An oral delivery system for indomethicin engineered from cationic lipid emulsions and silica nanoparticles
Research output: Contribution to journal › Journal article › Research › peer-review
We report on a porous silica-lipid hybrid microcapsule (SLH) oral delivery system for indomethacin fabricated from Pickering emulsion templates, where the drug forms an electrostatic complex with cationic lipid present in the oil phase. Dry SLH microcapsules prepared either by spray drying (approximately 1-5 microm) or phase coacervation (20-50 microm) exhibit a specific internal porous matrix structure with pore diameters in the range of 20 to 100 nm. Dissolution studies under sink conditions and in the presence of electrolytes revealed a decreased extent of dissolution; this confirms the lipophilic nature the drug-lipid complex and its location in the oil phase. Orally dosed in-vivo studies in rats showed complete drug absorption and statistically higher fasted state bioavailability (F) (p
| Original language | English |
|---|---|
| Journal | Journal of controlled release : official journal of the Controlled Release Society |
| Volume | 143 |
| Issue number | 3 |
| Pages (from-to) | 367-73 |
| Number of pages | 7 |
| DOIs | |
| Publication status | Published - 2010 |
- Administration, Oral, Animals, Anti-Inflammatory Agents, Non-Steroidal, Cations, Drug Carriers, Emulsions, Indomethacin, Lipids, Male, Nanoparticles, Rats, Rats, Sprague-Dawley, Silicon Dioxide
Research areas
ID: 40348702