An oral delivery system for indomethicin engineered from cationic lipid emulsions and silica nanoparticles
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An oral delivery system for indomethicin engineered from cationic lipid emulsions and silica nanoparticles. / Simovic, Spomenka; Hui, He; Song, Yunmei; Davey, Andrew K; Rades, Thomas; Prestidge, Clive A.
In: Journal of controlled release : official journal of the Controlled Release Society, Vol. 143, No. 3, 2010, p. 367-73.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - An oral delivery system for indomethicin engineered from cationic lipid emulsions and silica nanoparticles
AU - Simovic, Spomenka
AU - Hui, He
AU - Song, Yunmei
AU - Davey, Andrew K
AU - Rades, Thomas
AU - Prestidge, Clive A
N1 - 2010. Published by Elsevier B.V. All rights reserved.
PY - 2010
Y1 - 2010
N2 - We report on a porous silica-lipid hybrid microcapsule (SLH) oral delivery system for indomethacin fabricated from Pickering emulsion templates, where the drug forms an electrostatic complex with cationic lipid present in the oil phase. Dry SLH microcapsules prepared either by spray drying (approximately 1-5 microm) or phase coacervation (20-50 microm) exhibit a specific internal porous matrix structure with pore diameters in the range of 20 to 100 nm. Dissolution studies under sink conditions and in the presence of electrolytes revealed a decreased extent of dissolution; this confirms the lipophilic nature the drug-lipid complex and its location in the oil phase. Orally dosed in-vivo studies in rats showed complete drug absorption and statistically higher fasted state bioavailability (F) (p
AB - We report on a porous silica-lipid hybrid microcapsule (SLH) oral delivery system for indomethacin fabricated from Pickering emulsion templates, where the drug forms an electrostatic complex with cationic lipid present in the oil phase. Dry SLH microcapsules prepared either by spray drying (approximately 1-5 microm) or phase coacervation (20-50 microm) exhibit a specific internal porous matrix structure with pore diameters in the range of 20 to 100 nm. Dissolution studies under sink conditions and in the presence of electrolytes revealed a decreased extent of dissolution; this confirms the lipophilic nature the drug-lipid complex and its location in the oil phase. Orally dosed in-vivo studies in rats showed complete drug absorption and statistically higher fasted state bioavailability (F) (p
KW - Administration, Oral
KW - Animals
KW - Anti-Inflammatory Agents, Non-Steroidal
KW - Cations
KW - Drug Carriers
KW - Emulsions
KW - Indomethacin
KW - Lipids
KW - Male
KW - Nanoparticles
KW - Rats
KW - Rats, Sprague-Dawley
KW - Silicon Dioxide
U2 - 10.1016/j.jconrel.2010.01.008
DO - 10.1016/j.jconrel.2010.01.008
M3 - Journal article
C2 - 20079390
VL - 143
SP - 367
EP - 373
JO - Journal of Controlled Release
JF - Journal of Controlled Release
SN - 0168-3659
IS - 3
ER -
ID: 40348702