades, Thomas

PY - 2009

Y1 - 2009

N2 - Film coating thickness and terahertz electric field peak strength (TEFPS) were determined using terahertz pulsed imaging (TPI) and employed for the analysis of sustained-release coated pellets (theophylline layered sugar cores coated with Kollicoat SR:Kollicoat IR polymer blends). The effects of coating thickness, drug layer uniformity and optional curing were investigated using eight batches of pellets. Ten pellets from each batch were imaged with TPI to analyse the coating morphology (depicted in TEFPS) and thickness prior to release measurements. The results showed TEFPS values of 15.8% and 14.5% for pellets with a smooth drug layer coated at 8.2 and 12.5% (w/w) polymer weight-gain, respectively. Whereas 6.7% was derived for pellets with a coarse drug layer coated at both weight-gains. Although there were major differences in TEFPS, the resulting drug release kinetics were very similar. It was also shown that a 36 microm coating thickness difference was not drug release rate determining. These results suggested that drug release for the pellets studied was not predominately governed by drug diffusion through the polymeric film coating but probably to a large extent limited by drug solubility. TPI proved to be highly suitable to detect non-homogeneities in the drug layer and polymeric film coating.

AB - Film coating thickness and terahertz electric field peak strength (TEFPS) were determined using terahertz pulsed imaging (TPI) and employed for the analysis of sustained-release coated pellets (theophylline layered sugar cores coated with Kollicoat SR:Kollicoat IR polymer blends). The effects of coating thickness, drug layer uniformity and optional curing were investigated using eight batches of pellets. Ten pellets from each batch were imaged with TPI to analyse the coating morphology (depicted in TEFPS) and thickness prior to release measurements. The results showed TEFPS values of 15.8% and 14.5% for pellets with a smooth drug layer coated at 8.2 and 12.5% (w/w) polymer weight-gain, respectively. Whereas 6.7% was derived for pellets with a coarse drug layer coated at both weight-gains. Although there were major differences in TEFPS, the resulting drug release kinetics were very similar. It was also shown that a 36 microm coating thickness difference was not drug release rate determining. These results suggested that drug release for the pellets studied was not predominately governed by drug diffusion through the polymeric film coating but probably to a large extent limited by drug solubility. TPI proved to be highly suitable to detect non-homogeneities in the drug layer and polymeric film coating.

U2 - 10.1016/j.ijpharm.2009.08.025

DO - 10.1016/j.ijpharm.2009.08.025

M3 - Journal article

C2 - 19716407

VL - 382

SP - 151

EP - 159

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1-2

ER -

ID: 40348975