Antiprotozoal properties of 16,17-dihydrobrachycalyxolide from Vernonia brachycalyx

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Extracts of the leaves from Vernonia brachycalyx showed in vitro activity against Plasmodium falciparum and promastigotes of Leishmania major. The germacrane dilactone 16,17-dihydrobrachycalyxolide (1) which was previously isolated from the aerial parts of the plant was shown to be the major antiplasmodial principle. An X-ray crystallographic analysis established the absolute configuration and some signals in the NMR spectra were reassigned. 16,17-Dihydrobrachycalyxolide (1) elicited a strong antiplasmodial and antileishmanial activity but also a high toxicity against human lymphocytes.
Original languageEnglish
JournalPlanta Medica
Issue number6
Pages (from-to)559-62
Number of pages3
Publication statusPublished - 1998

Bibliographical note

Keywords: Animals; Antiprotozoal Agents; Cell Survival; Humans; Leishmania major; Lymphocytes; Models, Molecular; Molecular Conformation; Molecular Structure; Plant Extracts; Plant Leaves; Plants, Medicinal; Sesquiterpenes, Germacrane

ID: 6765996