Antiprotozoal properties of 16,17-dihydrobrachycalyxolide from Vernonia brachycalyx
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Antiprotozoal properties of 16,17-dihydrobrachycalyxolide from Vernonia brachycalyx. / Oketch-Rabah, H A; Brøgger Christensen, S; Frydenvang, K; Dossaji, S F; Theander, T G; Cornett, C; Watkins, W M; Kharazmi, A; Lemmich, E.
In: Planta Medica, Vol. 64, No. 6, 1998, p. 559-62.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Antiprotozoal properties of 16,17-dihydrobrachycalyxolide from Vernonia brachycalyx
AU - Oketch-Rabah, H A
AU - Brøgger Christensen, S
AU - Frydenvang, K
AU - Dossaji, S F
AU - Theander, T G
AU - Cornett, C
AU - Watkins, W M
AU - Kharazmi, A
AU - Lemmich, E
N1 - Keywords: Animals; Antiprotozoal Agents; Cell Survival; Humans; Leishmania major; Lymphocytes; Models, Molecular; Molecular Conformation; Molecular Structure; Plant Extracts; Plant Leaves; Plants, Medicinal; Sesquiterpenes, Germacrane
PY - 1998
Y1 - 1998
N2 - Extracts of the leaves from Vernonia brachycalyx showed in vitro activity against Plasmodium falciparum and promastigotes of Leishmania major. The germacrane dilactone 16,17-dihydrobrachycalyxolide (1) which was previously isolated from the aerial parts of the plant was shown to be the major antiplasmodial principle. An X-ray crystallographic analysis established the absolute configuration and some signals in the NMR spectra were reassigned. 16,17-Dihydrobrachycalyxolide (1) elicited a strong antiplasmodial and antileishmanial activity but also a high toxicity against human lymphocytes.
AB - Extracts of the leaves from Vernonia brachycalyx showed in vitro activity against Plasmodium falciparum and promastigotes of Leishmania major. The germacrane dilactone 16,17-dihydrobrachycalyxolide (1) which was previously isolated from the aerial parts of the plant was shown to be the major antiplasmodial principle. An X-ray crystallographic analysis established the absolute configuration and some signals in the NMR spectra were reassigned. 16,17-Dihydrobrachycalyxolide (1) elicited a strong antiplasmodial and antileishmanial activity but also a high toxicity against human lymphocytes.
M3 - Journal article
C2 - 9741304
VL - 64
SP - 559
EP - 562
JO - Planta Medica
JF - Planta Medica
SN - 0032-0943
IS - 6
ER -
ID: 6765996