Applications of terahertz pulsed imaging to sustained-release tablet film coating quality assessment and dissolution performance

Research output: Contribution to journalJournal articleResearchpeer-review

  • Louise Ho
  • Ronny Müller
  • Keith C Gordon
  • Peter Kleinebudde
  • Michael Pepper
  • Rades, Thomas
  • Yaochun Shen
  • Philip F Taday
  • J Axel Zeitler
The potential of terahertz pulsed imaging (TPI) to predict the dissolution performance in sustained-release tablets was investigated in this study. Batches of coated tablets with similar weight gain during the coating process at the lab and pilot scales were subjected to non-destructive imaging by TPI and subsequently analysed by dissolution testing. The results from the dissolution tests revealed significant differences in the product performance between the lab and pilot scales (Student t-test, P
Original languageEnglish
JournalJournal of controlled release : official journal of the Controlled Release Society
Issue number1
Pages (from-to)79-87
Number of pages9
Publication statusPublished - 2008
Externally publishedYes

ID: 40353590